Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins FTSJ3, MT-CO2 (from a repository: Thu Aug 15 17:35:36 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 144 The number (and %) of the onco-proteins 32 (22.22 %) The number (and %) of the tumor suppressors 15 (10.42 %) Total number of binary PPIs (saturation %) 1649 (16.02 %) The number (and %) of affected PPIs 142 (8.61 %) The number of possible different fusions 23 PPI diameter 4 PPI radius 3 The average degree of PPI 22.375 Assortativity coefficient -0.0662 The network average Clustering coefficient 0.507 The number (and %) of a zero Clustering coefficients 3 (2.08 %) The number (and %) of a zero Betweenness Centrality 10 (6.94 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: MT-CO2,FTSJ3	All fusions
Proteins found in more fusions	UBE2O (see 2 fusions); GRK5 (see 2 fusions); NPM1 (see 1 fusions); CUL7 (see 2 fusions); DCAF1 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); BCAP31 (see 3 fusions); EIF2AK2 (see 1 fusions); COPS5 (see 1 fusions); DHX8 (see 1 fusions); SET (see 1 fusions); SAT1 (see 6 fusions); FANCG (see 1 fusions); NAP1L4 (see 3 fusions); RPL5 (see 1 fusions); MT-CO2/MT-CO1 (see 1 fusions); EGFR (see 2 fusions); DKC1 (see 2 fusions); CSNK2A1 (see 2 fusions); FN1/RPL6 (see 1 fusions); DDB1 (see 4 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	MT-CO2	parental protein	43	0.185	2097.174	COX2 (PF00116, IPR002429): Cytochrome C oxidase subunit II, periplasmic domain COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain
2	FTSJ3	parental protein	99	0.219	3187.795	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase M16C_assoc (PF08367, IPR013578): Peptidase M16C associated Orthopox_F8 (PF05886, IPR008726): Orthopoxvirus F8 protein Spb1_C (PF07780, IPR012920): Spb1 C-terminal domain DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381) RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
3	ABT1	interactor	2	1.000	0	T2SS-T3SS_pil_N (PF13629, IPR032789): Pilus formation protein N terminal region
4	ATAD3B	interactor	10	0.400	19.609	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) TsaE (PF02367, IPR003442): Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF3523 (PF12037, IPR021911): Domain of unknown function (DUF3523)
5	ATP2B3	interactor	4	0.500	5.895	Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase ATP_Ca_trans_C (PF12424, IPR022141): Plasma membrane calcium transporter ATPase C terminal Cation_ATPase (PF13246): Cation transport ATPase (P-type)
6	ATP5C1	interactor	18	0.542	32.760	ATP-synt (PF00231, IPR000131): ATP synthase ACT_4 (PF13291, IPR002912): ACT domain
7	ATP5F1	interactor	13	0.449	23.985	Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
8	BCAP31	protein found in more fusions	9	0.750	7.502	Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
9	BRIX1	interactor	40	0.456	264.910	Brix (PF04427, IPR007109, SM00879): Brix domain
10	BYSL	interactor	13	0.423	20.802	Bystin (PF05291, IPR007955): Bystin MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
11	CAND1	interactor	60	0.303	776.476	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
12	CANX	interactor	20	0.368	163.500	Calreticulin (PF00262, IPR001580): Calreticulin family DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
13	CBX8	interactor	15	0.615	9.982	Atrophin-1 (PF03154, IPR002951): Atrophin-1 family Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain RBR (PF17208): RNA binding Region CBX7_C (PF17218): CBX family C-terminal motif
14	CDC5L	interactor	33	0.367	212.311	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
15	CDK2	suppressor	30	0.379	245.195	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
16	CLTC	oncoprotein	28	0.423	119.791	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS Clathrin_H_link (PF13838): Clathrin-H-link
17	COPS5	protein found in more fusions	41	0.464	180.214	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
18	COX20	interactor	1	0	0	DUF3767 (PF12597, IPR022533): Protein of unknown function (DUF3767)
19	COX4I1	interactor	15	0.457	58.733	COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
20	COX5B	interactor	2	1.000	0	COX5B (PF01215, IPR002124): Cytochrome c oxidase subunit Vb
21	CSNK2A1	oncoprotein	30	0.335	152.879	Pkinase (PF00069, IPR000719): Protein kinase domain
22	CUL1	suppressor	40	0.451	186.994	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
23	CUL3	protein found in more fusions	61	0.304	694.852	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
24	CUL7	protein found in more fusions	47	0.320	726.246	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
25	DCAF1	protein found in more fusions	11	0.644	4.004	DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) LisH (PF08513, IPR013720, SM00667): LisH ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
26	DDB1	protein found in more fusions	19	0.353	70.239	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
27	DDOST	interactor	21	0.514	51.964	DDOST_48kD (PF03345, IPR005013): Oligosaccharyltransferase 48 kDa subunit beta
28	DDX21	interactor	29	0.468	106.535	CRT10 (PF08728, IPR014839): CRT10 DEAD (PF00270, IPR011545): DEAD/DEAH box helicase GUCT (PF08152, IPR012562): GUCT (NUC152) domain Sulfatase (PF00884, IPR000917): Sulfatase MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
29	DDX24	interactor	41	0.541	129.253	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain Sec62 (PF03839, IPR004728): Translocation protein Sec62 Tti2 (PF10521, IPR018870): Tti2 family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
30	DDX27	interactor	35	0.494	95.028	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
31	DDX56	interactor	33	0.583	40.348	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
32	DEK	oncoprotein	14	0.429	12.716	DEK_C (PF08766, IPR014876): DEK C terminal domain Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family SAP (PF02037, IPR003034, SM00513): SAP domain Bud13 (PF09736, IPR018609): Pre-mRNA-splicing factor of RES complex DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
33	DHX8	protein found in more fusions	11	0.622	2.862	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
34	DKC1	oncoprotein	36	0.469	152.752	DKCLD (PF08068, IPR012960, SM01136): DKCLD (NUC011) domain PUA (PF01472, IPR002478, SM00359): PUA domain RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 TruB_N (PF01509, IPR002501): TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 (PF16198, IPR032819): tRNA pseudouridylate synthase B C-terminal domain
35	EBNA1BP2	interactor	45	0.487	145.866	Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2
36	ECT2	suppressor	7	0.286	35.659	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
37	EED	suppressor	44	0.303	373.946	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
38	EGFR	oncoprotein	22	0.262	164.947	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
39	EIF2AK2	oncoprotein	13	0.697	8.259	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Pkinase (PF00069, IPR000719): Protein kinase domain
40	EIF2B4	interactor	8	0.643	7.873	IF-2B (PF01008, IPR000649): Initiation factor 2 subunit family Mpp10 (PF04006, IPR007151): Mpp10 protein
41	EIF5B	interactor	10	0.422	20.750	GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 MIase (PF02426, IPR026029): Muconolactone delta-isomerase NOA36 (PF06524, IPR010531): NOA36 protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306) IF-2 (PF11987, IPR023115): Translation-initiation factor 2 DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807) GTP_EFTU_D4 (PF14578, IPR029459): Elongation factor Tu domain 4 DUF4632 (PF15451, IPR027952): Domain of unknown function (DUF4632) Coilin_N (PF15862, IPR031722): Coilin N-terminus DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
42	ESR1	suppressor	34	0.430	103.818	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
43	FAF2	interactor	15	0.286	101.233	DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) UBX (PF00789, IPR001012, SM00166): UBX domain Thioredoxin_7 (PF13899): Thioredoxin-like UBA_4 (PF14555): UBA-like domain
44	FANCG	suppressor	3	0	77.413	BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain Hpt (PF01627, IPR008207, SM00073): Hpt domain TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
45	FBL	interactor	43	0.508	153.761	Fibrillarin (PF01269, IPR000692): Fibrillarin
46	FN1	oncoprotein	33	0.305	404.514	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
47	GNL3	interactor	35	0.600	68.756	GN3L_Grn1 (PF08701, IPR014813): GNL3L/Grn1 putative GTPase GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family FAM176 (PF14851): FAM176 family
48	GNL3L	interactor	6	0.667	0.655	DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258 GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
49	GPD2	interactor	5	0.300	5.321	DAO (PF01266, IPR006076): FAD dependent oxidoreductase EF-hand_7 (PF13499, IPR011992): EF-hand domain pair DAO_C (PF16901, IPR031656): C-terminal domain of alpha-glycerophosphate oxidase
50	GRK5	protein found in more fusions	11	0.356	10.711	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
51	HIST1H1A	interactor	24	0.380	86.321	Mucin (PF01456, IPR000458): Mucin-like glycoprotein Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
52	HNRNPU	interactor	59	0.352	578.281	CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
53	HP1BP3	interactor	22	0.494	36.766	RXT2_N (PF08595, IPR013904): RXT2-like, N-terminal SDA1 (PF05285, IPR007949): SDA1 YL1 (PF05764, IPR008895): YL1 nuclear protein Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
54	HSP90B1	suppressor	23	0.447	105.981	CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
55	HSPB2	interactor	3	1.000	0	Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
56	IFI16	suppressor	34	0.326	114.355	HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
57	ILF2	interactor	39	0.453	184.746	DZF (PF07528, IPR006561, SM00572): DZF domain
58	LGR4	interactor	17	0.317	127.108	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
59	LIG4	interactor	2	1.000	0	APG17 (PF04108, IPR007240): Autophagy protein Apg17 BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
60	LTV1	interactor	7	0.667	3.614	DUF1874 (PF08960, IPR015055): Domain of unknown function (DUF1874) LTV (PF04180, IPR007307): Low temperature viability protein
61	MAGEB4	interactor	2	1.000	0	MAGE (PF01454, IPR002190): MAGE family Pap_E4 (PF02711, IPR003861): E4 protein MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
62	MAGT1	interactor	12	0.394	54.411	OST3_OST6 (PF04756, IPR021149): OST3 / OST6 family, transporter family
63	MAK16	interactor	6	0.733	0.732	Mak16 (PF04874, IPR006958): Mak16 protein C-terminal region Ribosomal_L28e (PF01778, IPR029004): Ribosomal L28e protein family Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
64	MPHOSPH10	interactor	15	0.638	11.219	Mpp10 (PF04006, IPR007151): Mpp10 protein
65	MRPL58	interactor	18	0.314	115.851	RF-1 (PF00472, IPR000352): RF-1 domain
66	MRTO4	interactor	28	0.571	63.047	Glu_syn_central (PF04898, IPR006982): Glutamate synthase central domain Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
67	MT-CO1	protein found in more fusions	4	0.500	3.000	DUF3485 (PF11984, IPR014263): Protein of unknown function (DUF3485)
68	MYBBP1A	suppressor	32	0.526	70.794	DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi Pol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal
69	NAP1L4	protein found in more fusions	11	0.622	3.842	NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
70	NCSTN	interactor	12	0.591	20.546	Nicastrin (PF05450, IPR008710): Nicastrin Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
71	NDUFS1	interactor	14	0.440	60.238	NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal Fer4 (PF00037, IPR001450): 4Fe-4S binding domain Molybdopterin (PF00384, IPR006656): Molybdopterin oxidoreductase NADH-G_4Fe-4S_3 (PF10588, IPR019574, SM00929): NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2_4 (PF13510): 2Fe-2S iron-sulfur cluster binding domain
72	NDUFV2	interactor	5	0.700	1.224	2Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
73	NELFCD	oncoprotein	4	0.333	66.935	TH1 (PF04858, IPR006942): TH1 protein
74	NFIA	interactor	8	0.821	0.762	CTF_NFI (PF00859, IPR000647): CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N (PF10524, IPR019548): Nuclear factor I protein pre-N-terminus MH1 (PF03165, IPR003619, SM00523): MH1 domain
75	NIFK	interactor	41	0.527	98.878	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) hNIFK_binding (PF12196, IPR021043): FHA Ki67 binding domain of hNIFK
76	NLGN3	interactor	3	0.333	36.715	COesterase (PF00135, IPR002018): Carboxylesterase family Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
77	NOB1	interactor	6	0.800	0.739	NOB1_Zn_bind (PF08772, IPR014881): Nin one binding (NOB1) Zn-ribbon like WRNPLPNID (PF15017): Putative WW-binding domain and destruction box PIN_6 (PF17146): PIN domain of ribonuclease
78	NOC2L	interactor	27	0.689	18.632	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi Noc2 (PF03715, IPR005343): Noc2p family CEND1 (PF15677, IPR020162): Cell cycle exit and neuronal differentiation protein 1
79	NOL12	interactor	17	0.640	18.171	DUF2357 (PF09823, IPR018633): Domain of unknown function (DUF2357) Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
80	NOP2	interactor	56	0.451	274.473	BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II) Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F P120R (PF08062, IPR012586): P120R (NUC006) repeat Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein DUF2477 (PF10631, IPR018904): Protein of unknown function (DUF2477) FAM176 (PF14851): FAM176 family Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
81	NOP56	interactor	54	0.428	232.747	Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
82	NOP58	interactor	35	0.558	72.272	Cellulose_synt (PF03552, IPR005150): Cellulose synthase Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
83	NPM1	suppressor	62	0.353	582.511	Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
84	NSA2	oncoprotein	22	0.701	13.292	Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
85	NTRK1	oncoprotein	77	0.204	2075.175	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
86	OAS3	interactor	4	0.667	2.261	NTP_transf_2 (PF01909, IPR002934): Nucleotidyltransferase domain OAS1_C (PF10421, IPR018952): 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
87	OBSL1	interactor	46	0.372	197.951	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
88	PAIP1	interactor	4	1.000	0	MIF4G (PF02854, IPR003890, SM00543): MIF4G domain PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
89	PES1	interactor	37	0.527	89.000	Pescadillo_N (PF06732, IPR010613): Pescadillo N-terminus RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 DUF3347 (PF11827, IPR021782): Protein of unknown function (DUF3347) U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
90	PHB	suppressor	23	0.368	139.514	Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
91	PRR11	interactor	19	0.520	15.361	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator PRIMA1 (PF16101): Proline-rich membrane anchor 1
92	PSIP1	oncoprotein	11	0.618	4.104	AT_hook (PF02178, IPR017956, SM00384): AT hook motif BEX (PF04538, IPR021156): Brain expressed X-linked like family DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) PGA2 (PF07543, IPR011431): Protein trafficking PGA2 PWWP (PF00855, IPR000313, SM00293): PWWP domain LEDGF (PF11467, IPR021567): Lens epithelium-derived growth factor (LEDGF) TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2
93	PSMA1	interactor	7	0.400	29.699	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
94	PSMC2	interactor	13	0.439	34.392	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
95	PSMC4	interactor	8	0.643	11.143	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) NTPase_1 (PF03266, IPR004948): NTPase CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_16 (PF13191): AAA ATPase domain
96	PUM3	interactor	37	0.593	59.466	CPL (PF08144, IPR012959): CPL (NUC119) domain
97	PWP1	interactor	18	0.556	16.012	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
98	RAB1B	oncoprotein	6	0.667	3.395	Ras (PF00071, IPR001806, SM00173): Ras family
99	RAD21	oncoprotein	13	0.359	80.965	Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
100	RBM14	suppressor	18	0.438	34.207	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
101	RBM19	interactor	10	0.533	7.251	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A Integrase_AP2 (PF14657, IPR028259): AP2-like DNA-binding integrase domain
102	RBM34	oncoprotein	18	0.490	21.654	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3139 (PF11337, IPR021486): Protein of unknown function (DUF3139)
103	RBM4B	interactor	7	0.571	2.282	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC (PF00098, IPR001878): Zinc knuckle
104	RIDA	interactor	2	0	0	Ribonuc_L-PSP (PF01042, IPR006175): Endoribonuclease L-PSP
105	RNF2	interactor	52	0.244	636.037	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
106	RPF2	interactor	26	0.609	35.308	Brix (PF04427, IPR007109, SM00879): Brix domain
107	RPL10	suppressor	47	0.440	239.364	Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
108	RPL14	interactor	44	0.537	114.060	KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14 UPF0688 (PF15772, IPR031530): UPF0688 family
109	RPL18A	interactor	31	0.680	19.784	Ribosomal_L18A (PF01775, IPR023573): Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
110	RPL31	interactor	27	0.621	22.836	Ribosomal_L31e (PF01198, IPR000054): Ribosomal protein L31e
111	RPL39	interactor	3	1.000	0	Ribosomal_L39 (PF00832, IPR000077): Ribosomal L39 protein
112	RPL4	interactor	36	0.590	96.009	Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
113	RPL5	suppressor	46	0.514	175.195	Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
114	RPL6	protein found in more fusions	42	0.537	149.302	Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain
115	RPL8	interactor	34	0.633	37.329	Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
116	RPL9	interactor	29	0.640	67.811	Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6
117	RPN1	oncoprotein	28	0.370	177.535	Ribophorin_I (PF04597, IPR007676): Ribophorin I CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
118	RRS1	interactor	37	0.473	135.464	GRP (PF07172, IPR010800): Glycine rich protein family RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 RRS1 (PF04939, IPR007023): Ribosome biogenesis regulatory protein (RRS1)
119	SAT1	protein found in more fusions	3	1.000	0	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
120	SDHB	suppressor	13	0.359	72.259	Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain Fer4_17 (PF13534): 4Fe-4S dicluster domain
121	SET	oncoprotein	7	0.400	3.578	NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) Nop14 (PF04147, IPR007276): Nop14-like family DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
122	SF3B6	interactor	8	0.536	3.120	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
123	SIRT7	interactor	58	0.276	627.426	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
124	SLC25A3	interactor	22	0.411	132.306	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
125	SRP68	interactor	14	0.571	11.044	RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB SRP68 (PF16969, IPR026258): RNA-binding signal recognition particle 68
126	SRP72	interactor	16	0.608	16.862	BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain TPR_12 (PF13424): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat SRP_TPR_like (PF17004, IPR031545): Putative TPR-like repeat
127	SRPK3	interactor	11	0.618	3.629	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein Pkinase (PF00069, IPR000719): Protein kinase domain
128	SSR1	interactor	15	0.457	70.381	TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
129	SSR4	interactor	16	0.417	132.510	TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta) OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
130	SURF2	interactor	4	0.833	0.080	SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
131	TBL3	interactor	20	0.611	26.167	SdiA-regulated (PF06977, IPR009722): SdiA-regulated Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_like (PF17005, IPR031544): WD40-like domain
132	TSR1	interactor	16	0.417	51.442	AARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
133	U2AF1	oncoprotein	21	0.467	43.908	DUF1509 (PF07420, IPR010883): Protein of unknown function (DUF1509) KMP11 (PF03037, IPR004132): Kinetoplastid membrane protein 11 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
134	UBE2O	protein found in more fusions	8	0.286	25.295	BUD22 (PF09073, IPR015158): BUD22 UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
135	UQCRC2	oncoprotein	22	0.420	99.955	Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16) Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
136	UTP14A	interactor	27	0.370	165.320	Utp14 (PF04615, IPR006709): Utp14 protein
137	VDAC1	interactor	17	0.566	42.403	Porin_3 (PF01459, IPR027246): Eukaryotic porin
138	VDAC2	interactor	20	0.447	113.621	Porin_3 (PF01459, IPR027246): Eukaryotic porin
139	VDAC3	interactor	22	0.403	121.573	Porin_3 (PF01459, IPR027246): Eukaryotic porin
140	WDR12	interactor	15	0.670	9.143	NLE (PF08154, IPR012972): NLE (NUC135) domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
141	YME1L1	interactor	5	0.700	3.685	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
142	YWHAE	oncoprotein	15	0.600	43.497	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
143	ZC3H3	interactor	13	0.551	8.225	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family
144	ZNF622	interactor	10	0.694	5.713	S-antigen (PF05756, IPR008825): S-antigen protein Stm1_N (PF09598, IPR019084): Stm1 TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)

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