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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DNTTIP1, WFDC3 (from a repository: Mon Aug 5 05:27:35 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins7 (23.33 %)
The number (and %) of the tumor suppressors4 (13.33 %)
Total number of binary PPIs (saturation %)82 (18.85 %)
The number (and %) of affected PPIs29 (35.37 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI4.733
Assortativity coefficient-0.4066
The network average Clustering coefficient0.557
The number (and %) of a zero Clustering coefficients7 (23.33 %)
The number (and %) of a zero Betweenness Centrality16 (53.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DNTTIP1,WFDC3 All fusions
Proteins found in more fusions KDM1A (see 3 fusions); RPA1 (see 1 fusions); EWSR1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DNTTIP1parental protein290.114589.367DUF4385 (PF14328, IPR025494): Domain of unknown function (DUF4385)
2 WFDC3interactor000NA
3 ABTB1interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
4 CCNA2oncoprotein70.4676.733Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
5 CLCN2interactor100CBS (PF00571, IPR000644, SM00116): CBS domain
Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel
6 DNTTinteractor100BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
NTP_transf_2 (PF01909, IPR002934): Nucleotidyltransferase domain
DNA_pol_lambd_f (PF10391, IPR018944): Fingers domain of DNA polymerase lambda
HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
DNA_pol_B_thumb (PF14791, IPR029398): DNA polymerase beta thumb
DNA_pol_B_palm (PF14792, IPR028207): DNA polymerase beta palm
7 EIF2S1interactor60.7333.667EIF_2_alpha (PF07541, IPR011488): Eukaryotic translation initiation factor 2 alpha subunit
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
8 ELMSAN1interactor90.47214.233ELM2 (PF01448, IPR000949): ELM2 domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
9 EWSR1oncoprotein70.7332.400RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
10 FOXJ2interactor21.0000SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
11 HDAC1suppressor80.6195.667FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
12 HDAC2suppressor100.41716.800Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
13 HIST1H2BGoncoprotein21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
14 HIST1H3Ainteractor51.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
15 HOMEZinteractor21.0000Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
PRIMA1 (PF16101): Proline-rich membrane anchor 1
16 KDM1Aprotein found in more fusions80.5716.400Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
17 KRASoncoprotein50.5002.167Ras (PF00071, IPR001806, SM00173): Ras family
18 NANOGinteractor31.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
19 NEFMinteractor100ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
20 PLK2suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
21 POLR2Finteractor100RNA_pol_Rpb6 (PF01192, IPR006110): RNA polymerase Rpb6
22 PYM1interactor21.0000CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
Mago-bind (PF09282, IPR015362): Mago binding
AAA_23 (PF13476): AAA domain
23 RPA1suppressor90.6435.633Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
24 RPA2oncoprotein80.6077.133RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
25 RPA3interactor80.7622.133Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
26 SH3RF2interactor21.0000SH3_2 (PF07653, IPR011511): Variant SH3 domain
TUDOR (PF00567, IPR002999, SM00333): Tudor domain
UPF0547 (PF10571, IPR018886): Uncharacterised protein family UPF0547
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
SH3_9 (PF14604, IPR001452): Variant SH3 domain
27 TFAP4oncoprotein41.0000DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
28 TRERF1interactor40.6672.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
ELM2 (PF01448, IPR000949): ELM2 domain
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681)
MCRS_N (PF13325, IPR025999): N-terminal region of micro-spherule protein
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
PRIMA1 (PF16101): Proline-rich membrane anchor 1
29 WDFY2interactor100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
30 XPO1interactor50.4005.667CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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