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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CHRM3, FLT3 (from a repository: Wed Aug 14 02:56:08 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins7 (43.75 %)
The number (and %) of the tumor suppressors5 (31.25 %)
Total number of binary PPIs (saturation %)35 (29.17 %)
The number (and %) of affected PPIs15 (42.86 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI3.125
Assortativity coefficient0.2240
The network average Clustering coefficient0.520
The number (and %) of a zero Clustering coefficients5 (31.25 %)
The number (and %) of a zero Betweenness Centrality8 (50.00 %)


List of the fusions

PPI for parental proteins: CHRM3,FLT3 All fusions
Proteins found in more fusions SET (see 1 fusions); PIK3R1 (see 1 fusions); ARF1 (see 2 fusions); UBE2L6 (see 2 fusions); HSP90AA1 (see 6 fusions); GRB2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CHRM3parental protein4078.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
GWT1 (PF06423, IPR009447): GWT1
2 FLT3parental protein110.222115.667I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
3 ARF1suppressor200Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
4 ARF6oncoprotein100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
5 CBLsuppressor50.6672.000Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
6 CSNK1A1suppressor2088.000Pkinase (PF00069, IPR000719): Protein kinase domain
7 GRB2oncoprotein60.60018.667SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
8 HSP90AA1oncoprotein50.333101.000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
9 IKBKGinteractor31.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
10 PIK3R1oncoprotein50.8330.667RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
11 SEToncoprotein200NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
Nop14 (PF04147, IPR007276): Nop14-like family
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
12 SIAH1suppressor31.0000Sina (PF03145, IPR018121): Seven in absentia protein family
13 SLAinteractor21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
14 SOCS1suppressor40.6672.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
15 SOCS2oncoprotein21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
16 UBE2L6protein found in more fusions31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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