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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ITGB2, LRRC75A-AS1 (from a repository: Sat Aug 25 07:16:37 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)31
The number (and %) of the onco-proteins8 (25.81 %)
The number (and %) of the tumor suppressors7 (22.58 %)
Total number of binary PPIs (saturation %)80 (17.20 %)
The number (and %) of affected PPIs29 (36.25 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI4.129
Assortativity coefficient-0.3769
The network average Clustering coefficient0.405
The number (and %) of a zero Clustering coefficients9 (29.03 %)
The number (and %) of a zero Betweenness Centrality13 (41.94 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LRRC75A-AS1,ITGB2 All fusions
Proteins found in more fusions RANBP9 (see 2 fusions); PRKCE (see 3 fusions); COPS5 (see 1 fusions); PRKCD (see 2 fusions); YWHAZ (see 1 fusions); SYK (see 1 fusions); EGFR (see 2 fusions); RACK1 (see 3 fusions); RBPMS (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LRRC75A-AS1parental protein30114.000NA
2 ITGB2parental protein260.086618.246EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin beta chain VWA domain
PSI_integrin (PF17205): Integrin plexin domain
3 C3interactor100A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
ANATO (PF01821, IPR000020, SM00104): Anaphylotoxin-like domain
NTR (PF01759, IPR018933, SM00206): UNC-6/NTR/C345C module
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
4 CD226interactor100DUF1443 (PF07280, IPR009903): Protein of unknown function (DUF1443)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
5 COPS5protein found in more fusions60.40023.300JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
6 CYTH1interactor100DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
PH (PF00169, IPR001849, SM00233): PH domain
Sec7 (PF01369, IPR000904, SM00222): Sec7 domain
7 EGFRoncoprotein110.28935.715Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
8 ELAVL1oncoprotein90.107175.233RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
9 FHL2oncoprotein200LIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
10 ICAM1oncoprotein30.6671.000Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
11 ITGADinteractor21.0000FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
12 ITGALinteractor30.6671.000FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
13 KLF10suppressor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
AAA_33 (PF13671): AAA domain
14 KNG1interactor21.0000Bradykinin (PF06753, IPR009608): Bradykinin
Chorion_2 (PF03964, IPR005649): Chorion family 2
Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
15 NOTCH2NLinteractor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
16 PLAURoncoprotein30.33322.645Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
17 PRKCAinteractor60.50022.239C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
18 PRKCBsuppressor50.5001.667C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
19 PRKCDsuppressor70.26738.528Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
20 PRKCEsuppressor60.50022.239C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
21 PRKCGinteractor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
22 PSMD4interactor21.0000UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
23 PTK2Binteractor50.6672.227FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
24 RACK1suppressor70.46722.378WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
25 RANBP9suppressor50.5004.278Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
LisH (PF08513, IPR013720, SM00667): LisH
SPRY (PF00622, IPR003877, SM00449): SPRY domain
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
26 RBPMSprotein found in more fusions200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
27 SHARPINinteractor40.6671.000DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Sharpin_PH (PF16764, IPR031912): Sharpin PH domain
28 SYKsuppressor41.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
29 VNN2interactor100CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
30 YWHABinteractor40.50021.23914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
31 YWHAZprotein found in more fusions80.4297.06714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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