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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ACTA2, RNA45SN2 (from a repository: Sat Aug 17 10:01:23 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)84
The number (and %) of the onco-proteins26 (30.95 %)
The number (and %) of the tumor suppressors10 (11.90 %)
Total number of binary PPIs (saturation %)415 (11.90 %)
The number (and %) of affected PPIs82 (19.76 %)
The number of possible different fusions20
PPI diameter2
PPI radiusinf
The average degree of PPI9.214
Assortativity coefficient-0.4070
The network average Clustering coefficient0.424
The number (and %) of a zero Clustering coefficients24 (28.57 %)
The number (and %) of a zero Betweenness Centrality28 (33.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RNA45SN2,ACTA2 All fusions
Proteins found in more fusions UBE3A (see 1 fusions); ERBB3 (see 2 fusions); CREBBP (see 6 fusions); LGALS3 (see 2 fusions); TPM1 (see 2 fusions); SMURF2 (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); COPS5 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); EP300 (see 1 fusions); LRRK2 (see 1 fusions); RPA1 (see 1 fusions); UBAP1 (see 1 fusions); ERRFI1 (see 1 fusions); PARK2 (see 1 fusions); KCNMA1 (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RNA45SN2interactor000NA
2 ACTA2parental protein820.0924895.233Actin (PF00022, IPR004000, SM00268): Actin
3 AARSinteractor100DHHA1 (PF02272, IPR003156): DHHA1 domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
4 ACTC1interactor70.2869.986Actin (PF00022, IPR004000, SM00268): Actin
5 ADRA1Dinteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
6 ALOX12oncoprotein200Lipoxygenase (PF00305, IPR013819): Lipoxygenase
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
7 ARAFoncoprotein41.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
8 CAND1interactor210.60042.281Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
9 CAPNS2interactor100EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
10 CASQ2interactor100Calsequestrin (PF01216, IPR001393): Calsequestrin
SDA1 (PF05285, IPR007949): SDA1
11 CCT4interactor70.6192.017Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
12 CCT5interactor50.7000.387Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
13 CNN2interactor40.8330.500Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
14 COPS5protein found in more fusions210.61128.028JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
15 CREBBPsuppressor60.8001.000Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
16 CUL1suppressor220.44857.445Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
17 CUL2suppressor150.60024.032Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
18 CUL3protein found in more fusions280.370123.988Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
19 CUL4Boncoprotein130.7056.515Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
20 DHCR24interactor40.6670.867FAD_binding_4 (PF01565, IPR006094): FAD binding domain
21 DUSP19interactor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
22 EGFRoncoprotein190.22284.283Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
23 EP300oncoprotein70.6003.133Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
24 ERBB3oncoprotein40.6670.500Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
25 ERRFI1suppressor60.6001.733GTPase_binding (PF09027, IPR015116): GTPase binding
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
26 FSCN1oncoprotein50.6003.000Fascin (PF06268, IPR022768): Fascin domain
27 GSTP1suppressor60.7000.478GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
28 ICE2interactor100NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
29 KCNMA1protein found in more fusions200BK_channel_a (PF03493, IPR003929): Calcium-activated BK potassium channel alpha subunit
Ion_trans (PF00520, IPR005821): Ion transport protein
TrkA_N (PF02254, IPR003148): TrkA-N domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
SUZ (PF12752, IPR024771): SUZ domain
30 LGALS3oncoprotein60.4004.333Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
31 LRRK2oncoprotein80.5714.533Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
PQQ_2 (PF13360, IPR002372): PQQ-like domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
32 LRRTM2interactor100LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
33 MAP1LC3Cinteractor21.0000Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
34 MCM2oncoprotein260.293124.068AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
35 MRPL47interactor100MRP-L47 (PF06984, IPR010729): Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
36 MRPS2interactor40.6671.200Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
37 MRPS7interactor80.5008.900DUF454 (PF04304, IPR007401): Protein of unknown function (DUF454)
Ribosomal_S7 (PF00177, IPR023798): Ribosomal protein S7p/S5e
38 MYH10interactor100.53313.590IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
39 MYH11oncoprotein70.4766.686IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
40 MYH9suppressor140.48425.073IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
41 MYO1Cinteractor100.6678.221IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
42 MYOCinteractor50.5002.333IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
43 NCF1interactor31.0000p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
NECFESHC (PF16621, IPR032136): SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
44 NOP56interactor130.8722.694Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
45 PARK2suppressor100.38911.752IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
46 PCYT1Binteractor100ApoC-I (PF04691, IPR006781): Apolipoprotein C-I (ApoC-1)
CTP_transf_like (PF01467, IPR004821): Cytidylyltransferase-like
FTO_CTD (PF12934, IPR024366): FTO C-terminal domain
47 PECRinteractor100adh_short_C2 (PF13561): Enoyl-(Acyl carrier protein) reductase
48 PNMA1oncoprotein100PNMA (PF14893, IPR026523): PNMA
49 PPP1R1Aoncoprotein100DARPP-32 (PF05395, IPR008466): Protein phosphatase inhibitor 1/DARPP-32
50 PRG2interactor100Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF4628 (PF15429, IPR027851): Domain of unknown function (DUF4628)
51 RBM18interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
52 RPA1suppressor140.61510.097Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
53 RPA2oncoprotein150.53320.068RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
54 RPA3interactor140.60310.686Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
55 RPL10Ainteractor190.71313.712Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
56 RPL14interactor190.7439.569KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
57 RPL17interactor170.72812.702Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e
58 RPL18interactor230.60933.498Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
59 RPL7Ainteractor170.65423.577Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
60 RPS15Ainteractor210.60535.077Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
61 RPS16interactor210.67119.979Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
62 RPS23interactor150.8483.141Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
63 RPS26interactor140.7917.915Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e
64 RPS4Xinteractor200.72610.912KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e
RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain
S4 (PF01479, IPR002942, SM00363): S4 domain
40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus
65 SELEoncoprotein100EGF (PF00008, IPR000742, SM00181): EGF-like domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
66 SHBGoncoprotein31.0000Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
67 SMURF2protein found in more fusions50.5001.400C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
68 SPTAN1oncoprotein100.6228.425EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
69 TFDP3interactor100DP (PF08781, IPR014889, SM01138): Transcription factor DP
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
70 THAP11interactor200THAP (PF05485, IPR006612, SM00980): THAP domain
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
MRP-S31 (PF15433, IPR026299): Mitochondrial 28S ribosomal protein S31
FAM76 (PF16046, IPR032017): FAM76 protein
71 TP53suppressor260.270141.272DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
72 TPM1protein found in more fusions120.32729.483Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
73 TRIM9interactor40.6671.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Fer4_4 (PF12800, IPR001450): 4Fe-4S binding domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
74 UBAP1protein found in more fusions200MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UPF0054 (PF02130, IPR002036): Uncharacterized protein family UPF0054
75 UBE3Aoncoprotein70.4675.301HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
76 UBL4Ainteractor130.51322.288ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
77 UBXN4interactor100Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
78 YBX1oncoprotein110.52715.477CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
79 YIPF2interactor100Yip1 (PF04893, IPR006977): Yip1 domain
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
80 YWHABinteractor80.6074.41714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
81 YWHAEoncoprotein150.28645.19214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
82 YWHAQinteractor150.33344.85314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
83 ZMAT3interactor100zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-met (PF12874): Zinc-finger of C2H2 type
84 ZYXsuppressor50.6003.167DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
LIM (PF00412, IPR001781, SM00132): LIM domain
DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)

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