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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRAF2, TPP1 (from a repository: Fri Jul 19 11:52:06 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins8 (29.63 %)
The number (and %) of the tumor suppressors3 (11.11 %)
Total number of binary PPIs (saturation %)54 (15.38 %)
The number (and %) of affected PPIs25 (46.30 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI3.407
Assortativity coefficient-0.2653
The network average Clustering coefficient0.344
The number (and %) of a zero Clustering coefficients10 (37.04 %)
The number (and %) of a zero Betweenness Centrality11 (40.74 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions EGFR (see 2 fusions); MCM2 (see 1 fusions); CCDC88A (see 3 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TPP1parental protein140.154278.016Peptidase_S8 (PF00082, IPR000209): Subtilase family
Pro-kuma_activ (PF09286, IPR015366, SM00944): Pro-kumamolisin, activation domain
2 PRAF2parental protein110.036268.508PRA1 (PF03208, IPR004895): PRA1 family protein
3 ABCE1interactor60.30068.024ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
4 CCDC88Aprotein found in more fusions200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
HOOK (PF05622, IPR008636): HOOK protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
5 CTC1interactor21.0000CTC1 (PF15489, IPR029156): CST, telomere maintenance, complex subunit CTC1
6 DLK1suppressor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
7 DNAJA1interactor40.6673.278DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
8 EGFRoncoprotein60.50046.833Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
9 FAM63Binteractor100DUF544 (PF04424, IPR007518): Protein of unknown function (DUF544)
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
CCDC50_N (PF15295, IPR029311): Coiled-coil domain-containing protein 50 N-terminus
10 FBXO6interactor70.286122.659FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
11 HMOX2interactor30.6670.667Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
12 HNRNPH1oncoprotein50.5008.516RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
13 LPAR1oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
14 MCM2oncoprotein50.5002.833AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
15 NLRP2oncoprotein100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
AAA_16 (PF13191): AAA ATPase domain
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
16 POT1interactor50.33363.000POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
17 RP2interactor2050.841NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
TBCC (PF07986, IPR012945): Tubulin binding cofactor C
18 RTN4suppressor3055.333CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
19 STN1interactor21.0000STN1_2 (PF09170, IPR015253): CST, Suppressor of cdc thirteen homolog, complex subunit STN1
RUN (PF02759, IPR004012, SM00593): RUN domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
Stn1 (PF10451, IPR018856): Telomere regulation protein Stn1
20 TCTN2interactor30.33339.079DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
21 TCTN3interactor30.33339.079DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
22 TERToncoprotein21.0000RVT_1 (PF00078, IPR000477): Reverse transcriptase (RNA-dependent DNA polymerase)
Telomerase_RBD (PF12009, IPR021891, SM00975): Telomerase ribonucleoprotein complex - RNA binding domain
23 TINF2interactor31.0000TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
24 TNFRSF10Bsuppressor2034.333Death (PF00531, IPR000488, SM00005): Death domain
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
25 TSPAN17interactor100Tetraspannin (PF00335, IPR018499): Tetraspanin family
26 TSPAN5interactor100Tetraspannin (PF00335, IPR018499): Tetraspanin family
27 USP7oncoprotein40.6671.000MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal

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