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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SYCP2, TXNL4A (from a repository: Mon Aug 5 07:25:20 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins7 (25.93 %)
The number (and %) of the tumor suppressors3 (11.11 %)
Total number of binary PPIs (saturation %)54 (15.38 %)
The number (and %) of affected PPIs25 (46.30 %)
The number of possible different fusions4
PPI diameter4
PPI radius2
The average degree of PPI3.333
Assortativity coefficient-0.5054
The network average Clustering coefficient0.435
The number (and %) of a zero Clustering coefficients12 (44.44 %)
The number (and %) of a zero Betweenness Centrality18 (66.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SYCP2,TXNL4A All fusions
Proteins found in more fusions EXOC5 (see 1 fusions); PRPF6 (see 1 fusions); SRPK2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SYCP2parental protein100NA
2 TXNL4Aparental protein240.069573.333DIM1 (PF02966, IPR004123): Mitosis protein DIM1
3 CBR1interactor100adh_short (PF00106, IPR002198): short chain dehydrogenase
4 DDX23interactor51.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Transformer (PF06495, IPR010519): Fruit fly transformer protein
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF3698 (PF12479, IPR022167): Protein of unknown function (DUF3698)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
5 EXOC5protein found in more fusions200Sec10 (PF07393, IPR009976): Exocyst complex component Sec10
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
6 GRIA2interactor100ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
7 GSTP1suppressor200GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
8 HNRNPFinteractor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
9 ID1interactor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
10 KIFC3oncoprotein31.0000Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
11 KRASoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
12 LZTS2suppressor50.4006.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127)
Fez1 (PF06818): Fez1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
13 NANOGinteractor200Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
14 PQBP1interactor21.0000WW (PF00397, IPR001202, SM00456): WW domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
15 PRPF4interactor61.0000PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
16 PRPF6protein found in more fusions70.8003.333PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
17 REToncoprotein31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
18 RHEBL1interactor100Ras (PF00071, IPR001806, SM00173): Ras family
19 SNRNP40interactor60.8003.333WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
20 SRPK2oncoprotein3050.000DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
21 SYNCRIPinteractor30.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
22 TSNAXinteractor30.6671.000Translin (PF01997, IPR002848): Translin family
23 TSSC4suppressor40.6672.000TSSC4 (PF15264, IPR029338): Tumour suppressing sub-chromosomal transferable candidate 4
24 UNKinteractor21.0000MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
25 USP39oncoprotein60.66796.000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
26 USP43interactor100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
27 WDFY1interactor100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
ELYS-bb (PF16687, IPR032040): beta-propeller of ELYS nucleoporin

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