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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CHRM3, RCL1 (from a repository: Wed Feb 14 01:51:38 2018)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)22
The number (and %) of the onco-proteins4 (18.18 %)
The number (and %) of the tumor suppressors6 (27.27 %)
Total number of binary PPIs (saturation %)52 (22.51 %)
The number (and %) of affected PPIs20 (38.46 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI3.818
Assortativity coefficient-0.1989
The network average Clustering coefficient0.384
The number (and %) of a zero Clustering coefficients8 (36.36 %)
The number (and %) of a zero Betweenness Centrality8 (36.36 %)


List of the fusions

PPI for parental proteins: RCL1,CHRM3 All fusions
Proteins found in more fusions ARF1 (see 2 fusions); USF1 (see 3 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 RCL1parental protein160.167251.000RTC (PF01137, IPR023797): RNA 3'-terminal phosphate cyclase
2 CHRM3parental protein4079.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
GWT1 (PF06423, IPR009447): GWT1
3 ARF1suppressor200Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
4 ARF6oncoprotein100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
5 BRCA1suppressor50.6671.333BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
6 CSNK1A1suppressor2051.000Pkinase (PF00069, IPR000719): Protein kinase domain
7 EEDsuppressor60.7001.667WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
8 GEMIN7interactor100Gemin7 (PF11095, IPR020338): Gem-associated protein 7 (Gemin7)
SUZ-C (PF12901, IPR024642): SUZ-C motif
9 HDGFinteractor40.5002.667PWWP (PF00855, IPR000313, SM00293): PWWP domain
10 HECW2interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
11 HIST1H3Einteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
12 IFI16suppressor40.5002.500HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
13 MOV10interactor40.5002.333AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
14 NXF1interactor80.38128.000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
15 PAPD5interactor100NTP_transf_2 (PF01909, IPR002934): Nucleotidyltransferase domain
PAP_assoc (PF03828, IPR002058): Cid1 family poly A polymerase
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
16 RNF2interactor70.40023.000zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
17 SEToncoprotein3051.000NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
Nop14 (PF04147, IPR007276): Nop14-like family
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
18 SIRT7interactor40.6674.667DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
19 SUZ12suppressor60.7001.667DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
20 TFGoncoprotein31.0000ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
MucBP (PF06458, IPR009459): MucBP domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
21 USF1oncoprotein200HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
22 XPO1interactor60.267162.167CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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