Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins SEPT9, CABP1 (from a repository: Thu Aug 8 12:43:34 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 62 The number (and %) of the onco-proteins 18 (29.03 %) The number (and %) of the tumor suppressors 7 (11.29 %) Total number of binary PPIs (saturation %) 249 (13.17 %) The number (and %) of affected PPIs 60 (24.10 %) The number of possible different fusions 14 PPI diameter 5 PPI radius 3 The average degree of PPI 7.290 Assortativity coefficient -0.1752 The network average Clustering coefficient 0.503 The number (and %) of a zero Clustering coefficients 11 (17.74 %) The number (and %) of a zero Betweenness Centrality 15 (24.19 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SEPTIN9,CABP1	All fusions
Proteins found in more fusions	FOS (see 4 fusions); HNRNPD (see 1 fusions); APP (see 5 fusions); TPM3 (see 3 fusions); GRK5 (see 2 fusions); COPA (see 1 fusions); MSH2 (see 1 fusions); SH3KBP1 (see 1 fusions); NEDD4 (see 1 fusions); NCL (see 4 fusions); NTRK1/TPM3 (see 2 fusions); U2AF2 (see 2 fusions); SNW1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SEPT9	parental protein	53	0.117	2252.548	Septin (PF00735, IPR000038): Septin DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
2	CABP1	parental protein	7	0	370.800	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
3	ANLN	oncoprotein	10	0.444	17.856	Anillin (PF08174, IPR012966): Cell division protein anillin PH (PF00169, IPR001849, SM00233): PH domain Anillin_N (PF16018, IPR031970): Anillin N-terminus
4	APP	protein found in more fusions	11	0.200	208.284	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5	CACNA1A	interactor	2	0	46.476	Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain GRP (PF07172, IPR010800): Glycine rich protein family Ion_trans (PF00520, IPR005821): Ion transport protein Roughex (PF06020, IPR009259): Drosophila roughex protein SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
6	CACNA1C	interactor	1	0	0	Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain Ion_trans (PF00520, IPR005821): Ion transport protein Rer1 (PF03248, IPR004932): Rer1 family ODV-E18 (PF10717, IPR019655): Occlusion-derived virus envelope protein ODV-E18 DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) CAC1F_C (PF16885, IPR031688): Voltage-gated calcium channel subunit alpha, C-term GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
7	CDC42EP4	interactor	7	0.762	7.653	PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain BORG_CEP (PF14957, IPR029273): Cdc42 effector
8	CDC5L	interactor	14	0.603	16.858	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
9	CFTR	suppressor	8	0.381	10.400	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
10	COPA	protein found in more fusions	10	0.500	17.908	Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region COPI_C (PF06957, IPR010714): Coatomer (COPI) alpha subunit C-terminus WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
11	DDA1	interactor	2	1.000	0	DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
12	EED	suppressor	9	0.750	2.138	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
13	FERMT2	interactor	5	0.500	7.197	FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
14	FLNB	oncoprotein	5	0.500	2.022	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat PapC_N (PF13954, IPR025885): PapC N-terminal domain
15	FN1	oncoprotein	12	0.242	41.704	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
16	FOS	oncoprotein	3	0	86.431	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
17	GRK5	protein found in more fusions	4	0	161.864	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
18	HAUS1	interactor	3	1.000	0	THP2 (PF09432, IPR018557): Tho complex subunit THP2 XhlA (PF10779, IPR019715): Haemolysin XhlA DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
19	HIF1A	suppressor	2	1.000	0	Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
20	HNRNPD	oncoprotein	11	0.622	7.829	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head
21	HSPA5	oncoprotein	15	0.615	17.166	HSP70 (PF00012, IPR013126): Hsp70 protein
22	HSPD1	suppressor	12	0.561	28.758	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
23	IKBKG	interactor	3	1.000	0	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
24	ITPR1	interactor	1	0	0	Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor Ion_trans (PF00520, IPR005821): Ion transport protein MIR (PF02815, IPR016093, SM00472): MIR domain RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated RYDR_ITPR (PF01365, IPR000699): RIH domain CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
25	JPT1	interactor	1	0	0	JUPITER (PF17054): Microtubule-Associated protein Jupiter
26	MSH2	suppressor	6	0.900	0.250	MutS_I (PF01624, IPR007695): MutS domain I MutS_II (PF05188, IPR007860): MutS domain II MutS_V (PF00488, IPR000432, SM00534): MutS domain V MutS_III (PF05192, IPR007696, SM00533): MutS domain III AAA_27 (PF13514): AAA domain
27	NCL	protein found in more fusions	9	0.500	99.691	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Myc_N (PF01056, IPR012682): Myc amino-terminal region RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YL1 (PF05764, IPR008895): YL1 nuclear protein Limkain-b1 (PF11608, IPR024582): Limkain b1
28	NDUFV2	interactor	5	0.400	5.000	2Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
29	NEDD4	suppressor	4	0.667	1.800	Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
30	NMT1	oncoprotein	2	0	142.362	NMT (PF01233, IPR022676): Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C (PF02799, IPR022677): Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein NST1 (PF13945, IPR025279): Salt tolerance down-regulator
31	NTRK1	oncoprotein	21	0.268	337.992	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
32	OBSL1	interactor	15	0.396	38.162	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
33	PPP3R1	interactor	1	0	0	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
34	RIDA	interactor	3	1.000	0	Ribonuc_L-PSP (PF01042, IPR006175): Endoribonuclease L-PSP
35	SCO2	interactor	5	0.500	10.952	SCO1-SenC (PF02630, IPR003782): SCO1/SenC
36	SCP2	interactor	5	0.400	143.709	SCP2 (PF02036, IPR003033): SCP-2 sterol transfer family Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
37	SEC22B	interactor	8	0.286	17.556	Synaptobrevin (PF00957, IPR001388): Synaptobrevin Longin (PF13774, IPR010908): Regulated-SNARE-like domain
38	SEPT1	interactor	8	0.762	7.653	Pet20 (PF08692, IPR014804): Mitochondrial protein Pet20 Septin (PF00735, IPR000038): Septin SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
39	SEPT11	interactor	12	0.439	29.319	Septin (PF00735, IPR000038): Septin DUF3080 (PF11279, IPR021431): Protein of unknown function (DUF3080)
40	SEPT2	oncoprotein	17	0.449	55.685	FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger Septin (PF00735, IPR000038): Septin
41	SEPT3	interactor	8	0.952	0.286	Septin (PF00735, IPR000038): Septin
42	SEPT6	oncoprotein	13	0.500	22.071	Septin (PF00735, IPR000038): Septin DUF2959 (PF11172, IPR021342): Protein of unknown function (DUF2959)
43	SEPT7	interactor	15	0.514	31.526	Fez1 (PF06818): Fez1 Septin (PF00735, IPR000038): Septin
44	SH3KBP1	protein found in more fusions	8	0.810	4.411	Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein SH3_9 (PF14604, IPR001452): Variant SH3 domain
45	SNW1	protein found in more fusions	16	0.543	34.287	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
46	SRRM2	interactor	15	0.467	197.327	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
47	STK11	suppressor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
48	SUCLG1	interactor	3	0.667	0.667	CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain Ligase_CoA (PF00549, IPR005811): CoA-ligase CoA_binding_2 (PF13380, IPR003781): CoA binding domain
49	SUCLG2	interactor	4	0.500	2.167	ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain Ligase_CoA (PF00549, IPR005811): CoA-ligase
50	SVIL	interactor	4	0.500	2.667	Gelsolin (PF00626, IPR007123): Gelsolin repeat VHP (PF02209, IPR003128, SM00153): Villin headpiece domain DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
51	TIMM44	interactor	4	0.667	3.667	Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211) AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3 RecG_N (PF17190): RecG N-terminal helical domain
52	TMED9	interactor	3	0.667	0.500	EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
53	TOR1AIP1	interactor	2	1.000	0	LAP1C (PF05609, IPR008662): Lamina-associated polypeptide 1C (LAP1C) Pap_E4 (PF02711, IPR003861): E4 protein
54	TPM3	oncoprotein	6	0.400	3.327	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
55	U2AF2	protein found in more fusions	14	0.692	9.053	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
56	UBXN6	interactor	3	0.667	2.000	PUB (PF09409, IPR018997): PUB domain UBX (PF00789, IPR001012, SM00166): UBX domain
57	UQCRFS1	interactor	2	1.000	0	Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
58	UQCRFS1P1	interactor	1	0	0	NA
59	VAMP2	interactor	3	1.000	0	Synaptobrevin (PF00957, IPR001388): Synaptobrevin PRIMA1 (PF16101): Proline-rich membrane anchor 1
60	VAPB	interactor	5	0.500	11.556	ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit ZapB (PF06005, IPR009252): Cell division protein ZapB Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
61	VMA21	interactor	1	0	0	VMA21 (PF09446, IPR019013): VMA21-like domain
62	XPO1	interactor	11	0.364	28.465	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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