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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FGFR2, AHCYL1 (from a repository: Sun Aug 18 16:49:21 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)175
The number (and %) of the onco-proteins49 (28.00 %)
The number (and %) of the tumor suppressors24 (13.71 %)
Total number of binary PPIs (saturation %)927 (6.09 %)
The number (and %) of affected PPIs176 (18.99 %)
The number of possible different fusions34
PPI diameter4
PPI radius2
The average degree of PPI9.886
Assortativity coefficient-0.2389
The network average Clustering coefficient0.358
The number (and %) of a zero Clustering coefficients30 (17.14 %)
The number (and %) of a zero Betweenness Centrality36 (20.57 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FGFR2,AHCYL1 All fusions
Proteins found in more fusions APP (see 5 fusions); TPM1 (see 2 fusions); TLE3 (see 1 fusions); TKT (see 5 fusions); LYN (see 2 fusions); UBE2C (see 1 fusions); APP/SH3BGRL3 (see 1 fusions); TPM2/TPM1 (see 1 fusions); TPM3 (see 3 fusions); SRPK2 (see 1 fusions); PTS (see 1 fusions); FYN (see 1 fusions); VPS26A (see 1 fusions); PSME3 (see 2 fusions); STAT3 (see 2 fusions); UBQLN1 (see 2 fusions); TPM2 (see 1 fusions); UBE2D2 (see 1 fusions); DHX8/SRPK2 (see 1 fusions); AHCYL1 (see 2 fusions); STAT5B (see 1 fusions); PIK3R1 (see 1 fusions); SRSF1 (see 1 fusions); HSPA5/UBL7 (see 1 fusions); ECHS1 (see 1 fusions); SOD1/TAGLN2 (see 1 fusions); PDLIM2 (see 1 fusions); CDC37 (see 2 fusions); DHX8 (see 1 fusions); FGFR2 (see 3 fusions); TPD52L2 (see 2 fusions); ERRFI1 (see 1 fusions); NEDD4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FGFR2parental protein350.0414532.356Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
2 AHCYL1parental protein1410.06217343.067AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
3 AHCYinteractor31.0000AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
4 ANP32Asuppressor80.42999.614SDA1 (PF05285, IPR007949): SDA1
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_9 (PF14580): Leucine-rich repeat
5 ANP32Boncoprotein70.47645.242FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
SDA1 (PF05285, IPR007949): SDA1
LRR_9 (PF14580): Leucine-rich repeat
6 ANP32Einteractor31.0000BUD22 (PF09073, IPR015158): BUD22
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_9 (PF14580): Leucine-rich repeat
7 APPprotein found in more fusions280.0481723.943APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8 ATP6V1B2interactor160.36751.994ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF2481 (PF10654, IPR018916): Protein of unknown function (DUF2481)
9 BEX1interactor100BEX (PF04538, IPR021156): Brain expressed X-linked like family
10 BEX2suppressor100BEX (PF04538, IPR021156): Brain expressed X-linked like family
11 BIDoncoprotein50.5002.697BID (PF06393, IPR010479): BH3 interacting domain (BID)
12 C11orf58interactor30.6671.000DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
SMAP (PF15477, IPR028124): Small acidic protein family
13 C1QBPinteractor50.4004.352MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
14 C8orf74interactor100CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
15 CBLsuppressor170.150920.145Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
16 CCT5interactor50.4009.546Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
17 CD2BP2interactor70.38118.770GYF (PF02213, IPR003169, SM00444): GYF domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
18 CDC37protein found in more fusions110.333292.150CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
19 CDKN2Csuppressor30.33358.557Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
20 CEP128interactor50.30049.511DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
21 CSNK1Einteractor80.33338.157APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
22 DACH1suppressor31.0000DUF508 (PF04370, IPR007465): Domain of unknown function (DUF508)
Pap_E4 (PF02711, IPR003861): E4 protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
Macoilin (PF09726, IPR019130): Transmembrane protein
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
23 DHX8protein found in more fusions60.6003.045DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
24 DOK4interactor21.0000IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
25 ECHS1protein found in more fusions60.6003.114ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
26 ECT2suppressor70.3819.877BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
27 EDAinteractor21.0000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
28 EIF3Minteractor40.50012.725Death (PF00531, IPR000488, SM00005): Death domain
PCI (PF01399, IPR000717, SM00088): PCI domain
29 ELAVL1oncoprotein370.0971607.317RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
30 ERRFI1suppressor40.33382.947GTPase_binding (PF09027, IPR015116): GTPase binding
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
31 FAM13Cinteractor31.0000Mnd1 (PF03962, IPR005647): Mnd1 family
SlyX (PF04102, IPR007236): SlyX
MRI (PF15325, IPR028278): Modulator of retrovirus infection
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
32 FBXL7oncoprotein50.30036.348LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
33 FGF1oncoprotein200FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
34 FGF10oncoprotein100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
35 FGF23interactor100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
36 FGF5oncoprotein100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
37 FGF7oncoprotein2036.722FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
38 FGF8oncoprotein100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
TraC_F_IV (PF11130, IPR025955): F pilus assembly Type-IV secretion system for plasmid transfer
39 FRS2interactor40.66713.237IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
40 FYNoncoprotein60.7005.538Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
41 GEMinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
AAA_22 (PF13401, IPR003593): AAA domain
42 GINS4interactor40.5003.000Sld5 (PF05916, IPR021151): GINS complex protein
SLD5_C (PF16922, IPR031633): DNA replication complex GINS protein SLD5 C-terminus
43 GLCEinteractor2039.297C5-epim_C (PF06662, IPR010598): D-glucuronyl C5-epimerase C-terminus
EspG (PF06872, IPR009669): EspG protein
44 HGSinteractor130.2441353.408FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
45 HOXC6interactor21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
46 HOXC9interactor100Hox9_act (PF04617, IPR006711): Hox9 activation region
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
47 HSPA5oncoprotein180.265220.377HSP70 (PF00012, IPR013126): Hsp70 protein
48 ITGA5suppressor21.0000FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
49 ITPR1interactor100Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RYDR_ITPR (PF01365, IPR000699): RIH domain
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
50 JOSD2interactor21.0000Josephin (PF02099, IPR006155): Josephin
51 LAGE3interactor60.4007.031Pcc1 (PF09341, IPR015419): Transcription factor Pcc1
52 LYNoncoprotein70.46778.538Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
53 MAB21L3interactor100Mab-21 (PF03281, IPR024810): Mab-21 protein
54 MEOX2interactor40.5003.224Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
55 MOV10interactor250.107593.288AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
56 MTA3oncoprotein40154.737BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
57 MYL6interactor31.0000EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
58 NEDD4suppressor120.091447.500Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
59 NXF1interactor320.110723.414NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
60 PDCD6IPinteractor90.39359.205BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
61 PDLIM2protein found in more fusions200LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
62 PGRsuppressor80.190228.629Prog_receptor (PF02161, IPR000128): Progesterone receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
63 PIK3R1oncoprotein60.60020.926RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
64 PITX2interactor200OAR (PF03826, IPR003654): OAR domain
XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
65 PLCG1oncoprotein30.33341.411C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
66 POC1Ainteractor30.6671.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
67 PPIL3interactor110.30943.656Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
68 PPLinteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil
DivIC (PF04977, IPR007060): Septum formation initiator
MCU (PF04678, IPR006769): Mitochondrial calcium uniporter
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
FliT (PF05400, IPR008622): Flagellar protein FliT
M (PF02370, IPR003345): M protein repeat
Mnd1 (PF03962, IPR005647): Mnd1 family
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spectrin (PF00435, IPR002017): Spectrin repeat
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
69 PPM1Asuppressor100PP2C (PF00481, IPR001932): Protein phosphatase 2C
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
70 PPM1Ginteractor180.20393.467Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PP2C (PF00481, IPR001932): Protein phosphatase 2C
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
71 PPP2CAsuppressor50.4006.033Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
72 PSAT1interactor90.25067.034Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
73 PSMD12interactor70.6005.875Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
74 PSMD4interactor160.233217.227UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
75 PSMD6interactor50.8003.400RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
76 PSMD9interactor70.47622.662Remorin_C (PF03763, IPR005516): Remorin, C-terminal region
DUF2046 (PF09755, IPR019152): Uncharacterized conserved protein H4 (DUF2046)
PDZ_2 (PF13180, IPR001478): PDZ domain
77 PSME3protein found in more fusions90.35722.955PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
78 PTGES3interactor70.4675.567CS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
79 PTSprotein found in more fusions200PTPS (PF01242, IPR007115): 6-pyruvoyl tetrahydropterin synthase
80 RASL10Bsuppressor30.33340.418Ras (PF00071, IPR001806, SM00173): Ras family
81 RHOBTB2suppressor3021.339BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ras (PF00071, IPR001806, SM00173): Ras family
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
82 RPL37Ainteractor207.229Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
83 S100A14oncoprotein2040.629S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
84 SEC24Ainteractor180.150115.999Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
85 SEC24Cinteractor120.28884.356Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
86 SEPHS1interactor70.6008.782AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
87 SERPINH1interactor100.26732.015Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
88 SGTAinteractor60.33385.084TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_17 (PF13431): Tetratricopeptide repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
89 SH3BGRL3protein found in more fusions207.229SH3BGR (PF04908, IPR006993): SH3-binding, glutamic acid-rich protein
90 SHTN1interactor80.23844.845Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
VIT1 (PF01988, IPR008217): VIT family
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
91 SIN3Aoncoprotein90.222123.129Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
92 SKP1oncoprotein100.24490.060Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
93 SLC23A1interactor100Xan_ur_permease (PF00860, IPR006043): Permease family
94 SNCGoncoprotein31.0000Synuclein (PF01387, IPR001058): Synuclein
95 SNRPAinteractor40.6670.861RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
96 SNX12interactor60.40010.536PX (PF00787, IPR001683, SM00312): PX domain
97 SNX3interactor90.33331.550PX (PF00787, IPR001683, SM00312): PX domain
98 SOD1protein found in more fusions170.33359.098Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
99 SOX2oncoprotein120.291120.668HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
100 SOX30interactor100HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
101 SP100suppressor50.5002.912Pap_E4 (PF02711, IPR003861): E4 protein
PHD (PF00628, IPR019787, SM00249): PHD-finger
SAND (PF01342, IPR000770, SM00258): SAND domain
HSR (PF03172, IPR004865): HSR domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
102 SPRinteractor90.52812.260adh_short (PF00106, IPR002198): short chain dehydrogenase
103 SRPK1interactor110.34578.576FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
104 SRPK2oncoprotein130.33385.170DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
105 SRSF1protein found in more fusions110.35656.465Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
106 SRXN1interactor250.247149.047ParBc (PF02195, IPR003115): ParB-like nuclease domain
107 STAMinteractor160.308118.930GAT (PF03127, IPR004152): GAT domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
108 STAT3suppressor130.197523.432SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
109 STAT5Asuppressor40.6670.978SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
110 STAT5Boncoprotein50.6676.937SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
111 STAT6oncoprotein60.33355.421SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT6_C (PF14596, IPR028187): STAT6 C-terminal
112 STIP1interactor120.31890.116TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): WTAP/Mum2p family
113 STMN1interactor100.33334.227Stathmin (PF00836, IPR000956): Stathmin family
114 STMN2interactor60.6001.663Stathmin (PF00836, IPR000956): Stathmin family
115 STUB1suppressor240.198426.913U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
116 SUGT1interactor60.4009.140CheC (PF04509, IPR007597): CheC-like family
CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
117 SULT1A1interactor270.279161.248Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
118 SUMO2interactor60.40013.295Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
119 TACC3oncoprotein40.6670.404TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
120 TAGLN2protein found in more fusions180.261166.726Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
121 TARDBPinteractor100.33341.870RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
122 TBCAinteractor100TBCA (PF02970, IPR004226): Tubulin binding cofactor A
123 TESsuppressor70.33317.925LIM (PF00412, IPR001781, SM00132): LIM domain
PET (PF06297, IPR010442): PET Domain
PSCyt3 (PF07627, IPR013039): Protein of unknown function (DUF1588)
Ig_Tie2_1 (PF10430, IPR018941): Tie-2 Ig-like domain 1
124 TFF1oncoprotein40.33388.590Trefoil (PF00088, IPR000519, SM00018): Trefoil (P-type) domain
125 THADAoncoprotein90.33314.894HEAT (PF02985, IPR000357): HEAT repeat
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
DUF2428 (PF10350, IPR019442): Putative death-receptor fusion protein (DUF2428)
126 TKTprotein found in more fusions110.53315.102Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
127 TLE3protein found in more fusions90.32158.898TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
128 TMEM17interactor80.250413.467Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
129 TMOD3interactor70.42913.363Tropomodulin (PF03250, IPR004934): Tropomodulin
Usher (PF00577, IPR000015): Outer membrane usher protein
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
130 TOM1L2suppressor100.222118.380GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
131 TPD52L2protein found in more fusions100.27852.200TPD52 (PF04201, IPR007327): Tumour protein D52 family
132 TPM1protein found in more fusions110.37839.002Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
133 TPM2protein found in more fusions90.5009.867DASH_Spc19 (PF08287, IPR013251): Spc19
Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
134 TPM3oncoprotein90.39321.789Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
135 TPM3P4interactor21.0000NA
136 TRIP6interactor170.22880.096DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain
137 TSPAN3interactor100Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family
138 TTC1interactor160.37536.495TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
139 TTC9Cinteractor200.28987.490TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
140 TTLL12interactor150.44826.388TTL (PF03133, IPR004344): Tubulin-tyrosine ligase family
141 TUBB6interactor80.28615.454Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
142 TXNoncoprotein100.42218.835Thioredoxin (PF00085, IPR013766): Thioredoxin
143 TYMSinteractor100.48910.445Thymidylat_synt (PF00303, IPR000398): Thymidylate synthase
144 UBA2interactor190.28776.203ThiF (PF00899, IPR000594): ThiF family
UAE_UbL (PF14732, IPR028077): Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
145 UBA52interactor70.7141.680Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
146 UBA6interactor80.6078.050ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
147 UBE2Binteractor220.32474.697UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
148 UBE2Concoprotein230.36492.472UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
149 UBE2D1interactor200.368238.256UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
150 UBE2D2oncoprotein160.419154.989UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
151 UBE2L3interactor200.339224.782UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
152 UBE2V1interactor160.38345.177UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
153 UBE4Bsuppressor280.376334.560DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core
U-box (PF04564, IPR003613, SM00504): U-box domain
DUF4568 (PF15132, IPR027919): Domain of unknown function (DUF4568)
154 UBL7oncoprotein120.56112.195UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
155 UBQLN1protein found in more fusions260.283651.459Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
156 UBQLN4interactor230.303291.686CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
157 UBXN1interactor200.42757.627Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
158 UCHL3interactor190.41844.464Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
159 UFC1interactor160.40037.244UFC1 (PF08694, IPR014806): Ubiquitin-fold modifier-conjugating enzyme 1
160 UFM1interactor210.39596.901Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
161 USP34interactor270.336130.882Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUF3517 (PF12030, IPR021905): Domain of unknown function (DUF3517)
162 USP42interactor100TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
AP3D1 (PF06375): AP-3 complex subunit delta-1
163 USP9Xinteractor260.338137.886DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
164 VPS26Aprotein found in more fusions90.6079.821Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
165 VPS4Binteractor160.43353.837AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
166 WDR48suppressor40.5003.224WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337)
167 XPO1interactor210.195446.825CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
168 YAP1suppressor180.38664.189Bindin (PF02084, IPR000775): Bindin
WW (PF00397, IPR001202, SM00456): WW domain
GspL_C (PF12693, IPR025691): GspL periplasmic domain
FAM181 (PF15238, IPR029359): FAM181
169 ZC3H3interactor40.3339.076zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family
170 ZFYVE19interactor230.41167.714Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
171 ZNF165interactor100SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
172 ZNF444interactor21.0000FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
173 ZPR1interactor200.33761.603zf-ZPR1 (PF03367, IPR004457, SM00709): ZPR1 zinc-finger domain
174 ZRANB2interactor190.36868.690RRN3 (PF05327, IPR007991): RNA polymerase I specific transcription initiation factor RRN3
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
175 ZYXsuppressor140.35234.744DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
LIM (PF00412, IPR001781, SM00132): LIM domain
DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)

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