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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PPP6R2, ADCY2 (from a repository: Fri Nov 1 08:42:38 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)41
The number (and %) of the onco-proteins13 (31.71 %)
The number (and %) of the tumor suppressors4 (9.76 %)
Total number of binary PPIs (saturation %)153 (18.66 %)
The number (and %) of affected PPIs39 (25.49 %)
The number of possible different fusions9
PPI diameter5
PPI radius3
The average degree of PPI6.927
Assortativity coefficient-0.3516
The network average Clustering coefficient0.580
The number (and %) of a zero Clustering coefficients5 (12.20 %)
The number (and %) of a zero Betweenness Centrality12 (29.27 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ADCY2,PPP6R2 All fusions
Proteins found in more fusions AP2M1 (see 4 fusions); GNAS (see 5 fusions); APP (see 5 fusions); ATXN1 (see 3 fusions); ADCY5 (see 1 fusions); PRKDC (see 2 fusions); AURKA (see 1 fusions); PPP6R2/PFDN5 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ADCY2parental protein2078.000DUF1053 (PF06327, IPR009398): Domain of Unknown Function (DUF1053)
HNOBA (PF07701, IPR011645): Heme NO binding associated
Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain
DUF3487 (PF11990, IPR021877): Protein of unknown function (DUF3487)
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
2 PPP6R2parental protein370.150831.196SAMP (PF05924, IPR009224): SAMP Motif
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
3 ACSL3oncoprotein40.6671.333AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
4 ADCY5protein found in more fusions200DUF1053 (PF06327, IPR009398): Domain of Unknown Function (DUF1053)
HNOBA (PF07701, IPR011645): Heme NO binding associated
Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain
DUF3566 (PF12089, IPR021949): Transmembrane domain of unknown function (DUF3566)
DUF4191 (PF13829, IPR025445): Domain of unknown function (DUF4191)
HILPDA (PF15220, IPR026190): Hypoxia-inducible lipid droplet-associated
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
5 AIPsuppressor100FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
6 ALDH3A2interactor21.0000Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
7 ANKRD28interactor140.42935.729Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
8 ANKRD44oncoprotein80.8212.300Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
9 ANKRD52interactor110.49116.029Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
10 AP2M1protein found in more fusions70.4672.938Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
11 APPprotein found in more fusions110.26723.533APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
12 ATXN1protein found in more fusions31.0000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
13 AURKAoncoprotein70.6003.067Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
14 CACYBPinteractor31.0000CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
Siah-Interact_N (PF09032, IPR015120): Siah interacting protein, N terminal
15 DCLRE1Cinteractor50.7000.819DRMBL (PF07522, IPR011084): DNA repair metallo-beta-lactamase
DUF3290 (PF11694, IPR021707): Protein of unknown function (DUF3290)
Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
16 DPCDinteractor31.0000DPCD (PF14913): DPCD protein family
17 GNASoncoprotein50.333152.667G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
18 ILVBLinteractor40.6673.500TPP_enzyme_C (PF02775, IPR011766): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
TPP_enzyme_N (PF02776, IPR012001): Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
19 MOB1Asuppressor90.7503.567Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
20 MOB1Bsuppressor80.7862.233Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
21 NTRK1oncoprotein170.350154.203I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
22 NUDCinteractor31.0000CS (PF04969, IPR007052): CS domain
D5_N (PF08706, IPR014818, SM00885): D5 N terminal like
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Nudc_N (PF14050, IPR025934): N-terminal conserved domain of Nudc.
NuDC (PF16273, IPR032572): Nuclear distribution C domain
23 PFDN2interactor50.7002.667Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
24 PFDN5protein found in more fusions41.0000Prefoldin (PF02996, IPR004127): Prefoldin subunit
UPF0693 (PF16088, IPR032143): UPF0693 family
25 PFDN6interactor50.7002.400BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
26 PLK1suppressor80.4299.567Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
27 PNKDinteractor30.6670.333Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
HAGH_C (PF16123, IPR032282): Hydroxyacylglutathione hydrolase C-terminus
28 PPP6Cinteractor130.60314.862Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
29 PPP6R1interactor220.281153.877CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
30 PPP6R3interactor140.53823.429SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
31 PRG2interactor21.0000Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF4628 (PF15429, IPR027851): Domain of unknown function (DUF4628)
32 PRKDCprotein found in more fusions80.6194.083FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
33 RUVBL2oncoprotein90.42917.348TIP49 (PF06068, IPR010339): TIP49 C-terminus
34 SDCBPinteractor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
35 SH3GLB2interactor100BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
36 TBK1interactor80.7143.519DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Pkinase (PF00069, IPR000719): Protein kinase domain
37 TTC1interactor30.66721.919TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
38 USP49interactor50.9000.200UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
39 WDR92interactor30.6671.667WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Itfg2 (PF15907, IPR031793): Integrin-alpha FG-GAP repeat-containing protein 2
40 WNT10Boncoprotein100wnt (PF00110, IPR005817, SM00097): wnt family
41 XPO1interactor130.397107.015CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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