Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ILVBL, DPP4 (from a repository: Fri Jul 26 08:47:25 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)50
The number (and %) of the onco-proteins16 (32.00 %)
The number (and %) of the tumor suppressors5 (10.00 %)
Total number of binary PPIs (saturation %)180 (14.69 %)
The number (and %) of affected PPIs48 (26.67 %)
The number of possible different fusions11
PPI diameter5
PPI radius3
The average degree of PPI6.480
Assortativity coefficient-0.0994
The network average Clustering coefficient0.490
The number (and %) of a zero Clustering coefficients6 (12.00 %)
The number (and %) of a zero Betweenness Centrality13 (26.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DPP4,ILVBL All fusions
Proteins found in more fusions NDUFS3 (see 2 fusions); ILK (see 2 fusions); HNRNPC (see 1 fusions); IKBKB (see 2 fusions); CUL3 (see 1 fusions); KIF11 (see 1 fusions); ATXN1 (see 3 fusions); EGFR (see 2 fusions); MYC (see 2 fusions); SRSF1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DPP4parental protein70.143375.100DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
2 ILVBLparental protein410.1331327.829TPP_enzyme_C (PF02775, IPR011766): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
TPP_enzyme_N (PF02776, IPR012001): Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
3 ACAT1interactor100.41726.800Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 ADAinteractor21.0000A_deaminase (PF00962, IPR001365): Adenosine/AMP deaminase
5 ADRB2interactor50.5000.9087tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
6 ATP1B1interactor110.50914.617Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
7 ATP5MGinteractor70.5245.117ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
8 ATXN1protein found in more fusions31.0000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
9 BCL10suppressor50.333229.400CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
10 CARD11oncoprotein31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
11 CCL22interactor100IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
12 CEP76interactor100Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
CEP76-C2 (PF15627, IPR028926): CEP76 C2 domain
13 CLN3interactor50.7001.022CLN3 (PF02487, IPR003492): CLN3 protein
14 CUL3protein found in more fusions130.303385.386Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
15 CYC1interactor130.42326.808Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
16 DKK1suppressor100Dickkopf_N (PF04706, IPR006796): Dickkopf N-terminal cysteine-rich region
UPF0506 (PF11703, IPR021712): UPF0506
17 ECT2suppressor70.33325.495BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
18 EGFRoncoprotein100.41714.133Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
19 FAF2interactor80.38117.357DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
20 FAPinteractor21.0000DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
21 FLOT1interactor30.6670.667CrtC (PF07143, IPR010791): CrtC N-terminal lipocalin domain
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
Flot (PF15975, IPR031905): Flotillin
22 GBA2interactor100DUF608 (PF04685, IPR006775): Glycosyl-hydrolase family 116, catalytic region
Glyco_hydr_116N (PF12215, IPR024462): beta-glucosidase 2, glycosyl-hydrolase family 116 N-term
23 HNRNPCprotein found in more fusions70.4678.550APG6 (PF04111, IPR007243): Autophagy protein Apg6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
24 HSD17B14interactor200adh_short_C2 (PF13561): Enoyl-(Acyl carrier protein) reductase
25 IKBKBprotein found in more fusions40.333286.600FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
26 ILKsuppressor60.6004.667Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
27 KIF11protein found in more fusions31.0000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
28 MMS19interactor60.6006.212DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
29 MTCH1interactor60.5332.856YdjM (PF04307, IPR007404): LexA-binding, inner membrane-associated putative hydrolase
Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
30 MYConcoprotein90.5366.686HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
31 NDUFS3protein found in more fusions130.36448.390Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
32 NTRK1oncoprotein210.242197.213I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
33 PICALMoncoprotein50.5003.567ANTH (PF07651, IPR011417): ANTH domain
34 PPP6R1interactor40.8330.667CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
35 PPP6R2interactor40.6672.000SAMP (PF05924, IPR009224): SAMP Motif
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
36 RAB14oncoprotein30.6670.667Ras (PF00071, IPR001806, SM00173): Ras family
37 RAB1Aoncoprotein80.5008.539Ras (PF00071, IPR001806, SM00173): Ras family
38 RPGRIP1Linteractor21.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
C2 (PF00168, IPR000008, SM00239): C2 domain
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FtsL (PF04999, IPR011922): Cell division protein FtsL
T3SS_needle_F (PF09392, IPR021123): Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
C2-C2_1 (PF11618, IPR021656): First C2 domain of RPGR-interacting protein 1
BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4497 (PF14924): Protein of unknown function (DUF4497)
39 SDHBsuppressor60.6007.395Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
40 SKA1interactor100SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
41 SLC25A3interactor130.32158.424Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
42 SRSF1protein found in more fusions60.400289.400Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
43 TCTN3interactor30.6670.400DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
44 TOM1oncoprotein21.0000GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
45 UBL4Ainteractor70.3339.467ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
46 UQCRFS1interactor80.5369.083Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
47 UQCRQinteractor100.42212.575UcrQ (PF02939, IPR004205): UcrQ family
48 VDAC2interactor110.36420.850Porin_3 (PF01459, IPR027246): Eukaryotic porin
49 VDAC3interactor80.5716.322Porin_3 (PF01459, IPR027246): Eukaryotic porin
50 XRCC6oncoprotein50.6670.833Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain

B a c k    t o    T o p ⇑