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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LYST, ZFYVE26 (from a repository: Wed Dec 11 18:56:05 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)55
The number (and %) of the onco-proteins11 (20.00 %)
The number (and %) of the tumor suppressors1 (1.82 %)
Total number of binary PPIs (saturation %)116 (7.81 %)
The number (and %) of affected PPIs53 (45.69 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI3.527
Assortativity coefficient-0.4974
The network average Clustering coefficient0.362
The number (and %) of a zero Clustering coefficients22 (40.00 %)
The number (and %) of a zero Betweenness Centrality32 (58.18 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ZFYVE26,LYST All fusions
Proteins found in more fusions KPNB1 (see 2 fusions); ATN1 (see 1 fusions); ALAS1 (see 1 fusions); YWHAZ (see 1 fusions); HNRNPC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ZFYVE26parental protein190.070735.289FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
2 LYSTparental protein340.0272027.872Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4800 (PF16057): Domain of unknown function (DUF4800)
3 ALAS1protein found in more fusions200Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
Preseq_ALAS (PF09029, IPR015118): 5-aminolevulinate synthase presequence
4 ATN1protein found in more fusions50.167199.077Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
5 CELF4interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TF_Otx (PF03529, IPR013851): Otx1 transcription factor
RRM_7 (PF16367, IPR000504): RNA recognition motif
6 CENPJinteractor50.50081.976DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF1795 (PF08786, IPR014894): Domain of unknown function (DUF1795)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Rota_VP2 (PF05087, IPR007779): Rotavirus VP2 protein
Tcp10_C (PF07202, IPR009852): T-complex protein 10 C-terminus
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
AAA_23 (PF13476): AAA domain
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
7 CEP44interactor21.0000DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Utp12 (PF04003, IPR007148): Dip2/Utp12 Family
CEP44 (PF15007, IPR029157): Centrosomal spindle body, CEP44
8 CNTROBinteractor100DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
FadA (PF09403, IPR018543): Adhesion protein FadA
Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
9 CSNK2Binteractor200CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
10 DAP3interactor31.0000DAP3 (PF10236, IPR019368): Mitochondrial ribosomal death-associated protein 3
11 DGCR14interactor100Es2 (PF09751, IPR019148): Nuclear protein Es2
12 DNAJC14interactor100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Jiv90 (PF14901, IPR032843): Cleavage inducing molecular chaperone
13 EFSinteractor100DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
14 ESRRAoncoprotein100zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
15 GAR1interactor21.0000Gar1 (PF04410, IPR007504): Gar1/Naf1 RNA binding region
16 GOLGA2interactor2038.324ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
17 HGSinteractor60.200208.082FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
18 HNRNPCprotein found in more fusions50.33370.789APG6 (PF04111, IPR007243): Autophagy protein Apg6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
19 HNRNPH2interactor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
20 HNRNPMinteractor40.33392.952RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M
Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
21 KIF1Cinteractor41.0000FHA (PF00498, IPR000253, SM00240): FHA domain
IncA (PF04156, IPR007285): IncA protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
22 KLC3interactor40.33384.685TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TPR_12 (PF13424): Tetratricopeptide repeat
23 KPNB1protein found in more fusions31.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
24 KRT15interactor50.40058.761Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
25 KRT40interactor40.50026.266Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
26 KRTAP10-3interactor41.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
27 KRTAP10-7interactor50.66722.800Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
28 KRTAP10-9interactor41.0000Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
29 LLGL2interactor200Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal
LLGL (PF08366, IPR013577): LLGL2
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
30 MDFIinteractor3027.224MDFI (PF15316, IPR026134): MyoD family inhibitor
31 MED12oncoprotein2032.928Med12 (PF09497, IPR019035): Transcription mediator complex subunit Med12
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877)
Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain
Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
32 MLH1suppressor21.0000DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
33 MRPL17interactor100Ribosomal_L17 (PF01196, IPR000456): Ribosomal protein L17
COMP (PF11598, IPR024665): Cartilage oligomeric matrix protein
34 MRPS31interactor21.0000MRP-S31 (PF15433, IPR026299): Mitochondrial 28S ribosomal protein S31
35 MYH13interactor30.33374.824IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
36 NCDNinteractor100Neurochondrin (PF05536, IPR008709): Neurochondrin
37 PCBP4interactor100KH_1 (PF00013, IPR004088, SM00322): KH domain
38 PNMA1oncoprotein30.33382.632PNMA (PF14893, IPR026523): PNMA
39 PNMA5interactor31.0000PNMA (PF14893, IPR026523): PNMA
40 PPIAinteractor100Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
41 SAP30interactor21.0000Titin_Z (PF09042, IPR015129): Titin Z
zf-SAP30 (PF13866, IPR025717): SAP30 zinc-finger
SAP30_Sin3_bdg (PF13867, IPR025718): Sin3 binding region of histone deacetylase complex subunit SAP30
42 SPAG5interactor30.33377.654CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1307 (PF06998, IPR009736): Protein of unknown function (DUF1307)
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
DUF3573 (PF12097, IPR021956): Protein of unknown function (DUF3573)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4266 (PF14086, IPR025362): Domain of unknown function (DUF4266)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
43 SSX2IPinteractor90.214252.916ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
44 TACC1oncoprotein100TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
45 TADA2Ainteractor50.200112.441SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
46 TDO2interactor200Trp_dioxygenase (PF03301, IPR004981): Tryptophan 2,3-dioxygenase
47 TFIP11interactor21.0000G-patch (PF01585, IPR000467, SM00443): G-patch domain
GCFC (PF07842, IPR022783): GC-rich sequence DNA-binding factor-like protein
TIP_N (PF12457, IPR022159): Tuftelin interacting protein N terminal
48 TNNI3interactor100Troponin (PF00992, IPR001978): Troponin
Troponin-I_N (PF11636, IPR021666): Troponin I residues 1-32
49 TRAF1oncoprotein200HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
50 USHBP1interactor60.50054.689DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
51 VTA1interactor100Vta1 (PF04652): Vta1 like
52 YWHABinteractor60.6009.39014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
53 YWHAQinteractor70.381146.67414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
54 YWHAZprotein found in more fusions80.476215.75514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
55 ZNF521oncoprotein100zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
zf-met (PF12874): Zinc-finger of C2H2 type
zf-met2 (PF12907): Zinc-binding
zf-ribbon_3 (PF13248): zinc-ribbon domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zinc_ribbon_9 (PF14369): zinc-ribbon
Zf_RING (PF16744, IPR031946): KIAA1045 RING finger

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