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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins9 (20.45 %)
The number (and %) of the tumor suppressors3 (6.82 %)
Total number of binary PPIs (saturation %)162 (17.12 %)
The number (and %) of affected PPIs42 (25.93 %)
The number of possible different fusions6
PPI diameter4
PPI radius2
The average degree of PPI6.500
Assortativity coefficient-0.4410
The network average Clustering coefficient0.548
The number (and %) of a zero Clustering coefficients11 (25.00 %)
The number (and %) of a zero Betweenness Centrality19 (43.18 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions TSG101 (see 2 fusions); STAT3 (see 2 fusions); COPS5 (see 1 fusions); FMNL1 (see 1 fusions); G3BP1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NUFIP2parental protein410.1181401.255PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
NUFIP2 (PF15293, IPR032747): Nuclear fragile X mental retardation-interacting protein 2
2 PDE10Aparental protein100GAF (PF01590, IPR003018, SM00065): GAF domain
PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
3 BMI1oncoprotein61.0000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
4 CHRNA9interactor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
5 COPS5protein found in more fusions90.50043.600JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
6 CRKoncoprotein30.6671.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
7 DDX6oncoprotein90.30629.419DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
8 DYNLT1interactor100Tctex-1 (PF03645, IPR005334): Tctex-1 family
9 EFEMP2interactor100EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Adipogenin (PF15202, IPR027938): Adipogenin
10 ELAVL1oncoprotein120.40064.219RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11 FMNL1protein found in more fusions200CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
SlyX (PF04102, IPR007236): SlyX
FNIP_M (PF14637, IPR028085): Folliculin-interacting protein middle domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
12 FMR1interactor41.0000Agenet (PF05641, IPR008395, SM00743): Agenet domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXMR_C2 (PF16098, IPR032196): Fragile X-related mental retardation protein C-terminal region 2
13 G3BP1protein found in more fusions100.58311.186NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
14 G3BP2interactor80.7143.686NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
15 KLHL20interactor31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
16 KRTAP10-3interactor140.66712.883Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
17 KRTAP10-5interactor110.7564.758Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
18 KRTAP10-7interactor120.70911.244Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
19 KRTAP10-8interactor140.65413.325Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
20 KRTAP10-9interactor120.8003.758Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
21 KRTAP3-2interactor51.0000Keratin_matx (PF04579, IPR007659): Keratin, high-sulphur matrix protein
22 KRTAP3-3interactor100Keratin_matx (PF04579, IPR007659): Keratin, high-sulphur matrix protein
23 KRTAP4-11interactor51.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
24 KRTAP4-12interactor110.7335.678Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
25 KRTAP4-2interactor100.9110.944Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
26 KRTAP5-6interactor110.8731.702NA
27 KRTAP5-9interactor130.7317.836Ery_res_leader2 (PF08057, IPR012559): Erythromycin resistance leader peptide
28 KRTAP9-2interactor130.7736.536Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
29 KRTAP9-4interactor80.9290.444Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
30 LACC1interactor100Cu-oxidase_4 (PF02578, IPR003730): Multi-copper polyphenol oxidoreductase laccase
31 LGALS13interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
32 MED4interactor21.0000Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
33 MEX3Cinteractor21.0000KH_1 (PF00013, IPR004088, SM00322): KH domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
34 PCSK5interactor60.9330.222P_proprotein (PF01483, IPR002884): Proprotein convertase P-domain
Peptidase_S8 (PF00082, IPR000209): Subtilase family
VSP (PF03302, IPR005127): Giardia variant-specific surface protein
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
Furin-like_2 (PF15913, IPR006212): Furin-like repeat, cysteine-rich
S8_pro-domain (PF16470, IPR032815): Peptidase S8 pro-domain
35 RGS17interactor100RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
36 RPL10suppressor70.6195.252Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
37 SH3RF2interactor30.6670.400SH3_2 (PF07653, IPR011511): Variant SH3 domain
TUDOR (PF00567, IPR002999, SM00333): Tudor domain
UPF0547 (PF10571, IPR018886): Uncharacterised protein family UPF0547
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
SH3_9 (PF14604, IPR001452): Variant SH3 domain
38 SIRT7interactor60.53335.467DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
39 STAT3suppressor50.6673.333SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
40 TARDBPinteractor90.57140.767RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
41 TOP1oncoprotein50.30085.086DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
TonB_N (PF16031): TonB N-terminal region
42 TRAF1oncoprotein200HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
43 TSG101suppressor31.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
44 UNKinteractor100MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain

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