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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TSPAN9, MAML1 (from a repository: Thu May 23 10:11:24 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins7 (30.43 %)
The number (and %) of the tumor suppressors8 (34.78 %)
Total number of binary PPIs (saturation %)65 (25.69 %)
The number (and %) of affected PPIs21 (32.31 %)
The number of possible different fusions6
PPI diameter4
PPI radius2
The average degree of PPI4.870
Assortativity coefficient-0.5151
The network average Clustering coefficient0.626
The number (and %) of a zero Clustering coefficients3 (13.04 %)
The number (and %) of a zero Betweenness Centrality13 (56.52 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAML1,TSPAN9 All fusions
Proteins found in more fusions PIAS1 (see 2 fusions); CREBBP (see 6 fusions); HUWE1 (see 2 fusions); EWSR1 (see 2 fusions); EP300 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAML1parental protein200.163244.119MamL-1 (PF09596, IPR019082): MamL-1 domain
Kri1 (PF05178, IPR018034): KRI1-like family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
2 TSPAN9parental protein100Tetraspannin (PF00335, IPR018499): Tetraspanin family
3 CDK8interactor41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
4 CREBBPsuppressor80.42921.310Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
5 ELAVL1oncoprotein60.20045.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 EP300oncoprotein60.7002.167Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
7 EWSR1oncoprotein50.6676.238RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
8 HDAC9interactor31.0000Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
CEP19 (PF14933, IPR029412): CEP19-like protein
9 HUWE1oncoprotein31.0000BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
10 MAML2oncoprotein50.7001.667Senescence_reg (PF04520, IPR007608): Senescence regulator
BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
MamL-1 (PF09596, IPR019082): MamL-1 domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
11 MAML3interactor31.0000Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Rtf2 (PF04641, IPR027799): Rtf2 RING-finger
MamL-1 (PF09596, IPR019082): MamL-1 domain
DUF2459 (PF09601, IPR011727): Protein of unknown function (DUF2459)
Kin17_mid (PF10357, IPR019447): Domain of Kin17 curved DNA-binding protein
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
SprA-related (PF12118, IPR021973): SprA-related family
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
AAA_23 (PF13476): AAA domain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
FAM70 (PF14967, IPR028014): FAM70 protein
12 NOTCH1suppressor130.31835.071Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
13 NOTCH2suppressor31.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
14 NOTCH3suppressor31.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
15 NOTCH4oncoprotein100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Lem_TRP (PF08262, IPR013206): Leucophaea maderae tachykinin-related peptide
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
16 PBRM1suppressor31.0000BAH (PF01426, IPR001025, SM00439): BAH domain
BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504)
17 PHF8interactor31.0000JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
PHD (PF00628, IPR019787, SM00249): PHD-finger
TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
18 PIAS1suppressor200Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
19 RBPJinteractor120.28865.548BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
20 RND3suppressor31.0000Ras (PF00071, IPR001806, SM00173): Ras family
21 SMARCA4suppressor70.42913.143DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065)
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
22 XPO1interactor40.5009.238CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
23 ZMIZ1oncoprotein31.0000zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger

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