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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KLHL2, LINC00871 (from a repository: Tue May 15 15:38:56 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins3 (12.50 %)
The number (and %) of the tumor suppressors2 (8.33 %)
Total number of binary PPIs (saturation %)42 (15.22 %)
The number (and %) of affected PPIs23 (54.76 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI2.583
Assortativity coefficient-0.1641
The network average Clustering coefficient0.402
The number (and %) of a zero Clustering coefficients12 (50.00 %)
The number (and %) of a zero Betweenness Centrality20 (83.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LINC00871,KLHL2 All fusions
Proteins found in more fusions CUL3 (see 1 fusions); UBE2C (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LINC00871interactor000NA
2 KLHL2parental protein230.039427.000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
3 ACTC1interactor100Actin (PF00022, IPR004000, SM00268): Actin
4 BCAMinteractor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
SKG6 (PF08693, IPR014805): Transmembrane alpha-helix domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
5 CCDC43interactor100ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
DUF2247 (PF10004, IPR016630): Uncharacterized protein conserved in bacteria (DUF2247)
6 CLK2interactor31.0000DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-met (PF12874): Zinc-finger of C2H2 type
7 CUL3protein found in more fusions80.28615.000Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
8 DCTN2interactor31.0000Dynamitin (PF04912): Dynamitin
9 KEAP1oncoprotein31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
10 KLHL12interactor40.6671.000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
11 NACC1interactor31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
BEN (PF10523, IPR018379, SM01025): BEN domain
12 SDCBPinteractor30.6671.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
13 TMA16interactor100Tma16 (PF11176, IPR021346): Translation machinery-associated protein 16
14 TNPO2interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Dopey_N (PF04118, IPR007249): Dopey, N-terminal
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
DUF2573 (PF10835, IPR020393): Protein of unknown function (DUF2573)
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
15 TSPAN5interactor100Tetraspannin (PF00335, IPR018499): Tetraspanin family
16 TXNDC12interactor100Thioredoxin_7 (PF13899): Thioredoxin-like
17 UBE2Concoprotein200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
18 UBE2D1interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
19 WNK1interactor31.0000SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist
Pkinase (PF00069, IPR000719): Protein kinase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
20 WNK2suppressor21.0000DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Pkinase (PF00069, IPR000719): Protein kinase domain
PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
21 WNK3interactor100DP (PF08781, IPR014889, SM01138): Transcription factor DP
Pkinase (PF00069, IPR000719): Protein kinase domain
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
PHtD_u1 (PF16645): Unstructured region on Pneumococcal histidine triad protein
22 WNK4interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
23 ZFP36suppressor100zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
24 ZNF114interactor200HNH (PF01844, IPR002711): HNH endonuclease
KRAB (PF01352, IPR001909, SM00349): KRAB box
PKI (PF02827, IPR004171): cAMP-dependent protein kinase inhibitor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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