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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CHI3L1, GMDS (from a repository: Sat Aug 3 01:10:49 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins8 (30.77 %)
The number (and %) of the tumor suppressors2 (7.69 %)
Total number of binary PPIs (saturation %)50 (15.38 %)
The number (and %) of affected PPIs25 (50.00 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI3.308
Assortativity coefficient-0.2794
The network average Clustering coefficient0.450
The number (and %) of a zero Clustering coefficients12 (46.15 %)
The number (and %) of a zero Betweenness Centrality18 (69.23 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GMDS,CHI3L1 All fusions
Proteins found in more fusions NF2 (see 1 fusions); GMDS (see 1 fusions); CTH (see 3 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GMDSparental protein220.090370.000GDP_Man_Dehyd (PF16363, IPR016040): GDP-mannose 4,6 dehydratase
2 CHI3L1parental protein306.000Glyco_hydro_18 (PF00704, IPR001223): Glycosyl hydrolases family 18
3 ATIConcoprotein60.8671.000AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
4 BAG3oncoprotein31.0000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
5 BLVRBinteractor100NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
6 BREoncoprotein100BRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
7 CAPN2interactor60.8671.000Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
8 CCDC22interactor100DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
9 CD55oncoprotein200Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
HYLS1_C (PF15311, IPR027918): Hydrolethalus syndrome protein 1 C-terminus
10 CTHprotein found in more fusions60.7003.000Cys_Met_Meta_PP (PF01053, IPR000277): Cys/Met metabolism PLP-dependent enzyme
11 FBXW7suppressor200Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
12 MAT2Binteractor21.0000RmlD_sub_bind (PF04321, IPR005913): RmlD substrate binding domain
13 MTRF1Linteractor100PCRF (PF03462, IPR005139, SM00937): PCRF domain
RF-1 (PF00472, IPR000352): RF-1 domain
14 NDUFA9interactor100Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
15 NF2suppressor31.0000ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
16 NSFL1Cinteractor51.0000SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
17 PSMG4interactor100PAC4 (PF16093, IPR032157): Proteasome assembly chaperone 4
18 PTMAoncoprotein70.7144.000Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
19 RAB2Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
20 RAP1GDS1oncoprotein31.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
WAPL (PF07814, IPR022771): Wings apart-like protein regulation of heterochromatin
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
HEAT_2 (PF13646): HEAT repeats
Nitr_red_bet_C (PF14711, IPR029263): Respiratory nitrate reductase beta C-terminal
SIL1 (PF16782, IPR031884): Nucleotide exchange factor SIL1
21 RNF166interactor30.6671.000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
22 SKA1interactor100SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
23 TATDN1interactor60.8002.000TatD_DNase (PF01026, IPR001130): TatD related DNase
24 TNKSinteractor31.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
25 TTC5interactor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
Abi_C (PF14355, IPR026001): Abortive infection C-terminus
TTC5_OB (PF16669, IPR032076): Tetratricopeptide repeat protein 5 OB fold domain
26 WDYHV1interactor21.0000Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase

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