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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GOLPH3, ADCY2 (from a repository: Wed Jul 31 20:29:36 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)31
The number (and %) of the onco-proteins5 (16.13 %)
The number (and %) of the tumor suppressors2 (6.45 %)
Total number of binary PPIs (saturation %)55 (11.83 %)
The number (and %) of affected PPIs29 (52.73 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.774
Assortativity coefficient-0.3500
The network average Clustering coefficient0.480
The number (and %) of a zero Clustering coefficients14 (45.16 %)
The number (and %) of a zero Betweenness Centrality25 (80.65 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ADCY2,GOLPH3 All fusions
Proteins found in more fusions ADCY5 (see 1 fusions); RCC1L (see 1 fusions); GNAS (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ADCY2parental protein202.000DUF1053 (PF06327, IPR009398): Domain of Unknown Function (DUF1053)
HNOBA (PF07701, IPR011645): Heme NO binding associated
Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain
DUF3487 (PF11990, IPR021877): Protein of unknown function (DUF3487)
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
2 GOLPH3parental protein270.040667.667GPP34 (PF05719, IPR008628): Golgi phosphoprotein 3 (GPP34)
3 ADCY5protein found in more fusions200DUF1053 (PF06327, IPR009398): Domain of Unknown Function (DUF1053)
HNOBA (PF07701, IPR011645): Heme NO binding associated
Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain
DUF3566 (PF12089, IPR021949): Transmembrane domain of unknown function (DUF3566)
DUF4191 (PF13829, IPR025445): Domain of unknown function (DUF4191)
HILPDA (PF15220, IPR026190): Hypoxia-inducible lipid droplet-associated
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
4 AIMP1suppressor100DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
tRNA_bind (PF01588, IPR002547): Putative tRNA binding domain
5 ARL6IP1interactor31.0000Reticulon (PF02453, IPR003388): Reticulon
TraG_N (PF07916, IPR012931): TraG-like protein, N-terminal region
6 C15orf48interactor31.0000B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
7 C3orf58interactor100PIP49_C (PF12260, IPR022049): Protein-kinase domain of FAM69
8 COQ8Ainteractor50.8330.667ABC1 (PF03109, IPR004147): ABC1 family
CbtA (PF09490, IPR012666): Probable cobalt transporter subunit (CbtA)
9 COQ8Binteractor41.0000ABC1 (PF03109, IPR004147): ABC1 family
10 COQ9interactor50.8330.667COQ9 (PF08511, IPR013718): COQ9
11 DCUN1D1interactor21.0000Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
12 ELAVL1oncoprotein50.5003.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
13 FAM20Binteractor21.0000Fam20C (PF06702, IPR009581): Golgi casein kinase, C-terminal, Fam20
FAM198 (PF15051, IPR029207): FAM198 protein
14 GMPPAinteractor31.0000Hexapep (PF00132, IPR001451): Bacterial transferase hexapeptide (six repeats)
NTP_transferase (PF00483, IPR005835): Nucleotidyl transferase
15 GMPPBinteractor21.0000Hexapep (PF00132, IPR001451): Bacterial transferase hexapeptide (six repeats)
NTP_transferase (PF00483, IPR005835): Nucleotidyl transferase
16 GNASoncoprotein200G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
17 NDUFA4interactor200B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
18 NME4interactor200NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
19 P2RY12interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
20 PFDN4interactor31.0000Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
21 PFDN5interactor31.0000Prefoldin (PF02996, IPR004127): Prefoldin subunit
UPF0693 (PF16088, IPR032143): UPF0693 family
22 PNKDinteractor100Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
HAGH_C (PF16123, IPR032282): Hydroxyacylglutathione hydrolase C-terminus
23 RANBP1interactor21.0000PKI (PF02827, IPR004171): cAMP-dependent protein kinase inhibitor
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
24 RASSF8suppressor100ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region
FliD_C (PF07195, IPR010809): Flagellar hook-associated protein 2 C-terminus
PEARLI-4 (PF05278, IPR007942): Arabidopsis phospholipase-like protein (PEARLI 4)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
25 RCC1Lprotein found in more fusions200RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
26 RUVBL2oncoprotein200TIP49 (PF06068, IPR010339): TIP49 C-terminus
27 SDHAF3interactor100Complex1_LYR_2 (PF13233): Complex1_LYR-like
28 SRMinteractor21.0000Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
29 TIPRLinteractor21.0000TIP41 (PF04176, IPR007303): TIP41-like family
30 TSR3interactor100DUF367 (PF04034, IPR007177): Domain of unknown function (DUF367)
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
31 VBP1interactor40.6672.000Prefoldin (PF02996, IPR004127): Prefoldin subunit

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