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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PTPN21, PIGK (from a repository: Thu Aug 8 22:57:17 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins2 (11.11 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)41 (26.80 %)
The number (and %) of affected PPIs16 (39.02 %)
The number of possible different fusions1
PPI diameter2
PPI radiusinf
The average degree of PPI4.444
Assortativity coefficient-0.0457
The network average Clustering coefficient0.658
The number (and %) of a zero Clustering coefficients3 (16.67 %)
The number (and %) of a zero Betweenness Centrality10 (55.56 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PIGK,PTPN21 All fusions
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PIGKparental protein120.34860.567Peptidase_C13 (PF01650, IPR001096): Peptidase C13 family
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
2 PTPN21parental protein40.16710.000FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PRIMA1 (PF16101): Proline-rich membrane anchor 1
3 ALPPinteractor21.0000Alk_phosphatase (PF00245, IPR001952, SM00098): Alkaline phosphatase
4 B3GNT3interactor21.0000Galactosyl_T (PF01762, IPR002659): Galactosyltransferase
5 BMXinteractor21.0000BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PH_8 (PF15409): Pleckstrin homology domain
6 CANXinteractor31.0000Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
7 FBXO6interactor50.6003.667FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
8 GPAA1interactor70.8101.900Gaa1 (PF04114, IPR007246): Gaa1-like, GPI transamidase component
YlaH (PF14036, IPR025620): YlaH-like protein
9 KIF1Cinteractor100FHA (PF00498, IPR000253, SM00240): FHA domain
IncA (PF04156, IPR007285): IncA protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
10 LYPD3oncoprotein41.0000DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753)
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
11 PARD6Binteractor100PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
12 PIGSinteractor80.6795.900PIG-S (PF10510, IPR019540): Phosphatidylinositol-glycan biosynthesis class S protein
13 PIGTinteractor60.9330.400Gpi16 (PF04113, IPR007245): Gpi16 subunit, GPI transamidase component
14 PIGUinteractor80.6437.900PIG-U (PF06728, IPR009600): GPI transamidase subunit PIG-U
15 PRSS50interactor51.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
16 SRConcoprotein31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
17 TCTN3interactor70.6675.667DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
18 ULBP2interactor100MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2

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