| 1 |
WWP1 | parental protein | 73 | 0.057 | 3957.490 | C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
| 2 |
ARRDC1 | interactor | 2 | 1.000 | 0 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
| 3 |
ARRDC2 | interactor | 1 | 0 | 0 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
| 4 |
ARRDC3 | interactor | 2 | 1.000 | 0 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
| 5 |
ASH2L | interactor | 2 | 0 | 0 | SPRY (PF00622, IPR003877, SM00449): SPRY domain
PHD20L1_u1 (PF16660): PHD finger protein 20-like protein 1 |
| 6 |
ATN1 | protein found in more fusions | 5 | 0.833 | 0.667 | Atrophin-1 (PF03154, IPR002951): Atrophin-1 family |
| 7 |
CDK8 | interactor | 7 | 0.733 | 3.333 | Pkinase (PF00069, IPR000719): Protein kinase domain |
| 8 |
CPSF6 | interactor | 5 | 0.700 | 2.333 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
| 9 |
DAZAP2 | protein found in more fusions | 4 | 0.667 | 1.000 | DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2) |
| 10 |
DIDO1 | suppressor | 2 | 1.000 | 0 | PHD (PF00628, IPR019787, SM00249): PHD-finger
SlyX (PF04102, IPR007236): SlyX
SPOC (PF07744, IPR012921): SPOC domain
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 |
| 11 |
DVL2 | interactor | 5 | 0.667 | 2.000 | DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal |
| 12 |
ERBB4 | suppressor | 4 | 0.667 | 0.667 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
| 13 |
ESR2 | suppressor | 6 | 0.400 | 5.167 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta |
| 14 |
EWSR1 | oncoprotein | 8 | 0.429 | 10.286 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head |
| 15 |
EZH2 | suppressor | 7 | 0.400 | 8.333 | CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal |
| 16 |
EZR | protein found in more fusions | 2 | 0 | 0 | DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain |
| 17 |
FAM189A2 | interactor | 3 | 1.000 | 0 | CD20 (PF04103, IPR007237): CD20-like family |
| 18 |
FAM189B | interactor | 3 | 1.000 | 0 | CD20 (PF04103, IPR007237): CD20-like family
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family |
| 19 |
FBXL15 | interactor | 3 | 0.667 | 0.667 | LRV (PF01816, IPR004830): Leucine rich repeat variant
F-box (PF00646, IPR001810, SM00256): F-box domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat |
| 20 |
FBXL18 | interactor | 4 | 0.500 | 2.667 | LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
F-box (PF00646, IPR001810, SM00256): F-box domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat |
| 21 |
H2AFY2 | interactor | 2 | 1.000 | 0 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Macro (PF01661, IPR002589, SM00506): Macro domain
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A |
| 22 |
HIVEP3 | suppressor | 3 | 0.667 | 0.667 | Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3 |
| 23 |
HSP90AA1 | oncoprotein | 11 | 0.200 | 34.000 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein |
| 24 |
HSPB1 | oncoprotein | 7 | 0.333 | 8.167 | HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family |
| 25 |
IKBKG | interactor | 7 | 0.467 | 6.786 | CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
| 26 |
ITCH | interactor | 36 | 0.111 | 506.871 | C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
| 27 |
KLF2 | interactor | 1 | 0 | 0 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |
| 28 |
KLF5 | suppressor | 5 | 0.700 | 2.333 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |
| 29 |
LAPTM5 | oncoprotein | 3 | 1.000 | 0 | Mtp (PF03821, IPR004687): Golgi 4-transmembrane spanning transporter |
| 30 |
LATS1 | suppressor | 4 | 0.667 | 1.000 | Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
| 31 |
LDLRAD4 | interactor | 4 | 1.000 | 0 | Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615) |
| 32 |
LITAF | suppressor | 3 | 0.667 | 1.000 | zf-LITAF-like (PF10601, IPR006629, SM00714): LITAF-like zinc ribbon domain
DUF3824 (PF12868, IPR024436): Domain of unknwon function (DUF3824) |
| 33 |
LNX1 | interactor | 5 | 0.500 | 3.000 | PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
| 34 |
LZTR1 | oncoprotein | 3 | 1.000 | 0 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif |
| 35 |
NOTCH1 | suppressor | 5 | 0.667 | 1.333 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) |
| 36 |
PCBD1 | interactor | 4 | 0.667 | 1.000 | Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase |
| 37 |
PHF20L1 | interactor | 2 | 1.000 | 0 | MBT (PF02820, IPR004092, SM00561): mbt repeat
PHD (PF00628, IPR019787, SM00249): PHD-finger
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
DUF3776 (PF12618, IPR022255): Protein of unknown function (DUF3776)
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
PEHE (PF15275, IPR029332): PEHE domain
EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
PHD20L1_u1 (PF16660): PHD finger protein 20-like protein 1 |
| 38 |
PRKAA2 | suppressor | 2 | 1.000 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase |
| 39 |
PTCH1 | suppressor | 2 | 1.000 | 0 | Patched (PF02460, IPR003392): Patched family |
| 40 |
PTEN | suppressor | 8 | 0.393 | 12.667 | DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein |
| 41 |
PTPN14 | oncoprotein | 4 | 0.833 | 0.500 | FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase |
| 42 |
RNF11 | protein found in more fusions | 10 | 0.472 | 14.419 | zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger |
| 43 |
RTN4 | suppressor | 2 | 0 | 0 | CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein |
| 44 |
RUNX2 | suppressor | 7 | 0.571 | 8.667 | DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Runt (PF00853, IPR013524): Runt domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722) |
| 45 |
SCNN1A | interactor | 2 | 1.000 | 0 | ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel |
| 46 |
SETD4 | interactor | 1 | 0 | 0 | Rubis-subs-bind (PF09273, IPR015353): Rubisco LSMT substrate-binding
SET (PF00856, IPR001214, SM00317): SET domain |
| 47 |
SFTPC | protein found in more fusions | 2 | 0 | 0 | BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SP_C-Propep (PF08999, IPR015091): Surfactant protein C, N terminal propeptide |
| 48 |
SKIL | suppressor | 6 | 1.000 | 0 | c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115) |
| 49 |
SMAD1 | interactor | 12 | 0.582 | 12.952 | MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain |
| 50 |
SMAD2 | suppressor | 14 | 0.526 | 19.571 | MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain |
| 51 |
SMAD3 | oncoprotein | 15 | 0.429 | 35.119 | MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain |
| 52 |
SMAD4 | suppressor | 12 | 0.509 | 18.252 | MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain |
| 53 |
SMAD5 | interactor | 8 | 0.786 | 2.486 | MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain |
| 54 |
SMAD6 | interactor | 7 | 0.810 | 1.452 | MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain |
| 55 |
SMAD7 | interactor | 8 | 0.714 | 4.571 | MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain |
| 56 |
SPG20 | interactor | 3 | 1.000 | 0 | MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
Senescence (PF06911, IPR009686): Senescence-associated protein |
| 57 |
STAT6 | oncoprotein | 3 | 0.667 | 1.000 | SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT6_C (PF14596, IPR028187): STAT6 C-terminal |
| 58 |
TMEM255A | interactor | 2 | 1.000 | 0 | FAM70 (PF14967, IPR028014): FAM70 protein |
| 59 |
TMEM255B | interactor | 1 | 0 | 0 | FAM70 (PF14967, IPR028014): FAM70 protein |
| 60 |
TMEM51 | interactor | 2 | 1.000 | 0 | WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
TMEM51 (PF15345, IPR029265): Transmembrane protein 51 |
| 61 |
TP63 | suppressor | 5 | 0.833 | 0.667 | Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) |
| 62 |
TRAF4 | oncoprotein | 4 | 0.667 | 1.000 | MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger |
| 63 |
TRAF6 | protein found in more fusions | 10 | 0.556 | 11.300 | SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
| 64 |
UBC | protein found in more fusions | 19 | 0.255 | 97.752 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
| 65 |
UBE2D1 | interactor | 8 | 0.762 | 2.286 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
| 66 |
UBE2D2 | oncoprotein | 9 | 0.679 | 7.119 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
| 67 |
UBE2D3 | interactor | 6 | 0.900 | 0.286 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
| 68 |
UBE2L3 | interactor | 8 | 0.667 | 4.167 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
| 69 |
WBP1 | interactor | 2 | 1.000 | 0 | WBP-1 (PF11669, IPR021684): WW domain-binding protein 1 |
| 70 |
WBP2 | interactor | 2 | 1.000 | 0 | GRAM (PF02893, IPR004182, SM00568): GRAM domain
Vps36_ESCRT-II (PF11605, IPR021648): Vacuolar protein sorting protein 36 Vps36 |
| 71 |
XRCC5 | suppressor | 5 | 0.500 | 2.667 | Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like |
| 72 |
YWHAQ | interactor | 4 | 0.500 | 2.333 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
| 73 |
ZNF638 | interactor | 2 | 1.000 | 0 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-met (PF12874): Zinc-finger of C2H2 type
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus |