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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins VEPH1, ADRM1 (from a repository: Thu Oct 17 18:20:26 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)62
The number (and %) of the onco-proteins19 (30.65 %)
The number (and %) of the tumor suppressors2 (3.23 %)
Total number of binary PPIs (saturation %)1046 (55.31 %)
The number (and %) of affected PPIs60 (5.74 %)
The number of possible different fusions12
PPI diameter2
PPI radiusinf
The average degree of PPI32.935
Assortativity coefficient-0.1655
The network average Clustering coefficient0.798
The number (and %) of a zero Clustering coefficients3 (4.84 %)
The number (and %) of a zero Betweenness Centrality8 (12.90 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions PSMC2 (see 1 fusions); PSMB3 (see 1 fusions); UBQLN1 (see 2 fusions); PSMB7 (see 2 fusions); PSMA7 (see 2 fusions); UBC (see 1 fusions); APP (see 4 fusions); HUWE1 (see 2 fusions); FKBP8 (see 1 fusions); EGFR (see 2 fusions); PSMC5 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 VEPH1oncoprotein000PH (PF00169, IPR001849, SM00233): PH domain
2 ADRM1parental protein600.543539.557Proteasom_Rpn13 (PF04683, IPR006773): Proteasome complex subunit Rpn13 ubiquitin receptor
GET2 (PF08690, IPR028143): GET complex subunit GET2
RPN13_C (PF16550, IPR032368): UCH-binding domain
3 APPprotein found in more fusions170.56721.991APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ATP6V0D2interactor100vATP-synt_AC39 (PF01992, IPR002843): ATP synthase (C/AC39) subunit
5 BAG1oncoprotein60.9330.065BAG (PF02179, IPR003103, SM00264): BAG domain
Presenilin (PF01080, IPR001108): Presenilin
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
6 BIRC2oncoprotein41.0000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
7 CCDC74Binteractor201.0000CCDC92 (PF14916): Coiled-coil domain of unknown function
CCDC74_C (PF14917, IPR029422): Coiled coil protein 74, C terminal
8 CCDC92interactor171.0000Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
CCDC92 (PF14916): Coiled-coil domain of unknown function
9 EGFRoncoprotein120.6917.182Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
10 FKBP8protein found in more fusions320.9355.861FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
11 HUWE1oncoprotein340.86412.255BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
12 INSIG2interactor150.9141.271INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
13 MX1interactor31.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
14 PAAF1interactor220.9780.363WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
15 PARK2suppressor420.79827.182IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
16 PIPSLinteractor100NA
17 PPP1R2P4interactor41.0000NA
18 PSMA1interactor430.86513.428Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
19 PSMA2interactor450.84714.544Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
20 PSMA3interactor430.86320.008Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
21 PSMA4interactor380.9522.460Proteasome (PF00227, IPR001353): Proteasome subunit
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
22 PSMA5oncoprotein400.89211.106Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
23 PSMA6interactor430.86512.335Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
24 PSMA7protein found in more fusions450.81526.854Proteasome (PF00227, IPR001353): Proteasome subunit
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
25 PSMB1interactor400.9087.091Proteasome (PF00227, IPR001353): Proteasome subunit
26 PSMB2interactor390.9274.566Proteasome (PF00227, IPR001353): Proteasome subunit
27 PSMB3protein found in more fusions390.9305.308Proteasome (PF00227, IPR001353): Proteasome subunit
28 PSMB4interactor380.9226.859Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Proteasome (PF00227, IPR001353): Proteasome subunit
29 PSMB5interactor380.9532.372Proteasome (PF00227, IPR001353): Proteasome subunit
30 PSMB6interactor370.9611.875DUF1502 (PF07397, IPR010871): Repeat of unknown function (DUF1502)
Proteasome (PF00227, IPR001353): Proteasome subunit
31 PSMB7protein found in more fusions410.9185.290Proteasome (PF00227, IPR001353): Proteasome subunit
Pr_beta_C (PF12465, IPR024689): Proteasome beta subunits C terminal
32 PSMB8interactor350.9790.961Proteasome (PF00227, IPR001353): Proteasome subunit
33 PSMC1interactor520.69270.755AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
34 PSMC2protein found in more fusions500.75535.532AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
35 PSMC3interactor480.78428.281AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
36 PSMC4interactor460.81718.748AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
NTPase_1 (PF03266, IPR004948): NTPase
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
AAA_16 (PF13191): AAA ATPase domain
37 PSMC5protein found in more fusions480.79523.920AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
38 PSMC6interactor490.74437.695AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
39 PSMD1interactor500.72259.542PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
HEAT_2 (PF13646): HEAT repeats
40 PSMD10interactor260.9202.566Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
41 PSMD11interactor480.75140.072DUF247 (PF03140, IPR004158): Plant protein of unknown function
PCI (PF01399, IPR000717, SM00088): PCI domain
AAA_16 (PF13191): AAA ATPase domain
TPR_12 (PF13424): Tetratricopeptide repeat
42 PSMD12interactor480.79623.808Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
43 PSMD13interactor480.73062.335Mitovir_RNA_pol (PF05919, IPR008686): Mitovirus RNA-dependent RNA polymerase
PCI (PF01399, IPR000717, SM00088): PCI domain
44 PSMD14interactor500.74040.531JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
45 PSMD2oncoprotein490.71758.257PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
46 PSMD3interactor480.73842.572Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
47 PSMD4interactor500.71953.220UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
48 PSMD6interactor450.81420.391RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
49 PSMD7interactor440.85312.570JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
Auts2 (PF15336): Autism susceptibility gene 2 protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
50 PSMD8interactor450.79725.747CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
51 PSME1interactor270.8894.571PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
52 RAD23Aoncoprotein420.84315.516UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
53 RAD23Bsuppressor230.8186.935K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
54 RPS21interactor140.8242.873Ribosomal_S21e (PF01249, IPR001931): Ribosomal protein S21e
55 RPS8interactor120.9090.695Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
56 SHFM1interactor360.76725.829CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
57 TXNL1interactor230.85811.904PITH (PF06201, IPR010400): PITH domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
58 UBCprotein found in more fusions410.71065.088ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
59 UBE3Aoncoprotein160.8193.165HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
60 UBQLN1protein found in more fusions180.7355.561Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
61 UCHL5oncoprotein490.72164.193Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
62 USP14interactor280.9054.349UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family

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