Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CHI3L1, GMDS (from a repository: Sat Aug 3 01:10:49 2019)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins8 (30.77 %)
The number (and %) of the tumor suppressors2 (7.69 %)
Total number of binary PPIs (saturation %)50 (15.38 %)
The number (and %) of affected PPIs25 (50.00 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI3.308
Assortativity coefficient-0.2794
The network average Clustering coefficient0.450
The number (and %) of a zero Clustering coefficients12 (46.15 %)
The number (and %) of a zero Betweenness Centrality18 (69.23 %)


List of the fusions

PPI for parental proteins: GMDS,CHI3L1 All fusions
Proteins found in more fusions NF2 (see 1 fusions); GMDS (see 1 fusions); CTH (see 3 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 GMDSparental protein220.090370.000GDP_Man_Dehyd (PF16363, IPR016040): GDP-mannose 4,6 dehydratase
2 CHI3L1parental protein306.000Glyco_hydro_18 (PF00704, IPR001223): Glycosyl hydrolases family 18
3 ATIConcoprotein60.8671.000AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
4 BAG3oncoprotein31.0000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
5 BLVRBinteractor100NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
6 BREoncoprotein100BRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
7 CAPN2interactor60.8671.000Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
8 CCDC22interactor100DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
9 CD55oncoprotein200Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
HYLS1_C (PF15311, IPR027918): Hydrolethalus syndrome protein 1 C-terminus
10 CTHprotein found in more fusions60.7003.000Cys_Met_Meta_PP (PF01053, IPR000277): Cys/Met metabolism PLP-dependent enzyme
11 FBXW7suppressor200Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
12 MAT2Binteractor21.0000RmlD_sub_bind (PF04321, IPR005913): RmlD substrate binding domain
13 MTRF1Linteractor100PCRF (PF03462, IPR005139, SM00937): PCRF domain
RF-1 (PF00472, IPR000352): RF-1 domain
14 NDUFA9interactor100Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
15 NF2suppressor31.0000ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
16 NSFL1Cinteractor51.0000SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
17 PSMG4interactor100PAC4 (PF16093, IPR032157): Proteasome assembly chaperone 4
18 PTMAoncoprotein70.7144.000Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
19 RAB2Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
20 RAP1GDS1oncoprotein31.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
WAPL (PF07814, IPR022771): Wings apart-like protein regulation of heterochromatin
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
HEAT_2 (PF13646): HEAT repeats
Nitr_red_bet_C (PF14711, IPR029263): Respiratory nitrate reductase beta C-terminal
SIL1 (PF16782, IPR031884): Nucleotide exchange factor SIL1
21 RNF166interactor30.6671.000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
22 SKA1interactor100SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
23 TATDN1interactor60.8002.000TatD_DNase (PF01026, IPR001130): TatD related DNase
24 TNKSinteractor31.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
25 TTC5interactor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
Abi_C (PF14355, IPR026001): Abortive infection C-terminus
TTC5_OB (PF16669, IPR032076): Tetratricopeptide repeat protein 5 OB fold domain
26 WDYHV1interactor21.0000Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase

B a c k    t o    T o p ⇑