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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PTPRF, ANO4 (from a repository: Fri Jul 26 19:07:22 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)40
The number (and %) of the onco-proteins13 (32.50 %)
The number (and %) of the tumor suppressors4 (10.00 %)
Total number of binary PPIs (saturation %)114 (14.62 %)
The number (and %) of affected PPIs38 (33.33 %)
The number of possible different fusions9
PPI diameter2
PPI radiusinf
The average degree of PPI4.900
Assortativity coefficient-0.2755
The network average Clustering coefficient0.523
The number (and %) of a zero Clustering coefficients9 (22.50 %)
The number (and %) of a zero Betweenness Centrality17 (42.50 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ANO4,PTPRF All fusions
Proteins found in more fusions PRPF40A (see 2 fusions); CUL7 (see 2 fusions); PTPRF/EGFR (see 1 fusions); PFKM (see 1 fusions); MAPK1 (see 2 fusions); EGFR (see 2 fusions); NID1 (see 1 fusions); PPFIA1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ANO4interactor000Anoctamin (PF04547, IPR007632): Calcium-activated chloride channel
Anoct_dimer (PF16178, IPR032394): Dimerisation domain of Ca+-activated chloride-channel, anoctamin
2 PTPRFparental protein380.0851094.467Arylsulfotrans (PF05935, IPR010262): Arylsulfotransferase (ASST)
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377)
3 ABCE1interactor50.8330.500ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
4 ARPC3interactor21.0000P21-Arc (PF04062, IPR007204): ARP2/3 complex ARPC3 (21 kDa) subunit
5 CAV1suppressor70.4768.233Caveolin (PF01146, IPR001612): Caveolin
6 CDKN2AIPinteractor100XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
7 CEACAM21interactor21.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
8 CTNNB1oncoprotein80.42914.167Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
9 CUL7protein found in more fusions60.4004.833ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
10 DNAAF5interactor70.4767.233HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
11 EGFRoncoprotein100.50010.400Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
12 GIT1interactor70.6004.733ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
FlxA (PF14282, IPR025577): FlxA-like protein
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
13 GRK2interactor50.4003.733ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
14 HACL1interactor200TPP_enzyme_C (PF02775, IPR011766): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
TPP_enzyme_N (PF02776, IPR012001): Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
15 HEPACAM2interactor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
PgaD (PF13994, IPR023829): PgaD-like protein
16 JUPsuppressor60.6004.500Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
17 MAPK1oncoprotein100.36117.067Pkinase (PF00069, IPR000719): Protein kinase domain
18 NAA50interactor100Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
19 NID1protein found in more fusions31.0000EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
G2F (PF07474, IPR006605, SM00682): G2F domain
NIDO (PF06119, IPR003886, SM00539): Nidogen-like
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
20 NPLOC4interactor50.6003.167NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
21 NTRK1oncoprotein190.24897.900I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
22 PFKMprotein found in more fusions60.8001.000PFK (PF00365, IPR000023): Phosphofructokinase
23 PICALMoncoprotein60.6004.500ANTH (PF07651, IPR011417): ANTH domain
24 PPFIA1protein found in more fusions70.6674.000HWE_HK (PF07536, IPR011102, SM00911): HWE histidine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Cluap1 (PF10234, IPR019366): Clusterin-associated protein-1
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
TSNAXIP1_N (PF15739, IPR032755): Translin-associated factor X-interacting N-terminus
FAM76 (PF16046, IPR032017): FAM76 protein
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
25 PPFIA2interactor51.0000DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
HWE_HK (PF07536, IPR011102, SM00911): HWE histidine kinase
IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SlyX (PF04102, IPR007236): SlyX
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
26 PPFIA3interactor51.0000DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
T2SSF (PF00482, IPR018076): Type II secretion system (T2SS), protein F
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
Tup_N (PF08581, IPR013890): Tup N-terminal
FTA4 (PF13093, IPR025207): Kinetochore complex Fta4 of Sim4 subunit, or CENP-50
FAM76 (PF16046, IPR032017): FAM76 protein
27 PPP2R5Dinteractor40.8330.667B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
28 PPWD1interactor30.6670.400DUF505 (PF04458, IPR007548): Protein of unknown function (DUF505)
Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
29 PRPF40Aprotein found in more fusions40.6670.500FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
30 REToncoprotein50.8330.333Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
31 RYKoncoprotein40.5002.500Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain
32 SCN2Binteractor100DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
33 SEPHS1interactor200AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
34 SKILsuppressor31.0000c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
35 TGFBR2suppressor21.0000ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
36 TRIOoncoprotein21.0000T3SS_needle_E (PF08988, IPR012671): Type III secretion system, cytoplasmic E component of needle
GRP (PF07172, IPR010800): Glycine rich protein family
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pap_E4 (PF02711, IPR003861): E4 protein
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Spectrin (PF00435, IPR002017): Spectrin repeat
CRAL_TRIO (PF00650, IPR001251, SM00516): CRAL/TRIO domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Myb_DNA-bind_4 (PF13837): Myb/SANT-like DNA-binding domain
PH_10 (PF15411): Pleckstrin homology domain
SH3-RhoG_link (PF16609): SH3-RhoGEF linking unstructured region
37 TSTA3interactor100Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
NICE-3 (PF07406, IPR010876): NICE-3 protein
Polysacc_synt_2 (PF02719, IPR003869): Polysaccharide biosynthesis protein
38 UFD1Linteractor30.6670.667UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
39 UNKinteractor30.6670.500MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
40 ZNF512Binteractor100YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

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