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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ELL, CERS1 (from a repository: Sun Oct 13 03:00:30 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)34
The number (and %) of the onco-proteins13 (38.24 %)
The number (and %) of the tumor suppressors5 (14.71 %)
Total number of binary PPIs (saturation %)115 (20.50 %)
The number (and %) of affected PPIs32 (27.83 %)
The number of possible different fusions11
PPI diameter2
PPI radiusinf
The average degree of PPI6.059
Assortativity coefficient-0.2301
The network average Clustering coefficient0.611
The number (and %) of a zero Clustering coefficients4 (11.76 %)
The number (and %) of a zero Betweenness Centrality11 (32.35 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CERS1,ELL All fusions
Proteins found in more fusions KMT2A (see 15 fusions); OFD1 (see 5 fusions); HUWE1 (see 4 fusions); MCM2 (see 1 fusions); TP53 (see 3 fusions); UBC (see 7 fusions); CDK9 (see 2 fusions); MLLT1/KMT2A (see 19 fusions); ELL/KMT2A (see 9 fusions); MLLT3/KMT2A (see 22 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CERS1parental protein202.000TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
2 ELLparental protein300.163563.250Occludin_ELL (PF07303, IPR010844): Occludin homology domain
ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
3 AFF4oncoprotein110.58214.417AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
4 ASPMoncoprotein30.6670.500CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RST (PF12174, IPR022003): RCD1-SRO-TAF4 (RST) plant domain
ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
5 CDK9protein found in more fusions100.6676.800Pkinase (PF00069, IPR000719): Protein kinase domain
6 CTR9interactor41.0000DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
Pap_E4 (PF02711, IPR003861): E4 protein
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175)
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
7 DENND2Dsuppressor31.0000dDENN (PF03455, IPR005112, SM00801): dDENN domain
DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain
uDENN (PF03456, IPR005113, SM00800): uDENN domain
8 DYNLL1interactor50.5002.333Dynein_light (PF01221, IPR001372): Dynein light chain type 1
9 EAF1suppressor120.50023.550Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Peroxin-3 (PF04882, IPR006966): Peroxin-3
EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
10 EAF2suppressor60.7332.250Paf1 (PF03985, IPR007133): Paf1
EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
11 ELL3interactor90.5289.133Occludin_ELL (PF07303, IPR010844): Occludin homology domain
ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
TEX19 (PF15553, IPR029093): Testis-expressed protein 19
12 FGFR1OP2oncoprotein40.8330.667Cauli_AT (PF03233, IPR004917): Aphid transmission protein
DUF837 (PF05769, IPR008555): Protein of unknown function (DUF837)
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
13 HUWE1oncoprotein60.7002.333BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
14 ICE1interactor100.37823.083DivIC (PF04977, IPR007060): Septum formation initiator
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
SlyX (PF04102, IPR007236): SlyX
15 ICE2interactor100.40021.750NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
16 KMT2Aoncoprotein80.7143.167AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus
FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SET (PF00856, IPR001214, SM00317): SET domain
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
17 MAPK6oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
18 MCM2oncoprotein70.4677.333AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
19 MED26interactor90.6396.633Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal
Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
20 MLLT1oncoprotein80.8211.783DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Peptidase_S64 (PF08192, IPR012985): Peptidase family S64
YEATS (PF03366, IPR005033): YEATS family
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
21 MLLT3oncoprotein90.6945.783Peptidase_S64 (PF08192, IPR012985): Peptidase family S64
YEATS (PF03366, IPR005033): YEATS family
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
NKAP (PF15692): NF-kappa-B-activating protein
BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
22 NCBP2interactor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
23 OFD1protein found in more fusions60.5004.000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
GrpE (PF01025, IPR000740): GrpE
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372)
LisH_2 (PF16045, IPR006594): LisH
24 SIKE1interactor31.0000DUF837 (PF05769, IPR008555): Protein of unknown function (DUF837)
Rho_Binding (PF08912, IPR015008): Rho Binding
25 SIRT2suppressor100SIR2 (PF02146, IPR003000): Sir2 family
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
26 SNF8interactor31.0000EAP30 (PF04157, IPR007286): EAP30/Vps36 family
27 SNRPA1interactor50.6004.000LRR_9 (PF14580): Leucine-rich repeat
28 TCTN3interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
29 TFPToncoprotein41.0000GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
30 TP53suppressor100.30621.900DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
31 UBCprotein found in more fusions60.7002.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
32 USPL1interactor21.0000zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
Peptidase_C98 (PF15499, IPR028890): Ubiquitin-specific peptidase-like, SUMO isopeptidase
DUF4650 (PF15509, IPR029388): Domain of unknown function (DUF4650)
33 VWA9interactor21.0000VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
34 ZHX1interactor50.6671.333Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez
zf-C2H2_4 (PF13894): C2H2-type zinc finger
TerB_C (PF15615, IPR028932): TerB-C domain

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