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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)131
The number (and %) of the onco-proteins39 (29.77 %)
The number (and %) of the tumor suppressors12 (9.16 %)
Total number of binary PPIs (saturation %)634 (7.45 %)
The number (and %) of affected PPIs132 (20.82 %)
The number of possible different fusions16
PPI diameter4
PPI radius2
The average degree of PPI9.023
Assortativity coefficient-0.4177
The network average Clustering coefficient0.489
The number (and %) of a zero Clustering coefficients12 (9.16 %)
The number (and %) of a zero Betweenness Centrality21 (16.03 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PCGF1,MGEA5 All fusions
Proteins found in more fusions TPM1 (see 2 fusions); HSP90AA1 (see 2 fusions); KDM2B (see 1 fusions); GSK3B (see 1 fusions); TPM3 (see 2 fusions); A2M (see 2 fusions); NTRK1/TPM3 (see 3 fusions); ERBB3 (see 2 fusions); EBF1 (see 1 fusions); EZH2 (see 1 fusions); CDC37 (see 2 fusions); DDB1 (see 2 fusions); RING1 (see 1 fusions); IBTK (see 2 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PCGF1parental protein1030.0628262.131zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
2 MGEA5parental protein290.1431648.956NAGidase (PF07555, IPR011496): beta-N-acetylglucosaminidase
3 A2Mprotein found in more fusions70.7338.499A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
MP (PF01107, IPR028919): Viral movement protein (MP)
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
4 ACACBinteractor60.33324.556ACC_central (PF08326, IPR013537): Acetyl-CoA carboxylase, central region
Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Carboxyl_trans (PF01039, IPR000022): Carboxyl transferase domain
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
5 AKAP9oncoprotein50.8000.533ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
ZYG-11_interact (PF05884, IPR008574): Interactor of ZYG-11
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Hema_stalk (PF08720, IPR014831): Influenza C hemagglutinin stalk
IncA (PF04156, IPR007285): IncA protein
Laminin_II (PF06009, IPR010307): Laminin Domain II
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
ApoO (PF09769, IPR019166): Apolipoprotein O
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Macoilin (PF09726, IPR019130): Transmembrane protein
PACT_coil_coil (PF10495, IPR019528): Pericentrin-AKAP-450 domain of centrosomal targeting protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
FlxA (PF14282, IPR025577): FlxA-like protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
6 ARID1Boncoprotein60.5335.224ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Presenilin (PF01080, IPR001108): Presenilin
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
DUF2235 (PF09994, IPR018712): Uncharacterized alpha/beta hydrolase domain (DUF2235)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa
Spt20 (PF12090, IPR021950): Spt20 family
7 ATG101interactor80.214116.061ATG101 (PF07855, IPR012445): Autophagy-related protein 101
8 ATG13oncoprotein21.0000ATG13 (PF10033, IPR018731): Autophagy-related protein 13
9 B9D2interactor40.6671.167B9-C2 (PF07162, IPR010796): Ciliary basal body-associated, B9 protein
10 BCORoncoprotein290.161294.927Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region
PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
11 BCORL1suppressor60.6674.379Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region
PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
12 BMI1oncoprotein220.314169.219zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
13 C1QTNF9oncoprotein100C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
14 CALCOCO2interactor50.500152.457bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
15 CAP1interactor61.0000CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
16 CARD14interactor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
ZapB (PF06005, IPR009252): Cell division protein ZapB
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
17 CBX6interactor70.76212.103Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
CBX7_C (PF17218): CBX family C-terminal motif
18 CBX7interactor110.56422.554Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
CBX7_C (PF17218): CBX family C-terminal motif
19 CBX8interactor150.462282.008Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
20 CCAR1suppressor205.480Cucumo_2B (PF03263, IPR004946): Cucumovirus protein 2B
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
IncA (PF04156, IPR007285): IncA protein
Presenilin (PF01080, IPR001108): Presenilin
SAP (PF02037, IPR003034, SM00513): SAP domain
FimP (PF09766, IPR019163): Fms-interacting protein
DBC1 (PF14443, IPR025954, SM01122): DBC1
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
S1-like (PF14444, IPR025223): S1-like
DUF4481 (PF14800, IPR028054): Domain of unknown function (DUF4481)
FAM176 (PF14851): FAM176 family
21 CDAN1interactor50.5001.091Codanin-1_C (PF15296, IPR028171): Codanin-1 C-terminus
22 CDC37protein found in more fusions150.231162.431CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
23 CDK12oncoprotein30.33311.557Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
Mem_trans (PF03547, IPR004776): Membrane transport protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SOBP (PF15279, IPR026092): Sine oculis-binding protein
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
24 CEP19interactor308.465CEP19 (PF14933, IPR029412): CEP19-like protein
25 CHMP4Binteractor40.6671.000Snf7 (PF03357, IPR005024): Snf7
26 CLIP1oncoprotein40.6670.108ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
CP12 (PF02672, IPR003823, SM01093): CP12 domain
DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
FliJ (PF02050, IPR012823): Flagellar FliJ protein
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
SlyX (PF04102, IPR007236): SlyX
ApoO (PF09769, IPR019166): Apolipoprotein O
Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Leu_zip (PF15294): Leucine zipper
CLIP1_ZNF (PF16641, IPR032108): CLIP1 zinc knuckle
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
27 CLPBinteractor21.0000AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
Torsin (PF06309, IPR010448): Torsin
ClpB_D2-small (PF10431, IPR019489, SM01086): C-terminal, D2-small domain, of ClpB protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_33 (PF13671): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
28 CRBNinteractor50.8000.108LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
29 CSNK2Binteractor180.235243.316CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
30 CYLDsuppressor100CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-HIT (PF04438, IPR007529): HIT zinc finger
CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured
31 DDB1protein found in more fusions140.38564.864CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
32 DIDO1suppressor31.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
SlyX (PF04102, IPR007236): SlyX
SPOC (PF07744, IPR012921): SPOC domain
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
33 DPPA2interactor31.0000SAP (PF02037, IPR003034, SM00513): SAP domain
DCR (PF14047, IPR025891): Dppa2/4 conserved region
Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates
34 DPPA4interactor420.104566.032Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family
DCR (PF14047, IPR025891): Dppa2/4 conserved region
Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates
35 EBF1oncoprotein31.0000TIG (PF01833, IPR002909): IPT/TIG domain
COE1_DBD (PF16422, IPR032200): Transcription factor COE1 DNA-binding domain
COE1_HLH (PF16423, IPR032201): Transcription factor COE1 helix-loop-helix domain
36 EEDsuppressor250.290178.889WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
37 ELAVL1oncoprotein250.149744.951RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
38 ELP3interactor40.33310.439Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
Radical_SAM (PF04055, IPR007197): Radical SAM superfamily
Radical_SAM_C (PF16199, IPR032432): Radical_SAM C-terminal domain
39 ERBB3oncoprotein70.40023.821Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
40 ERC1oncoprotein40.8330.045RBD-FIP (PF09457, IPR019018): FIP domain
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Cast (PF10174, IPR019323): RIM-binding protein of the cytomatrix active zone
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
41 ERCC8oncoprotein70.47614.663WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4859 (PF16151, IPR032339): Domain of unknown function (DUF4859)
42 EZH2suppressor120.41854.045CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
43 FABP5interactor40.6671.784Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
44 FKBP4interactor80.57126.045FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
45 FKBP5interactor90.61120.265FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
NuDC (PF16273, IPR032572): Nuclear distribution C domain
46 GPATCH8interactor30.6670.333G-patch (PF01585, IPR000467, SM00443): G-patch domain
Peptidase_S64 (PF08192, IPR012985): Peptidase family S64
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
Use1 (PF09753, IPR019150): Membrane fusion protein Use1
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SOBP (PF15279, IPR026092): Sine oculis-binding protein
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
47 GSK3Bsuppressor60.4008.882Pkinase (PF00069, IPR000719): Protein kinase domain
48 HIST1H2AGinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
49 HIST1H2AIinteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
50 HIST1H2AKinteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
51 HIST1H2ALinteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
52 HIST1H2AMinteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
53 HIST1H2BGoncoprotein60.46711.427Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
54 HIST1H3Ainteractor130.24270.408Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
55 HMGA1oncoprotein60.4007.940AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF2239 (PF09998, IPR018715): Uncharacterized protein conserved in bacteria (DUF2239)
56 HMGA2oncoprotein30.6670.250AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1639 (PF07797, IPR012438): Protein of unknown function (DUF1639)
57 HRGsuppressor40.6670.108Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
58 HSP90AA1oncoprotein170.325593.280HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
59 HSPA4interactor70.381132.150Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
60 IBTKprotein found in more fusions70.4673.478BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
61 ING4suppressor50.5000.917PHD (PF00628, IPR019787, SM00249): PHD-finger
SOGA (PF11365, IPR027881): Protein SOGA
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
62 ITPR3interactor40.6670.108DUF1041 (PF06292, IPR010439, SM01145): Domain of Unknown Function (DUF1041)
Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RYDR_ITPR (PF01365, IPR000699): RIH domain
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
63 KDM2Boncoprotein120.43623.281zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
F-box (PF00646, IPR001810, SM00256): F-box domain
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
Cupin_8 (PF13621): Cupin-like domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
MRI (PF15325, IPR028278): Modulator of retrovirus infection
PHD_4 (PF16866, IPR019787): PHD-finger
64 LACTB2interactor100E2_bind (PF08825, IPR014929): E2 binding domain
Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
Metallophos_3 (PF14582, IPR029461): Metallophosphoesterase, calcineurin superfamily
65 LETMD1interactor50.5000.587LETM1 (PF07766, IPR011685): LETM1-like protein
66 MAGED2interactor80.53630.521CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
MAGE (PF01454, IPR002190): MAGE family
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
67 MAST1interactor60.66716.648DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
68 MCM3interactor70.8571.268MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
69 MDC1suppressor110.382186.197FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
70 MLLT3oncoprotein31.0000Peptidase_S64 (PF08192, IPR012985): Peptidase family S64
YEATS (PF03366, IPR005033): YEATS family
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
NKAP (PF15692): NF-kappa-B-activating protein
BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
71 MRE11Aoncoprotein90.46420.756APG6 (PF04111, IPR007243): Autophagy protein Apg6
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
Mre11_DNA_bind (PF04152, IPR007281): Mre11 DNA-binding presumed domain
72 NAA50interactor50.5000.587Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
73 NANOGinteractor490.058963.050Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
74 NSFinteractor90.39321.174AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
ATPase (PF06745, IPR014774): KaiC
AAA_19 (PF13245): Part of AAA domain
75 NTRK1oncoprotein320.118909.352I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
76 OBFC1interactor100STN1_2 (PF09170, IPR015253): CST, Suppressor of cdc thirteen homolog, complex subunit STN1
RUN (PF02759, IPR004012, SM00593): RUN domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
Stn1 (PF10451, IPR018856): Telomere regulation protein Stn1
77 OGTinteractor50.6006.331TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41
TPR_19 (PF14559): Tetratricopeptide repeat
78 PATZ1oncoprotein31.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
79 PAXIP1interactor160.225433.890BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
80 PCGF5interactor130.57616.956DZR (PF12773, IPR025874): Double zinc ribbon
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
81 PCMT1interactor70.42921.429PCMT (PF01135, IPR000682): Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
82 PCMTD2interactor50.8000.108PCMT (PF01135, IPR000682): Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
SOCS_box (PF07525, IPR001496): SOCS box
83 PDCD7interactor40.33316.257PDCD7 (PF16021, IPR031974): Programmed cell death protein 7
84 PGAM1interactor40.50015.311His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
85 PHC2interactor130.57629.422SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-CGNR (PF11706, IPR021005): CGNR zinc finger
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
86 PITHD1interactor21.0000PITH (PF06201, IPR010400): PITH domain
87 POLE2interactor21.0000DNA_pol_E_B (PF04042, IPR007185): DNA polymerase alpha/epsilon subunit B
Dpoe2NT (PF12213, IPR024639): DNA polymerases epsilon N terminal
88 POU5F1oncoprotein560.0801305.618Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
89 PPP1R18interactor2012.030Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
Phostensin (PF13914, IPR025907): Phostensin PP1-binding and SH3-binding region
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
90 PPP2R3Ainteractor30.6670.045EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
DUF3924 (PF13062, IPR025038): Protein of unknown function (DUF3924)
DUF4116 (PF13475, IPR025197): Domain of unknown function (DUF4116)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
DUF4187 (PF13821, IPR025239): Domain of unknown function (DUF4187)
91 PPP6Cinteractor80.393106.672Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
92 PQBP1interactor21.0000WW (PF00397, IPR001202, SM00456): WW domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
93 PRAM1interactor80.321345.026hSH3 (PF14603, IPR029294): Helically-extended SH3 domain
94 PSEN2oncoprotein50.6677.870Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
Presenilin (PF01080, IPR001108): Presenilin
95 RAB13oncoprotein40.6670.108Ras (PF00071, IPR001806, SM00173): Ras family
96 RING1protein found in more fusions150.64812.598zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
97 RNF125interactor40.6670.667zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
98 RNF2interactor350.244574.228zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
99 RNF32interactor80.61921.577IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
100 RYBPinteractor130.53838.630DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
101 SAP18interactor100.31137.794SAP18 (PF06487, IPR010516): Sin3 associated polypeptide p18 (SAP18)
102 SASS6interactor50.7000.775CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
SAS-6_N (PF16531, IPR032396): Centriolar protein SAS N-terminal
103 SATB2interactor40.33314.769CUT (PF02376, IPR003350, SM01109): CUT domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB
CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB
104 SIN3Aoncoprotein110.273220.056Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
105 SIPA1L2interactor40.6670.108IncA (PF04156, IPR007285): IncA protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
SPAR_C (PF11881, IPR021818): C-terminal domain of SPAR protein
106 SKP1oncoprotein110.49155.650Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
107 SMARCC2interactor120.40976.028GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
108 SPECC1oncoprotein50.7000.477CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Fez1 (PF06818): Fez1
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
TSNAXIP1_N (PF15739, IPR032755): Translin-associated factor X-interacting N-terminus
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
SHE3 (PF17078, IPR031398): SWI5-dependent HO expression protein 3
109 SRRTinteractor70.38131.588ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3546 (PF12066, IPR021933): Domain of unknown function (DUF3546)
DUF4187 (PF13821, IPR025239): Domain of unknown function (DUF4187)
110 SSBP3oncoprotein30.6670.511SSDP (PF04503): Single-stranded DNA binding protein, SSDP
111 SUZ12suppressor180.368109.608DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
112 TCEB1oncoprotein80.4649.962Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
113 TCERG1interactor60.60011.959FF (PF01846, IPR002713, SM00441): FF domain
WW (PF00397, IPR001202, SM00456): WW domain
Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
FAM150 (PF15129, IPR029364): FAM150 family
114 TIAL1interactor40.5000.779RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
115 TOR3Ainteractor40.6670.108DUF433 (PF04255, IPR007367): Protein of unknown function (DUF433)
Torsin (PF06309, IPR010448): Torsin
AAA_22 (PF13401, IPR003593): AAA domain
116 TP53BP1suppressor90.50013.20053-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
117 TPM1protein found in more fusions60.6008.988Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
118 TPM3oncoprotein140.423113.234Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
119 TRIM55interactor50.6671.190Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
NABP (PF07990, IPR012940): Nucleic acid binding protein NABP
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
120 TUBGCP2interactor40.6678.273Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
121 TXNoncoprotein60.40016.196Thioredoxin (PF00085, IPR013766): Thioredoxin
122 UBE2D3interactor100.50044.036UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
123 UBE2Uinteractor30.6671.411UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
efb-c (PF12199, IPR021033): Extracellular fibrinogen binding protein C terminal
TMEM154 (PF15102, IPR028064): TMEM154 protein family
124 UPF1interactor110.364155.852UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain)
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
125 USP34interactor50.8000.108Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUF3517 (PF12030, IPR021905): Domain of unknown function (DUF3517)
126 USP42interactor50.5000.587TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
AP3D1 (PF06375): AP-3 complex subunit delta-1
127 USP7oncoprotein230.281403.086MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
128 USP9Xinteractor60.53322.565DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
129 YAF2interactor100.6226.907DUF460 (PF04312, IPR007408): Protein of unknown function (DUF460)
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Exo5 (PF09810, IPR019190): Exonuclease V - a 5' deoxyribonuclease
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
YAF2_RYBP (PF17219): Yaf2/RYBP C-terminal binding motif
130 ZGPATinteractor50.5002.441Agenet (PF05641, IPR008395, SM00743): Agenet domain
G-patch (PF01585, IPR000467, SM00443): G-patch domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
131 ZNF157interactor40.6670.108KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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