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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CNN3, GGT7 (from a repository: Wed Jul 24 04:24:18 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins2 (12.50 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)25 (20.83 %)
The number (and %) of affected PPIs15 (60.00 %)
The number of possible different fusions2
PPI diameter5
PPI radius3
The average degree of PPI2.625
Assortativity coefficient-0.0645
The network average Clustering coefficient0.442
The number (and %) of a zero Clustering coefficients6 (37.50 %)
The number (and %) of a zero Betweenness Centrality9 (56.25 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GGT7,CNN3 All fusions
Proteins found in more fusions GGT7 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GGT7parental protein70.067118.000G_glu_transpept (PF01019, IPR000101): Gamma-glutamyltranspeptidase
2 CNN3parental protein80.179139.000Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
3 CARM1oncoprotein21.0000K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
CBP_GIL (PF10995, IPR017745): GGDEF I-site like or GIL domain
CARM1 (PF11531, IPR020989): Coactivator-associated arginine methyltransferase 1 N terminal
4 CNN2interactor21.0000Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
5 DCP2interactor21.0000DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
6 EMDinteractor40.6671.000LEM (PF03020, IPR003887, SM00540): LEM domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
7 FAM96Binteractor21.0000DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
8 GPR25interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
9 LHFPL5interactor100L_HMGIC_fpl (PF10242, IPR019372): Lipoma HMGIC fusion partner-like protein
10 MALLinteractor100MARVEL (PF01284, IPR008253): Membrane-associating domain
PsbM (PF05151, IPR007826): Photosystem II reaction centre M protein (PsbM)
11 MTHFD1Linteractor21.0000FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase
THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
12 NTRK1oncoprotein50.5003.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
13 PAN2interactor30.6671.000RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
14 TMEM242interactor20108.000DUF1358 (PF07096, IPR009792): Protein of unknown function (DUF1358)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
15 VKORC1interactor30112.000VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family
16 YKT6interactor100Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain

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