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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CHRM3, CDKN2B-AS1 (from a repository: Mon Sep 16 14:31:43 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)7
The number (and %) of the onco-proteins2 (28.57 %)
The number (and %) of the tumor suppressors3 (42.86 %)
Total number of binary PPIs (saturation %)8 (38.10 %)
The number (and %) of affected PPIs5 (62.50 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI1.429
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients7 (100.00 %)
The number (and %) of a zero Betweenness Centrality6 (85.71 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CHRM3,CDKN2B-AS1 All fusions
Proteins found in more fusions ARF1 (see 2 fusions); SET (see 1 fusions); EZH2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CHRM3parental protein4012.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
GWT1 (PF06423, IPR009447): GWT1
2 CDKN2B-AS1parental protein100NA
3 ARF1suppressor200Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
4 ARF6oncoprotein100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
5 CSNK1A1suppressor100Pkinase (PF00069, IPR000719): Protein kinase domain
6 EZH2suppressor200CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
7 SEToncoprotein200NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
Nop14 (PF04147, IPR007276): Nop14-like family
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)

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