Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CLCN3, ASIC4 (from a repository: Thu Dec 8 04:02:06 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)12
The number (and %) of the onco-proteins5 (41.67 %)
The number (and %) of the tumor suppressors2 (16.67 %)
Total number of binary PPIs (saturation %)24 (36.36 %)
The number (and %) of affected PPIs11 (45.83 %)
The number of possible different fusions7
PPI diameter2
PPI radiusinf
The average degree of PPI2.833
Assortativity coefficient-0.2786
The network average Clustering coefficient0.522
The number (and %) of a zero Clustering coefficients4 (33.33 %)
The number (and %) of a zero Betweenness Centrality9 (75.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ASIC4,CLCN3 All fusions
Proteins found in more fusions CLCN3 (see 3 fusions); HSPB1 (see 4 fusions); ZDHHC17 (see 2 fusions); GOPC (see 2 fusions); LGALS3 (see 2 fusions); SLC9A3R1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ASIC4parental protein100ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
2 CLCN3parental protein100.19448.000CBS (PF00571, IPR000644, SM00116): CBS domain
Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel
3 CFTRsuppressor70.4009.000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
4 GOPConcoprotein31.0000DUF903 (PF06004, IPR010305): Bacterial protein of unknown function (DUF903)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF3209 (PF11483, IPR021577): Protein of unknown function (DUF3209)
5 HSPB1oncoprotein31.0000HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
6 LGALS3oncoprotein40.6671.000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
7 LGALS8interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
8 LGALS9interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
9 LYPD3oncoprotein100DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753)
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
10 PDZK1interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
11 SLC9A3R1suppressor41.0000EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
12 ZDHHC17protein found in more fusions200zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

B a c k    t o    T o p ⇑