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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CHI3L1, ESYT1 (from a repository: Thu Feb 16 04:14:47 2017)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins8 (21.05 %)
The number (and %) of the tumor suppressors4 (10.53 %)
Total number of binary PPIs (saturation %)93 (13.23 %)
The number (and %) of affected PPIs36 (38.71 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI4.316
Assortativity coefficient-0.2680
The network average Clustering coefficient0.518
The number (and %) of a zero Clustering coefficients11 (28.95 %)
The number (and %) of a zero Betweenness Centrality17 (44.74 %)


List of the fusions

PPI for parental proteins: ESYT1,CHI3L1 All fusions
Proteins found in more fusions RPA1 (see 1 fusions); U2AF2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ESYT1parental protein330.0851135.167C2 (PF00168, IPR000008, SM00239): C2 domain
SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain
2 CHI3L1parental protein30142.000Glyco_hydro_18 (PF00704, IPR001223): Glycosyl hydrolases family 18
3 ARL6IP5suppressor60.5336.333PRA1 (PF03208, IPR004895): PRA1 family protein
RBD-FIP (PF09457, IPR019018): FIP domain
4 ATL3interactor21.0000GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
5 BREoncoprotein100BRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
6 BTN2A1interactor100SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3169 (PF11368, IPR021509): Protein of unknown function (DUF3169)
DUF3213 (PF11491, IPR021583): Protein of unknown function (DUF3213)
Ig_3 (PF13927): Immunoglobulin domain
7 CD55oncoprotein30204.000Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
HYLS1_C (PF15311, IPR027918): Hydrolethalus syndrome protein 1 C-terminus
8 CDK2suppressor51.0000Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
9 CFTRsuppressor40.6671.000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
10 DERL1interactor100.41718.167DER1 (PF04511, IPR007599): Der1-like family
11 DERL2interactor60.6673.167DER1 (PF04511, IPR007599): Der1-like family
12 EDEM1interactor31.0000Glyco_hydro_47 (PF01532, IPR001382): Glycosyl hydrolase family 47
13 ESYT2interactor60.4008.500C2 (PF00168, IPR000008, SM00239): C2 domain
DUF3720 (PF12517, IPR022195): Protein of unknown function (DUF3720)
SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain
14 EVC2interactor100HBS1_N (PF08938, IPR015033): HBS1 N-terminus
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Histone_HNS (PF00816, IPR001801): H-NS histone family
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
15 FAF2interactor60.6003.000DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
16 FN1oncoprotein60.6004.667fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
17 FOXL1oncoprotein100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
18 ITGA4interactor50.8330.667FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
19 MDM2oncoprotein31.0000Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
20 MTRF1Linteractor100PCRF (PF03462, IPR005139, SM00937): PCRF domain
RF-1 (PF00472, IPR000352): RF-1 domain
21 MYH10interactor90.50014.333IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
22 NTRK1oncoprotein90.35717.333I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
23 NUP35interactor21.0000Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif
24 RHOUinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
25 RPA1suppressor80.6674.333Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
26 RPA2oncoprotein50.9000.500RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
27 RPA3interactor51.0000Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
28 SCGNinteractor100EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_10 (PF14788): EF hand
29 SFXN3interactor30.6671.000Mtc (PF03820, IPR004686): Tricarboxylate carrier
30 SYNJ2BPinteractor20264.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
31 TCTN2interactor30.6670.500DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
32 TCTN3interactor50.8001.333DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
33 TMEM17interactor21.0000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
34 TMEM216interactor30.6671.000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
35 TREML2interactor100Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
36 U2AF2protein found in more fusions40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
37 VCAM1interactor31.0000C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
38 YIF1Binteractor31.0000YIF1 (PF03878, IPR005578): YIF1

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