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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins POLQ, SLC30A7 (from a repository: Sat Jul 27 10:34:06 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins4 (22.22 %)
The number (and %) of the tumor suppressors1 (5.56 %)
Total number of binary PPIs (saturation %)19 (12.42 %)
The number (and %) of affected PPIs16 (84.21 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI1.889
Assortativity coefficient-0.2919
The network average Clustering coefficient0.112
The number (and %) of a zero Clustering coefficients15 (83.33 %)
The number (and %) of a zero Betweenness Centrality17 (94.44 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: POLQ,SLC30A7 All fusions
Proteins found in more fusions CD40 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 POLQparental protein100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DNA_pol_A (PF00476, IPR001098, SM00482): DNA polymerase family A
DUF4332 (PF14229, IPR025567): Domain of unknown function (DUF4332)
2 SLC30A7parental protein150.010208.000Cation_efflux (PF01545, IPR002524): Cation efflux family
3 AP2S1interactor100Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
4 B3GNT3interactor100Galactosyl_T (PF01762, IPR002659): Galactosyltransferase
5 CD40protein found in more fusions200Glycophorin_A (PF01102, IPR001195): Glycophorin A
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
6 CHRNA9interactor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
7 CLPSL1interactor100Toxin_3 (PF00537, IPR002061): Scorpion toxin-like domain
8 ELAVL1oncoprotein200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
9 KATNA1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ABC_tran (PF00005, IPR003439): ABC transporter
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
AAA_22 (PF13401, IPR003593): AAA domain
10 LPAR1oncoprotein21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
11 LYPD3oncoprotein21.0000DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753)
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
12 LYPD6interactor100UPAR_LY6_2 (PF16975): Ly6/PLAUR domain-containing protein 6, Lypd6
13 MRPL1interactor100CUB_2 (PF02408, IPR003366): CUB-like domain
Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
14 P2RY12interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
15 RIC3interactor100CHASE3 (PF05227, IPR007891): CHASE3 domain
RIC3 (PF15361, IPR032763): Resistance to inhibitors of cholinesterase homologue 3
16 SPINT2suppressor100Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
17 TCTN3interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
18 WBP1interactor100WBP-1 (PF11669, IPR021684): WW domain-binding protein 1

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