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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FXN, RABL2A (from a repository: Wed Aug 21 00:26:26 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins4 (17.39 %)
The number (and %) of the tumor suppressors3 (13.04 %)
Total number of binary PPIs (saturation %)27 (10.67 %)
The number (and %) of affected PPIs21 (77.78 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI2.000
Assortativity coefficient-0.5692
The network average Clustering coefficient0.181
The number (and %) of a zero Clustering coefficients17 (73.91 %)
The number (and %) of a zero Betweenness Centrality21 (91.30 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FXN,RABL2A All fusions
Proteins found in more fusions ACTN1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FXNparental protein40.16710.000Frataxin_Cyay (PF01491, IPR002908): Frataxin-like domain
2 RABL2Aparental protein170.007270.000Ras (PF00071, IPR001806, SM00173): Ras family
MMR_HSR1_Xtn (PF16897, IPR031662): C-terminal region of MMR_HSR1 domain
3 ACTN1protein found in more fusions200CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
4 AKAP11interactor100E_raikovi_mat (PF06360, IPR009064): Euplotes raikovi mating pheromone
RNA_lig_T4_1 (PF09511, IPR019039): RNA ligase
5 ALMS1interactor100PAD_M (PF08527, IPR013733): Protein-arginine deiminase (PAD) middle domain
Preseq_ALAS (PF09029, IPR015118): 5-aminolevulinate synthase presequence
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
DUF4193 (PF13834, IPR025242): Domain of unknown function (DUF4193)
ALMS_motif (PF15309, IPR029299): ALMS motif
6 BRCA2suppressor100BRCA-2_helical (PF09169, IPR015252): BRCA2, helical
BRCA-2_OB1 (PF09103, IPR015187): BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
BRCA2 (PF00634, IPR002093): BRCA2 repeat
Tower (PF09121, IPR015205): Tower
7 CCDC34interactor100DUF4207 (PF13904): Domain of unknown function (DUF4207)
8 CEP19interactor100CEP19 (PF14933, IPR029412): CEP19-like protein
9 ELAVL1oncoprotein200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 LYRM4interactor31.0000Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
11 MTO1interactor100GIDA (PF01134, IPR002218): Glucose inhibited division protein A
GIDA_assoc (PF13932, IPR026904): GidA associated domain
12 PICK1oncoprotein100Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
13 PMPCBinteractor21.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
14 POLA1interactor100DNA_pol_B (PF00136, IPR006134): DNA polymerase family B
DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain
zf-DNA_Pol (PF08996, IPR015088): DNA Polymerase alpha zinc finger
DNA_pol_alpha_N (PF12254, IPR024647): DNA polymerase alpha subunit p180 N terminal
15 RPP25interactor100Alba (PF01918, IPR002775): Alba
16 SLKinteractor100Pepsin-I3 (PF06394, IPR010480): Pepsin inhibitor-3-like repeated domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TMPIT (PF07851, IPR012926): TMPIT-like protein
TrbI_Ftype (PF09677, IPR014115): Type-F conjugative transfer system protein (TrbI_Ftype)
PKK (PF12474, IPR022165): Polo kinase kinase
17 SMC5interactor100BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
Vac_Fusion (PF02346, IPR003436): Chordopoxvirus multifunctional envelope protein A27
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
AAA_23 (PF13476): AAA domain
YqjK (PF13997, IPR025612): YqjK-like protein
Cache_3-Cache_2 (PF17201): Cache 3/Cache 2 fusion domain
18 SPTAN1oncoprotein21.0000EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
19 SPTBN1suppressor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Spectrin (PF00435, IPR002017): Spectrin repeat
PH_9 (PF15410): Pleckstrin homology domain
20 TBC1D9Binteractor100GRAM (PF02893, IPR004182, SM00568): GRAM domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
21 TP73suppressor200P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
22 TTF2interactor100SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
zf-GRF (PF06839, IPR010666): GRF zinc finger
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
23 VPS13Ainteractor100ATG_C (PF09333, IPR015412): Autophagy-related protein C terminal domain
SHR-BD (PF06650, IPR009543): SHR-binding domain of vacuolar-sorting associated protein 13
DUF1493 (PF07377, IPR010862): Protein of unknown function (DUF1493)
Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
VPS13_C (PF16909, IPR031645): Vacuolar-sorting-associated 13 protein C-terminal
VPS13_mid_rpt (PF16910, IPR031642): Repeating coiled region of VPS13

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