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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)145
The number (and %) of the onco-proteins58 (40.00 %)
The number (and %) of the tumor suppressors33 (22.76 %)
Total number of binary PPIs (saturation %)823 (7.88 %)
The number (and %) of affected PPIs145 (17.62 %)
The number of possible different fusions32
PPI diameter4
PPI radius2
The average degree of PPI10.455
Assortativity coefficient-0.2751
The network average Clustering coefficient0.438
The number (and %) of a zero Clustering coefficients25 (17.24 %)
The number (and %) of a zero Betweenness Centrality27 (18.62 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HDAC4,SERPINA3 All fusions
Proteins found in more fusions CTBP1 (see 2 fusions); PPARD (see 1 fusions); APP (see 4 fusions); SYK (see 1 fusions); YWHAG (see 1 fusions); LZTR1 (see 2 fusions); MAPK1 (see 1 fusions); NUP214 (see 1 fusions); GSK3B (see 1 fusions); HDAC7 (see 1 fusions); CUL7 (see 2 fusions); BCL6 (see 2 fusions); ATXN1 (see 3 fusions); HDAC4 (see 1 fusions); NFKB1 (see 2 fusions); YY1 (see 2 fusions); YWHAH (see 2 fusions); SP1 (see 1 fusions); IKZF1 (see 1 fusions); SF1 (see 1 fusions); RARA (see 4 fusions); YWHAZ (see 1 fusions); MARK3 (see 1 fusions); CAMK2D (see 1 fusions); RXRA (see 2 fusions); HDAC5 (see 1 fusions); ZBTB16 (see 3 fusions); SUV39H1 (see 1 fusions); SENP1 (see 1 fusions); STAT1 (see 1 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HDAC4parental protein1300.07212251.210Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
2 SERPINA3parental protein1501575.744Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
3 ABCC5interactor100ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
4 ACTA1interactor30.6670.333Actin (PF00022, IPR004000, SM00268): Actin
5 ADH1Binteractor2026.429ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
6 AHRRsuppressor40.8330.400HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
7 ANKRA2interactor90.41719.575Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
8 APPprotein found in more fusions290.151812.429APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
9 ARoncoprotein220.37165.916Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
10 ATF2oncoprotein150.33045.212bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
11 ATF3suppressor130.45525.176bZIP_1 (PF00170, IPR004827): bZIP transcription factor
12 ATP6V1B1interactor3051.513ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
13 ATRXoncoprotein100DDHD (PF02862, IPR004177, SM01127): DDHD domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Pap_E4 (PF02711, IPR003861): E4 protein
PHD (PF00628, IPR019787, SM00249): PHD-finger
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Zip (PF02535, IPR003689): ZIP Zinc transporter
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
FAM176 (PF14851): FAM176 family
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
14 ATXN1protein found in more fusions90.39320.319AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
15 BCL6oncoprotein150.42922.305BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
16 BCORoncoprotein90.7142.756Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region
PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
17 BCORL1suppressor40.8330.200Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region
PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
18 BRMS1suppressor90.53615.361Dynactin_p62 (PF05502, IPR008603): Dynactin p62 family
Sds3 (PF08598, IPR013907): Sds3-like
19 C16orf70interactor3069.581UPF0183 (PF03676, IPR005373): Uncharacterised protein family (UPF0183)
20 CACNA1Cinteractor21.0000Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
Ion_trans (PF00520, IPR005821): Ion transport protein
Rer1 (PF03248, IPR004932): Rer1 family
ODV-E18 (PF10717, IPR019655): Occlusion-derived virus envelope protein ODV-E18
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
CAC1F_C (PF16885, IPR031688): Voltage-gated calcium channel subunit alpha, C-term
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
21 CAMK1interactor60.4677.673Pkinase (PF00069, IPR000719): Protein kinase domain
Tyrosinase (PF00264, IPR002227): Common central domain of tyrosinase
22 CAMK2Doncoprotein31.0000CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain
Pkinase (PF00069, IPR000719): Protein kinase domain
23 CAMK4interactor100DUF1103 (PF06513, IPR009484): Repeat of unknown function (DUF1103)
Pkinase (PF00069, IPR000719): Protein kinase domain
24 CCDC136suppressor21.0000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
Com_YlbF (PF06133, IPR010368): Control of competence regulator ComK, YlbF/YmcA
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Sec34 (PF04136, IPR007265): Sec34-like family
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
FlxA (PF14282, IPR025577): FlxA-like protein
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
25 CDK5oncoprotein60.7001.471Pkinase (PF00069, IPR000719): Protein kinase domain
26 CDKN1Asuppressor150.276123.917CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
27 CDR2interactor200DivIC (PF04977, IPR007060): Septum formation initiator
SlyX (PF04102, IPR007236): SlyX
Striatin (PF08232, IPR013258): Striatin family
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
28 CEBPDsuppressor40.5000.573bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
29 CIITAoncoprotein80.4649.202NACHT (PF05729): NACHT domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
30 CSRP3interactor100LIM (PF00412, IPR001781, SM00132): LIM domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
31 CTBP1protein found in more fusions200.31077.3082-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
32 CTNNB1oncoprotein250.263168.867Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
33 CUL7protein found in more fusions200.281180.056ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
34 DDX19Binteractor3049.218DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
35 DNAJB5interactor100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
36 DNAJB6interactor31.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
37 DNAJB8interactor100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
38 DNAJC1interactor100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF4234 (PF14018, IPR025328): Domain of unknown function (DUF4234)
39 EFEMP2interactor21.0000EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Adipogenin (PF15202, IPR027938): Adipogenin
40 ELANEinteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
41 ELAVL1oncoprotein220.186196.588RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
42 ESCO2interactor21.0000Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
zf-C2H2_3 (PF13878, IPR028005): zinc-finger of acetyl-transferase ESCO
Acetyltransf_13 (PF13880, IPR028009): ESCO1/2 acetyl-transferase
43 ESR1suppressor320.286211.693Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
44 FOXP3suppressor90.30615.210Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
45 GATA1oncoprotein60.7331.129GATA (PF00320, IPR000679, SM00401): GATA zinc finger
Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain
46 GATA3oncoprotein60.40036.785GATA (PF00320, IPR000679, SM00401): GATA zinc finger
Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain
47 GCM1interactor60.5334.797DUF1272 (PF06906, IPR010696): Protein of unknown function (DUF1272)
GCM (PF03615, IPR003902): GCM motif protein
48 GDPD1interactor100GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
49 GNB1interactor50.40096.691Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
50 GOLGA2interactor50.8001.533ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
51 GSK3Bsuppressor120.43627.301Pkinase (PF00069, IPR000719): Protein kinase domain
52 HDAC3suppressor460.194588.846Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
53 HDAC5protein found in more fusions590.1551194.999Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
54 HDAC7protein found in more fusions320.305198.354Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
55 HDAC9interactor190.22973.520Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
CEP19 (PF14933, IPR029412): CEP19-like protein
56 HIC1suppressor80.6193.007BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
57 HIF1Asuppressor120.6068.302Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
58 HNF4Asuppressor130.51513.042zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
59 IFRD1interactor40.6670.333IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
IFRD_C (PF04836, IPR006921): Interferon-related protein conserved region
60 IKZF1suppressor140.57713.801Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
61 IKZF2suppressor70.8670.556ADK_lid (PF05191, IPR007862): Adenylate kinase, active site lid
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
62 IKZF3suppressor120.49119.094C1_2 (PF03107, IPR004146): C1 domain
Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_7 (PF15269): Zinc-finger
63 IKZF4interactor100.6115.775ADK_lid (PF05191, IPR007862): Adenylate kinase, active site lid
PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
FancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease
64 JDP2suppressor50.5000.787bZIP_1 (PF00170, IPR004827): bZIP transcription factor
65 KDM5Binteractor70.6671.975ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
JmjN (PF02375, IPR003349, SM00545): jmjN domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PLU-1 (PF08429, IPR013637): PLU-1-like protein
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Rubredoxin (PF00301, IPR024935): Rubredoxin
zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger
Lipoprotein_20 (PF13942, IPR025262): YfhG lipoprotein
66 KLK13interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
67 KLK2oncoprotein2030.768Trypsin (PF00089, IPR001254, SM00020): Trypsin
68 KRT31interactor30.6670.500Filament (PF00038, IPR001664): Intermediate filament protein
69 KRT38interactor100Filament (PF00038, IPR001664): Intermediate filament protein
70 KRT40interactor30.6671.500Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
71 LAMC3interactor2016.955DUF1319 (PF07028, IPR010746): Protein of unknown function (DUF1319)
Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
OGFr_III (PF04680, IPR006770): Opioid growth factor receptor repeat
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF3774 (PF12609, IPR022251): Wound-induced protein
72 LCORinteractor60.6002.263DUF4553 (PF15090, IPR028104): Domain of unknown function (DUF4553)
73 LDOC1oncoprotein40.6670.486DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
74 LMNB1interactor50.300113.484Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
75 LZTR1oncoprotein31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
76 MAP1Sinteractor100Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain
77 MAPK1oncoprotein190.30762.806Pkinase (PF00069, IPR000719): Protein kinase domain
78 MAPK3oncoprotein100.44411.950Pkinase (PF00069, IPR000719): Protein kinase domain
79 MARK3protein found in more fusions110.9331.036KA1 (PF02149, IPR001772): Kinase associated domain 1
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
80 MECOMoncoprotein80.5716.391SET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
81 MEF2Aoncoprotein100.53315.008TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
82 MEF2Concoprotein100.44413.769SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
83 MEF2Doncoprotein70.5716.611DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
84 MIF4GDinteractor30.33368.678MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
85 MORC2interactor100Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
zf-CW (PF07496, IPR011124): CW-type Zinc Finger
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
86 MTUS2suppressor200DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496)
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
FAM184 (PF15665): Family with sequence similarity 184, A and B
87 NACC1interactor90.32114.613BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
BEN (PF10523, IPR018379, SM01025): BEN domain
88 NCOR1oncoprotein280.365151.490BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
89 NCOR2oncoprotein280.368148.759CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family
PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Spt20 (PF12090, IPR021950): Spt20 family
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
90 NFATC1oncoprotein80.5717.207RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
91 NFKB1suppressor200.3511112.599Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
92 NFKBIAoncoprotein100.62214.381Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
93 NFKBIEoncoprotein51.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
94 NPPBinteractor30.33320.730ANP (PF00212, IPR000663, SM00183): Atrial natriuretic peptide
95 NR1H2oncoprotein110.455252.111zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
96 NR2C1interactor70.8100.904zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
97 NR2C2suppressor80.7621.561Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
98 NUP155interactor30.6670.706Nucleoporin_C (PF03177, IPR007187): Non-repetitive/WGA-negative nucleoporin C-terminal
Nucleoporin_N (PF08801, IPR014908): Nup133 N terminal like
99 NUP214oncoprotein80.5245.293dCache_2 (PF08269, IPR004010, SM01049): Cache domain
HisKA (PF00512, IPR003661, SM00388): His Kinase A (phospho-acceptor) domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
Mustang (PF15682, IPR031394): Musculoskeletal, temporally activated-embryonic nuclear protein 1
NUP214 (PF16755): Nucleoporin or Nuclear pore complex subunit NUP214=Nup159
100 PARK2suppressor130.242122.339IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
101 PNMA1oncoprotein21.0000PNMA (PF14893, IPR026523): PNMA
102 PPARDoncoprotein70.8670.571zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
103 PPARGsuppressor200.33395.590zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
104 PPP2CAsuppressor80.50010.000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
105 PPP2R1Aoncoprotein80.5367.974TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
106 PSMA3interactor90.036157.630Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
107 PTPAsuppressor60.4009.506PTPA (PF03095, IPR004327): Phosphotyrosyl phosphate activator (PTPA) protein
108 RANBP2oncoprotein80.4297.734Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693)
IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain
Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
109 RARAoncoprotein140.53818.437zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
110 RBBP4oncoprotein180.35361.790eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
111 RESToncoprotein60.7330.933CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Presenilin (PF01080, IPR001108): Presenilin
RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
112 REV3Linteractor30.6671.000DNA_pol_B (PF00136, IPR006134): DNA polymerase family B
DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666)
DUF4683 (PF15735, IPR032757): Domain of unknown function (DUF4683)
113 RFX5oncoprotein70.57111.067RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain
RFX5_DNA_bdg (PF14621, IPR029298): RFX5 DNA-binding domain
114 RFXANKinteractor70.5334.292Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
115 RFXAPinteractor50.6003.400RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
116 RINT1suppressor100RINT1_TIP1 (PF04437, IPR007528): RINT-1 / TIP-1 family
117 RUNX2suppressor70.8101.434DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Runt (PF00853, IPR013524): Runt domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
118 RXRAoncoprotein190.47155.314zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
119 SENP1protein found in more fusions70.3339.201Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
120 SF1protein found in more fusions90.46440.471UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
121 SFNsuppressor130.54516.63214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
122 SIN3Aoncoprotein210.37168.037Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
123 SIRT1suppressor170.33360.532DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
124 SMAD3oncoprotein270.268164.524MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
125 SP1protein found in more fusions320.256235.569zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
126 SRFinteractor90.8212.503SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
127 SS18L1oncoprotein41.0000DUF1313 (PF07011, IPR009741): Protein of unknown function (DUF1313)
SSXT (PF05030, IPR007726): SSXT protein (N-terminal region)
128 STAT1suppressor110.44419.301SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
129 SUV39H1protein found in more fusions160.352204.324Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
130 SYKsuppressor60.6003.055Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
131 TBL1XR1oncoprotein120.51552.598LisH (PF08513, IPR013720, SM00667): LisH
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
132 TP53BP1suppressor60.40010.12853-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
133 UBE2Iinteractor410.163783.113UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
134 YWHABinteractor140.61520.43714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
135 YWHAEoncoprotein140.516268.94314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
136 YWHAGprotein found in more fusions170.53341.14414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
137 YWHAHprotein found in more fusions120.7645.65914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
138 YWHAQinteractor200.379214.13114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
139 YWHAZprotein found in more fusions190.45165.80214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
140 YY1protein found in more fusions120.38224.800zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
141 ZBTB16suppressor210.384213.376BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
142 ZBTB7Binteractor60.7000.500BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GAGA (PF09237, IPR015318): GAGA factor
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
143 ZEB2oncoprotein70.5246.369zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
Rubredoxin (PF00301, IPR024935): Rubredoxin
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-CCHC_5 (PF14787): GAG-polyprotein viral zinc-finger
144 ZNF354Ainteractor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
145 ZNRD1interactor2074.422RecR (PF02132, IPR023628): RecR protein
RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)

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