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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LAMP1, BTN2A1 (from a repository: Thu Apr 27 23:21:57 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)57
The number (and %) of the onco-proteins8 (14.04 %)
The number (and %) of the tumor suppressors4 (7.02 %)
Total number of binary PPIs (saturation %)100 (6.27 %)
The number (and %) of affected PPIs55 (55.00 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI3.123
Assortativity coefficient-0.5308
The network average Clustering coefficient0.307
The number (and %) of a zero Clustering coefficients33 (57.89 %)
The number (and %) of a zero Betweenness Centrality36 (63.16 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: BTN2A1,LAMP1 All fusions
Proteins found in more fusions PLCB1 (see 1 fusions); LGALS3 (see 2 fusions); EWSR1 (see 2 fusions); EPAS1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BTN2A1parental protein320.0062099.395SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3169 (PF11368, IPR021509): Protein of unknown function (DUF3169)
DUF3213 (PF11491, IPR021583): Protein of unknown function (DUF3213)
Ig_3 (PF13927): Immunoglobulin domain
2 LAMP1parental protein230.0831159.561Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
3 AIPsuppressor100FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
4 ALG2interactor200Glycos_transf_1 (PF00534, IPR001296): Glycosyl transferases group 1
Glyco_transf_4 (PF13439, IPR028098): Glycosyltransferase Family 4
5 ATP13A2interactor2094.521E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
MARVEL (PF01284, IPR008253): Membrane-associating domain
P5-ATPase (PF12409, IPR006544): P5-type ATPase cation transporter
6 ATP2A3interactor100Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
7 ATP6V1B1interactor21.0000ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
8 BLZF1interactor20114.566DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF1178 (PF06676, IPR009562): Protein of unknown function (DUF1178)
ZapB (PF06005, IPR009252): Cell division protein ZapB
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
9 BTN2A2interactor21.0000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
10 DAGLBinteractor100Lipase_3 (PF01764, IPR002921): Lipase (class 3)
11 DENND6Ainteractor100SPA (PF08616): Stabilization of polarity axis
Avl9 (PF09794, IPR018307): Transport protein Avl9
12 DIP2Ainteractor100AMP-binding (PF00501, IPR000873): AMP-binding enzyme
Cornifin (PF02389, IPR003302): Cornifin (SPRR) family
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
13 ELAVL1oncoprotein140.128734.057RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
14 EPAS1suppressor41.0000Corona_I (PF03187, IPR004876): Corona nucleocapsid I protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
PAS_11 (PF14598): PAS domain
15 ESYT1interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain
16 EWSR1oncoprotein80.333273.164RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
17 FAM171A2interactor100UPF0560 (PF10577, IPR018890): Uncharacterised protein family UPF0560
PRIMA1 (PF16101): Proline-rich membrane anchor 1
18 FAM189Binteractor21.0000CD20 (PF04103, IPR007237): CD20-like family
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
19 FBXO6interactor50.600175.842FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
20 FMN2interactor21.0000ATP-synt_B (PF00430, IPR002146): ATP synthase B/B' CF(0)
DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
AAA_23 (PF13476): AAA domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
21 HLA-DPA1interactor20109.188MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
22 HMGCRoncoprotein100HMG-CoA_red (PF00368, IPR002202): Hydroxymethylglutaryl-coenzyme A reductase
Sterol-sensing (PF12349, IPR000731): Sterol-sensing domain of SREBP cleavage-activation
23 HNRNPA1interactor70.66718.019RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
24 HSD17B10interactor100adh_short (PF00106, IPR002198): short chain dehydrogenase
25 ILF2interactor70.52438.429DZF (PF07528, IPR006561, SM00572): DZF domain
26 ILF3oncoprotein50.8005.429dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
27 ITFG2interactor21.0000BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
Itfg2 (PF15907, IPR031793): Integrin-alpha FG-GAP repeat-containing protein 2
28 KPTNinteractor30.6671.000AcetylCoA_hyd_C (PF13336, IPR026888): Acetyl-CoA hydrolase/transferase C-terminal domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
29 LAPTM5oncoprotein21.0000Mtp (PF03821, IPR004687): Golgi 4-transmembrane spanning transporter
30 LGALS3oncoprotein200Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
31 MARCH7interactor200RINGv (PF12906, IPR011016, SM00744): RING-variant domain
32 ND1interactor100NA
33 NOTCH1suppressor200Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
34 OCRLinteractor20108.597Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
OCRL_clath_bd (PF16726, IPR031995): Inositol polyphosphate 5-phosphatase clathrin binding domain
35 OSBPinteractor20108.597Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH (PF00169, IPR001849, SM00233): PH domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
36 OSGEPinteractor31.0000Peptidase_M22 (PF00814, IPR000905): Glycoprotease family
37 PDZD8interactor20108.597IncA (PF04156, IPR007285): IncA protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
38 PIK3R3interactor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
39 PLCB1oncoprotein200DUF1154 (PF06631, IPR009535): Protein of unknown function (DUF1154)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
PLC-beta_C (PF08703, IPR014815): PLC-beta C terminal
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
zf-C2H2_assoc (PF16606): Unstructured conserved, between two C2H2-type zinc-fingers
40 PLEKHG4interactor100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
HET-s_218-289 (PF11558, IPR021084): Het-s 218-289
PH_10 (PF15411): Pleckstrin homology domain
41 PORinteractor20114.566FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
42 POTEFoncoprotein100Actin (PF00022, IPR004000, SM00268): Actin
Toxin_16 (PF07945, IPR012499): Janus-atracotoxin
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CCDC144C (PF14915): CCDC144C protein coiled-coil region
43 PTP4A1interactor21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
ALS_ss_C (PF10369, IPR019455): Small subunit of acetolactate synthase
44 RAB3GAP1interactor100Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Rab3-GTPase_cat (PF13890, IPR026147): Rab3 GTPase-activating protein catalytic subunit
45 SDAD1interactor21.0000DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
NUC130_3NT (PF08158, IPR012977): NUC130/3NT domain
SDA1 (PF05285, IPR007949): SDA1
YL1 (PF05764, IPR008895): YL1 nuclear protein
46 SGPL1interactor30.333213.451Pyridoxal_deC (PF00282, IPR002129): Pyridoxal-dependent decarboxylase conserved domain
47 SLC25A14interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
48 SLC25A30interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
49 SVIPinteractor21.0000SVIP (PF15811, IPR031632): Small VCP/p97-interacting protein
50 TM9SF4interactor30.66767.521EMP70 (PF02990, IPR004240): Endomembrane protein 70
DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)
51 TMEM214interactor20187.237TMEM214 (PF10151, IPR019308): TMEM214, C-terminal, caspase 4 activator
52 TMX4interactor100DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Thioredoxin (PF00085, IPR013766): Thioredoxin
53 TNFAIP3suppressor40.66721.667OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
54 TYW1interactor20108.597Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
Radical_SAM (PF04055, IPR007197): Radical SAM superfamily
Wyosine_form (PF08608, IPR013917): Wyosine base formation
55 UBL4Ainteractor31.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
56 UPK3BLinteractor100PsbH (PF00737, IPR001056): Photosystem II 10 kDa phosphoprotein
57 ZFPL1interactor100zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF35_N (PF12172, IPR022002): Rubredoxin-like zinc ribbon domain (DUF35_N)
PHD_4 (PF16866, IPR019787): PHD-finger
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type

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