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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)182
The number (and %) of the onco-proteins62 (34.07 %)
The number (and %) of the tumor suppressors27 (14.84 %)
Total number of binary PPIs (saturation %)1307 (7.94 %)
The number (and %) of affected PPIs184 (14.08 %)
The number of possible different fusions41
PPI diameter4
PPI radius2
The average degree of PPI13.385
Assortativity coefficient-0.2483
The network average Clustering coefficient0.456
The number (and %) of a zero Clustering coefficients10 (5.49 %)
The number (and %) of a zero Betweenness Centrality21 (11.54 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PTPRF,CHD3 All fusions
Proteins found in more fusions CTBP1 (see 2 fusions); MAPK1 (see 1 fusions); GSK3B (see 1 fusions); CUL7 (see 2 fusions); HSF1 (see 3 fusions); BCL6 (see 2 fusions); IVNS1ABP (see 2 fusions); UBA3 (see 1 fusions); IKZF1 (see 1 fusions); AIMP2 (see 1 fusions); IMMT (see 4 fusions); CTTN (see 1 fusions); HTT (see 1 fusions); TSC22D1 (see 5 fusions); UBC (see 1 fusions); DDX5 (see 1 fusions); PRPF40A (see 2 fusions); TP53 (see 3 fusions); SNW1 (see 1 fusions); SAT1 (see 5 fusions); LUC7L2 (see 2 fusions); PUF60 (see 2 fusions); TRIM28 (see 1 fusions); KPNB1 (see 2 fusions); CREB1 (see 2 fusions); SERBP1 (see 1 fusions); PPFIA1 (see 2 fusions); KMT2A (see 16 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); NID1 (see 1 fusions); KDM1A (see 2 fusions); CSNK2A1 (see 1 fusions); CHD3 (see 1 fusions); PFKM (see 1 fusions); MBD2 (see 1 fusions); PTPRF/EGFR (see 1 fusions); UROD (see 1 fusions); TNNT1 (see 1 fusions); CHD4 (see 6 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PTPRFparental protein380.0852259.480Arylsulfotrans (PF05935, IPR010262): Arylsulfotransferase (ASST)
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377)
2 CHD3parental protein1460.07515462.325CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
FAM176 (PF14851): FAM176 family
3 ABCE1interactor150.264134.624ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
4 ADH5interactor51.0000ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
5 AIMP2suppressor90.39312.170GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
AIMP2_LysRS_bd (PF16780, IPR031889): AIMP2 lysyl-tRNA synthetase binding domain
6 ARPC3interactor40.33310.905P21-Arc (PF04062, IPR007204): ARP2/3 complex ARPC3 (21 kDa) subunit
7 ATPIF1interactor30.3337.115DivIC (PF04977, IPR007060): Septum formation initiator
IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
8 BARD1suppressor200.234176.779BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
9 BCL6oncoprotein120.56412.597BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
10 BHLHE40interactor100.500211.916Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
11 BMI1oncoprotein200.28175.312zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
12 C4orf17interactor21.0000SPATIAL (PF15256): SPATIAL
13 CASP6interactor40.6671.000Peptidase_C14 (PF00656, IPR011600): Caspase domain
14 CASP8suppressor80.38126.200DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
15 CAV1suppressor90.41731.848Caveolin (PF01146, IPR001612): Caveolin
16 CCDC8interactor210.300145.491Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
17 CD2BP2interactor70.5716.370GYF (PF02213, IPR003169, SM00444): GYF domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
18 CDK2AP1suppressor150.9900.111CDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
19 CDKN2AIPinteractor40.16713.209XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
20 CEACAM21interactor30.6672.278V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
21 CHD4oncoprotein400.345325.949CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
FAM176 (PF14851): FAM176 family
Coilin_N (PF15862, IPR031722): Coilin N-terminus
22 CHD6interactor21.0000CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
23 CPEinteractor21.0000Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
CarboxypepD_reg (PF13620): Carboxypeptidase regulatory-like domain
24 CPSF1interactor80.39316.291CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
HPS3_N (PF14761, IPR029437): Hermansky-Pudlak syndrome 3
25 CRCT1interactor40.6670.704NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
26 CREB1oncoprotein170.45036.552bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
27 CSNK2A1oncoprotein280.302155.463Pkinase (PF00069, IPR000719): Protein kinase domain
28 CSTF2interactor60.5335.168RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
CSTF_C (PF14304, IPR026896): Transcription termination and cleavage factor C-terminal
CSTF2_hinge (PF14327, IPR025742): Hinge domain of cleavage stimulation factor subunit 2
29 CTBP1protein found in more fusions190.37382.5252-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
30 CTNNB1oncoprotein270.154491.840Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
31 CTTNoncoprotein90.35782.620FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
32 CUL7protein found in more fusions350.143579.562ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
33 DDX5oncoprotein220.300116.072DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
P68HR (PF08061, IPR012587): P68HR (NUC004) repeat
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
34 DNAAF5interactor100.31153.765HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
35 EGFRoncoprotein210.184233.343Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
36 ENO1oncoprotein140.30883.303Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
37 FABP4interactor21.0000Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
38 FAM134Ainteractor100INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
Reticulon (PF02453, IPR003388): Reticulon
39 FBP2interactor200FBPase (PF00316, IPR000146): Fructose-1-6-bisphosphatase, N-terminal domain
40 FUBP1oncoprotein100.44416.699DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
41 GADD45Asuppressor70.53310.849Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
42 GATAD2Ainteractor180.8765.694DUF2299 (PF10061, IPR018747): Uncharacterized conserved protein (DUF2299)
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
P66_CC (PF16563, IPR032346): Coiled-coil and interaction region of P66A and P66B with MBD2
43 GATAD2Binteractor220.69738.940DUF1178 (PF06676, IPR009562): Protein of unknown function (DUF1178)
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
DUF3619 (PF12279, IPR022064): Protein of unknown function (DUF3619)
P66_CC (PF16563, IPR032346): Coiled-coil and interaction region of P66A and P66B with MBD2
44 GIT1interactor160.181512.015ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
FlxA (PF14282, IPR025577): FlxA-like protein
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
45 GPS2oncoprotein80.393136.196G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
46 GRK2interactor60.40015.337ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
47 GSK3Bsuppressor130.30394.357Pkinase (PF00069, IPR000719): Protein kinase domain
48 HABP4interactor40.8330.143HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
49 HACL1interactor200TPP_enzyme_C (PF02775, IPR011766): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
TPP_enzyme_N (PF02776, IPR012001): Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
50 HDAC1suppressor540.285624.761FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
51 HDAC2suppressor520.305513.099Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
52 HDAC3suppressor150.30829.710Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
53 HEPACAM2interactor202.278V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
PgaD (PF13994, IPR023829): PgaD-like protein
54 HIC1suppressor90.5363.680BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
55 HIST1H2BBinteractor50.6002.288Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
56 HIST1H3Ainteractor240.336203.357Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
57 HSD17B10interactor80.35781.476adh_short (PF00106, IPR002198): short chain dehydrogenase
58 HSF1protein found in more fusions80.61911.654DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
59 HSPH1oncoprotein30.6671.247HSP70 (PF00012, IPR013126): Hsp70 protein
SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain
60 HTTprotein found in more fusions110.40024.631HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
61 IKinteractor100.5838.455Lsm_interact (PF05391, IPR008669): Lsm interaction motif
RED_C (PF07807, IPR012492): RED-like protein C-terminal region
RED_N (PF07808, IPR012916): RED-like protein N-terminal region
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
62 IKZF1suppressor120.6555.280Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
63 IMMTprotein found in more fusions160.200100.325Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
64 IVNS1ABPprotein found in more fusions60.5002.048BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
65 JUNoncoprotein180.33162.035bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
66 JUPsuppressor80.53613.134Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
67 KDM1Aprotein found in more fusions340.341295.485Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
68 KDM5Binteractor110.8731.784ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
JmjN (PF02375, IPR003349, SM00545): jmjN domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PLU-1 (PF08429, IPR013637): PLU-1-like protein
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Rubredoxin (PF00301, IPR024935): Rubredoxin
zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger
Lipoprotein_20 (PF13942, IPR025262): YfhG lipoprotein
69 KIF15interactor30.6671.247Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
STE (PF02200, IPR003120, SM00424): STE like transcription factor
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
FlxA (PF14282, IPR025577): FlxA-like protein
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
70 KMT2Aoncoprotein200.48051.320AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus
FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SET (PF00856, IPR001214, SM00317): SET domain
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
71 KPNB1protein found in more fusions180.35375.868Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
72 LGR4interactor90.3219.2697tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
73 LRIF1interactor140.25676.006LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
74 LUC7L2protein found in more fusions180.26592.039LUC7 (PF03194, IPR004882): LUC7 N_terminus
Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein
Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
75 MAFGoncoprotein31.0000bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
ThrE_2 (PF12821, IPR024528): Threonine/Serine exporter, ThrE
76 MAN2A2interactor40.5001.714Alpha-mann_mid (PF09261, IPR015341, SM00872): Alpha mannosidase middle domain
Glyco_hydro_38 (PF01074, IPR000602): Glycosyl hydrolases family 38 N-terminal domain
Glyco_hydro_38C (PF07748, IPR011682): Glycosyl hydrolases family 38 C-terminal domain
77 MAPK1oncoprotein180.169211.173Pkinase (PF00069, IPR000719): Protein kinase domain
78 MBD2oncoprotein200.8257.109API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
MBD_C (PF14048, IPR025884): C-terminal domain of methyl-CpG binding protein 2 and 3
MBDa (PF16564, IPR032343): p55-binding region of Methyl-CpG-binding domain proteins MBD
79 MBD3interactor300.51073.532DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
80 MBD3L1interactor160.9500.938MBD_C (PF14048, IPR025884): C-terminal domain of methyl-CpG binding protein 2 and 3
MBDa (PF16564, IPR032343): p55-binding region of Methyl-CpG-binding domain proteins MBD
81 MCM2oncoprotein280.202310.545AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
82 METAP2oncoprotein30.33314.451Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
83 MOV10interactor250.190464.381AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
84 MTA1oncoprotein320.454187.675BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
85 MTA2interactor330.456178.907BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain
DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
86 MTA3oncoprotein220.68030.873BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
87 MX1interactor41.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
88 MYBoncoprotein80.5364.962Cmyb_C (PF09316, IPR015395): C-myb, C-terminal
LMSTEN (PF07988, IPR012642): LMSTEN motif
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
89 NAA50interactor2012.983Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
90 NAB2oncoprotein31.0000NCD1 (PF04904, IPR006988): NAB conserved region 1 (NCD1)
NCD2 (PF04905, IPR006989): NAB conserved region 2 (NCD2)
91 NEFLinteractor50.5001.437Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
NOA36 (PF06524, IPR010531): NOA36 protein
BORG_CEP (PF14957, IPR029273): Cdc42 effector
92 NID1protein found in more fusions31.0000EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
G2F (PF07474, IPR006605, SM00682): G2F domain
NIDO (PF06119, IPR003886, SM00539): Nidogen-like
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
93 NPLOC4interactor100.42237.084NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
94 NR1H2oncoprotein50.6000.829zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
95 NR4A1suppressor60.5334.166zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
96 NTRK1oncoprotein670.1002947.179I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
97 NXF1interactor250.174288.614NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
98 OTUD6Binteractor21.0000Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
HemY_N (PF07219, IPR010817): HemY protein N-terminus
OTU (PF02338, IPR003323): OTU-like cysteine protease
DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
99 PAICSinteractor50.3339.089AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
100 PCMT1interactor80.5717.105PCMT (PF01135, IPR000682): Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
101 PCNTinteractor70.6678.231Caldesmon (PF02029, IPR006018): Caldesmon
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1640 (PF07798, IPR024461): Protein of unknown function (DUF1640)
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
SlyX (PF04102, IPR007236): SlyX
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
PACT_coil_coil (PF10495, IPR019528): Pericentrin-AKAP-450 domain of centrosomal targeting protein
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Colicin-DNase (PF12639, IPR024622): DNase/tRNase domain of colicin-like bacteriocin
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
DUF4239 (PF14023, IPR025333): Protein of unknown function (DUF4239)
WD40_alt (PF14077, IPR026987): Alternative WD40 repeat motif
FlxA (PF14282, IPR025577): FlxA-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
102 PFKMprotein found in more fusions100.33335.037PFK (PF00365, IPR000023): Phosphofructokinase
103 PHF20L1interactor130.8335.194MBT (PF02820, IPR004092, SM00561): mbt repeat
PHD (PF00628, IPR019787, SM00249): PHD-finger
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
DUF3776 (PF12618, IPR022255): Protein of unknown function (DUF3776)
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
PEHE (PF15275, IPR029332): PEHE domain
EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
PHD20L1_u1 (PF16660): PHD finger protein 20-like protein 1
104 PHF6suppressor90.50015.045zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
YqfQ (PF14181, IPR025571): YqfQ-like protein
105 PIAS4interactor230.277154.278CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
106 PICALMoncoprotein100.31146.523ANTH (PF07651, IPR011417): ANTH domain
107 PLK4interactor40.6671.000ABC1 (PF03109, IPR004147): ABC1 family
Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
DUF4520 (PF15016, IPR027865): Domain of unknown function (DUF4520)
108 PPFIA1protein found in more fusions100.38975.988HWE_HK (PF07536, IPR011102, SM00911): HWE histidine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Cluap1 (PF10234, IPR019366): Clusterin-associated protein-1
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
TSNAXIP1_N (PF15739, IPR032755): Translin-associated factor X-interacting N-terminus
FAM76 (PF16046, IPR032017): FAM76 protein
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
109 PPFIA2interactor60.8002.784DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
HWE_HK (PF07536, IPR011102, SM00911): HWE histidine kinase
IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SlyX (PF04102, IPR007236): SlyX
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
110 PPFIA3interactor70.60016.195DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
T2SSF (PF00482, IPR018076): Type II secretion system (T2SS), protein F
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
Tup_N (PF08581, IPR013890): Tup N-terminal
FTA4 (PF13093, IPR025207): Kinetochore complex Fta4 of Sim4 subunit, or CENP-50
FAM76 (PF16046, IPR032017): FAM76 protein
111 PPP2R5Dinteractor60.33328.407B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
112 PPWD1interactor30.6676.373DUF505 (PF04458, IPR007548): Protein of unknown function (DUF505)
Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
113 PRG2interactor100Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF4628 (PF15429, IPR027851): Domain of unknown function (DUF4628)
114 PRPF40Aprotein found in more fusions150.407122.172FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
115 PSMD14interactor50.40011.022JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
116 PSME1interactor60.5002.233PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
117 PTNoncoprotein160.190108.391PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
118 PTPRSinteractor100.133604.244fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
Ig_3 (PF13927): Immunoglobulin domain
119 PUF60protein found in more fusions130.37923.074RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Titin_Z (PF09042, IPR015129): Titin Z
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
120 RAD21oncoprotein160.325133.983Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
121 RAD51interactor80.5713.482Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
122 RBBP4oncoprotein370.426194.455eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
123 RBBP7suppressor370.398346.568WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
124 REToncoprotein60.50013.350Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
125 RGS2oncoprotein30.6670.935RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
126 RNF2interactor280.37694.050zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
127 RPL10suppressor140.42926.218Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
128 RPL29interactor50.5003.776BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Ribosomal_L29e (PF01779, IPR002673): Ribosomal L29e protein family
129 RYKoncoprotein110.218137.467Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain
130 SAFBsuppressor90.30633.548RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
131 SAT1protein found in more fusions90.32188.714Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
132 SATB1oncoprotein150.41941.516CUT (PF02376, IPR003350, SM01109): CUT domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371)
ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB
CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
133 SCN2Binteractor100DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
134 SDCCAG3interactor40.5007.141GA (PF01468, IPR002988, SM00844): GA module
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
135 SEPHS1interactor4020.760AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
136 SERBP1protein found in more fusions100.52810.501HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
137 SERF2interactor1004F5 (PF04419, IPR007513): 4F5 protein family
138 SGSM2interactor30.3335.930Cullin_binding (PF03556, IPR005176): Cullin binding
RUN (PF02759, IPR004012, SM00593): RUN domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
DUF3548 (PF12068, IPR021935): Domain of unknown function (DUF3548)
139 SHMT2interactor90.25039.608SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
140 SIN3Aoncoprotein340.364248.484Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
141 SIRT1suppressor200.310106.940DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
142 SIRT6suppressor110.6555.344SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
143 SKILsuppressor90.393271.378c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
144 SLC27A6interactor21.0000AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
145 SMARCA2suppressor150.61917.877DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
BRK (PF07533, IPR006576, SM00592): BRK domain
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
146 SMARCA5interactor250.40988.295HAND (PF09110, IPR015194): HAND
SLIDE (PF09111, IPR015195): SLIDE
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DBINO (PF13892, IPR020838): DNA-binding domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
147 SMARCC2interactor190.40459.232GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
148 SNRNP40interactor60.5334.264WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
149 SNW1protein found in more fusions330.250405.885SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
150 SOX2oncoprotein320.301487.770HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
151 SRRTinteractor110.40027.415ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3546 (PF12066, IPR021933): Domain of unknown function (DUF3546)
DUF4187 (PF13821, IPR025239): Domain of unknown function (DUF4187)
152 SUMO1interactor160.39054.505Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
153 SUMO2interactor200.45681.629Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
154 TAF6interactor120.8038.478CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
Spo0A_C (PF08769, IPR014879): Sporulation initiation factor Spo0A C terminal
TAF (PF02969, IPR004823, SM00803): TATA box binding protein associated factor (TAF)
155 TAL1oncoprotein100.7223.583HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
156 TCERG1interactor70.6196.121FF (PF01846, IPR002713, SM00441): FF domain
WW (PF00397, IPR001202, SM00456): WW domain
Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
FAM150 (PF15129, IPR029364): FAM150 family
157 TGFBR2suppressor40.16712.023ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
158 THOC7interactor60.3334.172EcoEI_R_C (PF08463, IPR013670): EcoEI R protein C-terminal
THOC7 (PF05615, IPR008501): Tho complex subunit 7
UPF0193 (PF05250, IPR007914): Uncharacterised protein family (UPF0193)
159 TNFRSF14oncoprotein30.6670.286Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
160 TNNT1protein found in more fusions70.40033.851Troponin (PF00992, IPR001978): Troponin
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
161 TP53suppressor570.1821167.407DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
162 TP73suppressor110.6228.293P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
163 TRIM28protein found in more fusions230.34688.744ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
164 TRIOoncoprotein21.0000T3SS_needle_E (PF08988, IPR012671): Type III secretion system, cytoplasmic E component of needle
GRP (PF07172, IPR010800): Glycine rich protein family
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pap_E4 (PF02711, IPR003861): E4 protein
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Spectrin (PF00435, IPR002017): Spectrin repeat
CRAL_TRIO (PF00650, IPR001251, SM00516): CRAL/TRIO domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Myb_DNA-bind_4 (PF13837): Myb/SANT-like DNA-binding domain
PH_10 (PF15411): Pleckstrin homology domain
SH3-RhoG_link (PF16609): SH3-RhoGEF linking unstructured region
165 TSC22D1suppressor90.214139.598SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
166 TSPAN6interactor21.0000Tetraspannin (PF00335, IPR018499): Tetraspanin family
167 TSTA3interactor3011.439Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
NICE-3 (PF07406, IPR010876): NICE-3 protein
Polysacc_synt_2 (PF02719, IPR003869): Polysaccharide biosynthesis protein
168 TTRinteractor31.0000Transthyretin (PF00576, IPR023416, SM00095): HIUase/Transthyretin family
169 TWIST1oncoprotein90.6673.958ACC_epsilon (PF13822, IPR032716): Acyl-CoA carboxylase epsilon subunit
PRR20 (PF15708, IPR031439): Proline-rich protein family 20
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
170 TXNDC9interactor40.5002.230Thioredoxin (PF00085, IPR013766): Thioredoxin
DUF3619 (PF12279, IPR022064): Protein of unknown function (DUF3619)
171 UBA3protein found in more fusions31.0000E2_bind (PF08825, IPR014929): E2 binding domain
ThiF (PF00899, IPR000594): ThiF family
172 UBCprotein found in more fusions310.225480.615ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
173 UBE2Iinteractor350.228300.128UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
174 UFD1Linteractor60.53314.000UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
175 UNKinteractor140.121140.232MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
176 URODprotein found in more fusions60.3008.643URO-D (PF01208, IPR000257): Uroporphyrinogen decarboxylase (URO-D)
177 VIMsuppressor470.1041118.349Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
178 XRCC4interactor50.5000.576XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
179 YAE1D1interactor30.6673.299Yae1_N (PF09811, IPR019191): Essential protein Yae1, N terminal
180 ZHX1interactor180.36854.450Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez
zf-C2H2_4 (PF13894): C2H2-type zinc finger
TerB_C (PF15615, IPR028932): TerB-C domain
181 ZNF219interactor160.8924.146Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
182 ZNF512Binteractor70.33345.831YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

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