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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)122
The number (and %) of the onco-proteins41 (33.61 %)
The number (and %) of the tumor suppressors28 (22.95 %)
Total number of binary PPIs (saturation %)879 (11.91 %)
The number (and %) of affected PPIs121 (13.77 %)
The number of possible different fusions33
PPI diameter2
PPI radiusinf
The average degree of PPI13.443
Assortativity coefficient-0.2536
The network average Clustering coefficient0.536
The number (and %) of a zero Clustering coefficients5 (4.10 %)
The number (and %) of a zero Betweenness Centrality15 (12.30 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: YY1,SLC25A29 All fusions
Proteins found in more fusions APP (see 5 fusions); SMAD4 (see 3 fusions); RUVBL1 (see 1 fusions); SMAD2 (see 2 fusions); NPM1 (see 1 fusions); BCL6 (see 2 fusions); HDAC4 (see 1 fusions); NFKB1 (see 2 fusions); CREB1 (see 1 fusions); YY1 (see 1 fusions); MYC (see 2 fusions); SP1 (see 1 fusions); SREBF1 (see 1 fusions); CREBBP (see 6 fusions); NEDD4L (see 4 fusions); KAT2B (see 1 fusions); PRKDC (see 2 fusions); SMURF2 (see 1 fusions); TCF3 (see 4 fusions); HDAC5 (see 1 fusions); EZH2 (see 1 fusions); EP300 (see 1 fusions); HCFC1 (see 2 fusions); DDX5 (see 1 fusions); APP/GABPA (see 1 fusions); RING1 (see 1 fusions); PCGF2 (see 1 fusions); NEDD4 (see 1 fusions); NCL (see 4 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 YY1parental protein1210.0988527.308zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
2 SLC25A29interactor000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
3 ACTL6Ainteractor210.52470.170Actin (PF00022, IPR004000, SM00268): Actin
4 ACTR5interactor141.0000Actin (PF00022, IPR004000, SM00268): Actin
DUF1542 (PF07564, IPR011439): Domain of Unknown Function (DUF1542)
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
5 ACTR8interactor151.0000Actin (PF00022, IPR004000, SM00268): Actin
6 APPprotein found in more fusions210.23293.157APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
7 ARRB1interactor80.5006.174Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
8 ATF2oncoprotein120.49110.186bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
9 ATF6interactor50.5001.202bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
10 ATF7interactor30.6670.250bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
11 BAP1suppressor40.6672.000Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
12 BAXsuppressor70.8000.767Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
13 BCL6oncoprotein140.38526.306BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
14 BMI1oncoprotein220.34868.536zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
15 CDKN2Asuppressor110.7093.279Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
16 CEP164interactor30.6670.333DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
WW (PF00397, IPR001202, SM00456): WW domain
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
17 CREB1oncoprotein150.35238.690bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
18 CREBBPsuppressor280.37092.930Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
19 CRKLoncoprotein30.6670.667SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
20 CTCFsuppressor70.5712.716cwf18 (PF08315, IPR013169): cwf18 pre-mRNA splicing factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
21 DDX3Xsuppressor140.37419.118DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
22 DDX5oncoprotein170.56714.409DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
P68HR (PF08061, IPR012587): P68HR (NUC004) repeat
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
23 DNMT3Linteractor130.44922.187CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
24 EEDsuppressor290.331117.359WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
25 ELAVL1oncoprotein380.173398.419RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26 EP300oncoprotein410.267293.672Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
27 EZH2suppressor160.45724.162CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
28 FKBP1Ainteractor40.6670.286FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
29 FKBP3interactor80.5715.862FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
30 FOXB1interactor40.6670.571Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
31 FOXJ2interactor70.5247.071SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
32 FOXL1oncoprotein31.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
33 FOXN1interactor40.6671.067Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
34 GABPAprotein found in more fusions90.47213.286Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
GABP-alpha (PF11620, IPR024668): GA-binding protein alpha chain
Wap1 (PF16997, IPR031550): Wap1 domain
35 GABPB1oncoprotein40.5002.333Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_23 (PF13476): AAA domain
Ank_4 (PF13637): Ankyrin repeats (many copies)
DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
36 GRNoncoprotein40.5001.867Granulin (PF00396, IPR000118, SM00277): Granulin
Lustrin_cystein (PF14625, IPR028150): Lustrin, cysteine-rich repeated domain
37 HCFC1protein found in more fusions130.40920.783fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
38 HDAC1suppressor430.259333.610FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
39 HDAC2suppressor360.245246.067Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
40 HDAC3suppressor180.38234.231Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
41 HDAC4oncoprotein120.38216.953Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
42 HDAC5protein found in more fusions230.30771.983Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
43 HOXA11oncoprotein31.0000DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF3528 (PF12045, IPR021918): Protein of unknown function (DUF3528)
44 HSPA4interactor220.30771.875Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
45 HSPA5oncoprotein150.45122.078HSP70 (PF00012, IPR013126): Hsp70 protein
46 ILF3oncoprotein160.45829.680dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
47 INO80interactor150.8868.000Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
POTRA (PF07244, IPR010827): Surface antigen variable number repeat
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DBINO (PF13892, IPR020838): DNA-binding domain
FAM176 (PF14851): FAM176 family
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
48 INO80Binteractor141.0000PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region
zf-HIT (PF04438, IPR007529): HIT zinc finger
DUF3619 (PF12279, IPR022064): Protein of unknown function (DUF3619)
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
49 INO80Cinteractor150.8866.675YL1_C (PF08265, IPR013272, SM00993): YL1 nuclear protein C-terminal domain
50 INO80Dinteractor141.0000WRC (PF08879, IPR014977): WRC
zf-C3Hc3H (PF13891, IPR025927): Potential DNA-binding domain
51 INO80Einteractor150.87611.333NBP1 (PF08537, IPR013743): Fungal Nap binding protein NBP1
52 JUNBoncoprotein80.6433.144bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
53 JUNDoncoprotein70.4762.703bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
54 KAT2Bprotein found in more fusions160.57113.934Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
55 KMT2Einteractor50.8000.393CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
SET (PF00856, IPR001214, SM00317): SET domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx
DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
56 LAMC2interactor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_II (PF06009, IPR010307): Laminin Domain II
Rho_Binding (PF08912, IPR015008): Rho Binding
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
hEGF (PF12661, IPR013032): Human growth factor-like EGF
57 MAXsuppressor110.44410.493ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
58 MCRS1interactor150.8868.000FHA (PF00498, IPR000253, SM00240): FHA domain
MCRS_N (PF13325, IPR025999): N-terminal region of micro-spherule protein
59 MDM2oncoprotein270.36090.902Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
60 MECP2interactor90.4448.862K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
61 MTA2interactor110.5459.784BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain
DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
62 MYConcoprotein280.36294.828HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
63 NCLprotein found in more fusions210.44240.073DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
64 NEDD4suppressor130.30331.282Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
65 NEDD4Lsuppressor80.4295.456WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
66 NFE2L2oncoprotein60.8670.321bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
67 NFKB1suppressor160.41027.920Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
68 NFRKBinteractor150.87611.333ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
PSRT (PF07636, IPR011504): PSRT
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
NFRKB_winged (PF14465, IPR025220): NFRKB Winged Helix-like
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
69 NOTCH1suppressor160.39028.355Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
70 NPM1suppressor210.37457.290Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
71 NR1H2oncoprotein30.6670.400zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
72 PCGF2suppressor80.8101.317zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
73 PPIAinteractor50.4001.627Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
74 PPP1R3Binteractor100CBM_21 (PF03370, IPR005036): Carbohydrate/starch-binding module (family 21)
75 PRKDCprotein found in more fusions200.43930.881FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
76 PRMT1interactor100.5564.695Methyltransf_25 (PF13649): Methyltransferase domain
77 PSMD9interactor40.6672.000Remorin_C (PF03763, IPR005516): Remorin, C-terminal region
DUF2046 (PF09755, IPR019152): Uncharacterized conserved protein H4 (DUF2046)
PDZ_2 (PF13180, IPR001478): PDZ domain
78 RAF1oncoprotein90.3219.447Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
79 RB1suppressor200.37957.272RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
80 RELBoncoprotein50.5002.467RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
RelB_leu_zip (PF16180, IPR032399): RelB leucine zipper
RelB_transactiv (PF16181, IPR032400): RelB transactivation domain
81 RING1protein found in more fusions160.41028.456zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
82 RNF2interactor310.297157.552zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
83 RUVBL1oncoprotein250.43893.226TIP49 (PF06068, IPR010339): TIP49 C-terminus
84 RUVBL2oncoprotein320.348190.594TIP49 (PF06068, IPR010339): TIP49 C-terminus
85 RYBPinteractor100.6448.850DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
86 SAP30interactor50.7000.821Titin_Z (PF09042, IPR015129): Titin Z
zf-SAP30 (PF13866, IPR025717): SAP30 zinc-finger
SAP30_Sin3_bdg (PF13867, IPR025718): Sin3 binding region of histone deacetylase complex subunit SAP30
87 SHFM1interactor30.6671.000CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
88 SKP2suppressor100.48913.484LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_2 (PF07723, IPR013101): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
89 SLC39A7interactor30.6670.182Zip (PF02535, IPR003689): ZIP Zinc transporter
90 SMAD1interactor130.6368.979MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
91 SMAD2suppressor190.50332.440MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
92 SMAD3oncoprotein300.310146.537MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
93 SMAD4suppressor170.49228.476MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
94 SMARCAD1interactor160.29240.667CUE (PF02845, IPR003892, SM00546): CUE domain
Pox_D5 (PF03288, IPR004968): Poxvirus D5 protein-like
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
95 SMURF2protein found in more fusions70.9330.400C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
96 SNU13interactor80.5714.538Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
97 SP1protein found in more fusions290.339119.626zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
98 SP3interactor90.7502.989K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
99 SPRY1interactor40.5002.400PAP1 (PF08601, IPR013910): Transcription factor PAP1
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
100 SREBF1protein found in more fusions60.8000.450HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
101 SUZ12suppressor210.38459.753DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
102 TCF3suppressor110.53310.141CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
103 TERF1interactor100.5284.808TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
104 TERF2interactor150.36329.042Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
105 TESK1interactor21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
106 TFAP2Asuppressor140.46219.760TF_AP-2 (PF03299, IPR013854): Transcription factor AP-2
CYYR1 (PF10873, IPR022640): Cysteine and tyrosine-rich protein 1
Peptidase_Prp (PF04327): Cysteine protease Prp
107 TFCP2interactor50.7001.833CP2 (PF04516, IPR007604): CP2 transcription factor
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
108 TFPToncoprotein160.8955.186GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
109 TMEM150Ainteractor100Frag1 (PF10277, IPR019402): Frag1/DRAM/Sfk1 family
110 TP53suppressor450.247399.368DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
111 TRPV5interactor21.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ion_trans (PF00520, IPR005821): Ion transport protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
112 TWIST1oncoprotein100.5338.518ACC_epsilon (PF13822, IPR032716): Acyl-CoA carboxylase epsilon subunit
PRR20 (PF15708, IPR031439): Proline-rich protein family 20
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
113 UCHL5oncoprotein200.59152.445Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
114 UHRF2suppressor90.5715.330PHD (PF00628, IPR019787, SM00249): PHD-finger
SAD_SRA (PF02182, IPR003105, SM00466): SAD/SRA domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
TTD (PF12148, IPR021991): Tandem tudor domain within UHRF1
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
115 WDHD1interactor21.0000PVL_ORF50 (PF07768, IPR011688): PVL ORF-50-like family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
Mcl1_mid (PF12341, IPR022100): Minichromosome loss protein, Mcl1, middle region
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
116 XRCC5suppressor190.35941.992Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
117 XRCC6oncoprotein230.39059.865Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain
118 YAF2interactor70.5714.825DUF460 (PF04312, IPR007408): Protein of unknown function (DUF460)
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Exo5 (PF09810, IPR019190): Exonuclease V - a 5' deoxyribonuclease
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
YAF2_RYBP (PF17219): Yaf2/RYBP C-terminal binding motif
119 ZNF232interactor100SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
120 ZNF24interactor30.6670.182SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
121 ZNF638interactor60.8670.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-met (PF12874): Zinc-finger of C2H2 type
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
122 ZNF830interactor21.0000Sec34 (PF04136, IPR007265): Sec34-like family
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding

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