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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins BTN3A2, PRSS23 (from a repository: Wed Feb 26 13:25:27 2020)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins9 (23.08 %)
The number (and %) of the tumor suppressors1 (2.56 %)
Total number of binary PPIs (saturation %)67 (9.04 %)
The number (and %) of affected PPIs37 (55.22 %)
The number of possible different fusions7
PPI diameter2
PPI radiusinf
The average degree of PPI2.769
Assortativity coefficient-0.3466
The network average Clustering coefficient0.374
The number (and %) of a zero Clustering coefficients21 (53.85 %)
The number (and %) of a zero Betweenness Centrality32 (82.05 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: BTN3A2,PRSS23 All fusions
Proteins found in more fusions TCF12 (see 2 fusions); ACTG1 (see 4 fusions); ACTG1/ACTB (see 1 fusions); APP (see 4 fusions); ACTB (see 3 fusions); B2M (see 10 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BTN3A2parental protein4012.000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
MHC2-interact (PF09307, IPR015386): CLIP, MHC2 interacting
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
2 PRSS23parental protein330.032977.000Trypsin (PF00089, IPR001254, SM00020): Trypsin
3 ACTBoncoprotein40.6671.000Actin (PF00022, IPR004000, SM00268): Actin
4 ACTG1protein found in more fusions31.0000Actin (PF00022, IPR004000, SM00268): Actin
5 APPprotein found in more fusions100.25027.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ATP5G1interactor100ATP-synt_C (PF00137, IPR002379): ATP synthase subunit C
7 B2Moncoprotein200C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
8 BAXsuppressor31.0000Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
9 BTN3A1interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
10 BTN3A3interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
11 CHP1interactor21.0000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
12 CTR9interactor100DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
Pap_E4 (PF02711, IPR003861): E4 protein
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175)
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
13 EFNA3interactor100Ephrin (PF00812, IPR001799): Ephrin
Epiglycanin_C (PF14654, IPR028199): Mucin, catalytic, TM and cytoplasmic tail region
14 ELAVL1oncoprotein80.28615.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
15 FAM46Ainteractor21.0000NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
16 FXR1interactor31.0000Agenet (PF05641, IPR008395, SM00743): Agenet domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
FXR_C3 (PF16097, IPR032177): Fragile X-related 1 protein C-terminal region 3
17 GRK6interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
18 HSPA4interactor30.6671.000Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
19 LRP2oncoprotein31.0000Arylesterase (PF01731, IPR002640): Arylesterase
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Form-deh_trans (PF09163, IPR015246): Formate dehydrogenase N, transmembrane
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
20 MAPK8IP2interactor41.0000BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
21 NCAPD3interactor100DUF3013 (PF11217, IPR021380): Protein of unknown function (DUF3013)
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
22 NIPBLoncoprotein100DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Zip (PF02535, IPR003689): ZIP Zinc transporter
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
Cohesin_HEAT (PF12765, IPR026003): HEAT repeat associated with sister chromatid cohesion
Nipped-B_C (PF12830, IPR024986): Sister chromatid cohesion C-terminus
HEAT_2 (PF13646): HEAT repeats
DNA_repr_REX1B (PF14966): DNA repair REX1-B
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
T3SS_basalb_I (PF17001, IPR012670): Type III secretion basal body protein I, YscI, HrpB, PscI
23 NOC4Linteractor100CBF (PF03914, IPR005612, SM00521): CBF/Mak21 family
24 NOP9interactor100PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
25 ODF2Linteractor21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
RNA_bind_2 (PF10133, IPR019300): Predicted RNA-binding protein
SOGA (PF11365, IPR027881): Protein SOGA
DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107)
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
26 PDDC1interactor21.0000DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
27 PDPK1interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
PH_3 (PF14593): PH domain
28 PEX13interactor200Peroxin-13_N (PF04088, IPR007223): Peroxin 13, N-terminal region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
29 PHF23interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
30 PPIAinteractor30.6671.000Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
31 RACGAP1interactor100RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
32 RECQL4oncoprotein100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Drc1-Sld2 (PF11719, IPR021110): DNA replication and checkpoint protein
33 RPL4P5interactor100NA
34 SHMT1interactor200SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
35 SLC25A6interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
36 SRPRAinteractor100SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
SRP54 (PF00448, IPR000897, SM00962): SRP54-type protein, GTPase domain
SRP54_N (PF02881, IPR013822, SM00963): SRP54-type protein, helical bundle domain
37 TCF12oncoprotein31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
38 TMEM222interactor100DUF778 (PF05608, IPR008496): Protein of unknown function (DUF778)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
39 TRAPPC4interactor31.0000Sybindin (PF04099, IPR007233): Sybindin-like family

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