Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins ITCH, MTX2 (from a repository: Thu Jul 9 12:20:34 2020)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 190 The number (and %) of the onco-proteins 57 (30.00 %) The number (and %) of the tumor suppressors 33 (17.37 %) Total number of binary PPIs (saturation %) 1168 (6.51 %) The number (and %) of affected PPIs 189 (16.18 %) The number of possible different fusions 47 PPI diameter 5 PPI radius 3 The average degree of PPI 11.389 Assortativity coefficient -0.2328 The network average Clustering coefficient 0.430 The number (and %) of a zero Clustering coefficients 7 (3.68 %) The number (and %) of a zero Betweenness Centrality 16 (8.42 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: MTX2,ITCH	All fusions
Proteins found in more fusions	UBE2G1 (see 1 fusions); CBL (see 1 fusions); CSNK2A1/ELAVL1 (see 1 fusions); CUL3 (see 1 fusions); GRB2 (see 1 fusions); FYN (see 1 fusions); DVL3 (see 1 fusions); UBA1 (see 2 fusions); WWP1 (see 1 fusions); UBE2D2 (see 2 fusions); EWSR1 (see 2 fusions); TXNIP (see 2 fusions); IMMT (see 4 fusions); HTT (see 1 fusions); SMARCC1 (see 2 fusions); IKBKB (see 2 fusions); NUDT21 (see 2 fusions); PCNA (see 1 fusions); UBE2E1 (see 3 fusions); UBC (see 1 fusions); LRRK2 (see 1 fusions); RASSF5 (see 2 fusions); SNX9 (see 2 fusions); TP53 (see 3 fusions); TRAF6 (see 1 fusions); URI1 (see 3 fusions); RNF11 (see 1 fusions); HNRNPUL1 (see 1 fusions); SH3GL2 (see 1 fusions); SFN (see 1 fusions); KPNB1 (see 2 fusions); PABPC1 (see 2 fusions); NCOA1 (see 2 fusions); HNRNPL (see 2 fusions); PCBP2 (see 3 fusions); SF1 (see 1 fusions); POLR2E (see 2 fusions); RIPK1 (see 1 fusions); EGFR (see 2 fusions); NEDD9 (see 1 fusions); POLR2A (see 2 fusions); CSNK2A1 (see 1 fusions); ATN1 (see 1 fusions); MAP3K7 (see 7 fusions); DTX3L (see 2 fusions); SMAD3 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	MTX2	parental protein	25	0.117	1100.393	Tom37 (PF10568, IPR019564): Outer mitochondrial membrane transport complex protein GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
2	ITCH	parental protein	164	0.057	20135.387	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
3	ADRB2	interactor	21	0.179	572.159	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4	AMOT	oncoprotein	9	0.429	9.033	FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP) Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162) Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
5	APOOL	interactor	7	0.667	3.067	ApoO (PF09769, IPR019166): Apolipoprotein O
6	ARHGEF7	interactor	5	0.700	2.813	Borrelia_lipo_1 (PF05714, IPR008421): Borrelia burgdorferi virulent strain associated lipoprotein CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_2 (PF07653, IPR011511): Variant SH3 domain RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7 RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7
7	ARID1A	suppressor	13	0.615	16.686	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family YscJ_FliF_C (PF08345, IPR013556): Flagellar M-ring protein C-terminal TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
8	ARRB1	interactor	21	0.276	135.954	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
9	ARRB2	interactor	23	0.281	190.310	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
10	ARRDC1	interactor	6	0.333	5.888	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
11	ARRDC3	interactor	8	0.464	7.565	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
12	ARRDC4	interactor	4	0.833	0.517	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
13	ATN1	protein found in more fusions	7	0.667	1.987	Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
14	ATXN3	interactor	10	0.361	16.158	Josephin (PF02099, IPR006155): Josephin UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
15	BECN1	suppressor	5	0.667	2.036	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
16	BID	oncoprotein	6	0.500	7.694	BID (PF06393, IPR010479): BH3 interacting domain (BID)
17	BIN1	suppressor	5	0.500	3.872	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
18	C19orf70	interactor	7	0.524	9.466	QIL1 (PF15884, IPR026769): Protein QIL1
19	CAV1	suppressor	15	0.190	202.739	Caveolin (PF01146, IPR001612): Caveolin
20	CBL	suppressor	24	0.198	212.969	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
21	CBLC	oncoprotein	9	0.472	16.199	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
22	CCDC155	interactor	1	0	0	CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein EF-hand_9 (PF14658): EF-hand domain KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
23	CD244	interactor	3	0.333	21.782	Receptor_2B4 (PF11465, IPR024303): Natural killer cell receptor 2B4 WBP-1 (PF11669, IPR021684): WW domain-binding protein 1 Ig_2 (PF13895, IPR007110): Immunoglobulin domain
24	CDC34	oncoprotein	6	0.900	0.550	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
25	CEP120	interactor	5	0.100	46.193	C2 (PF00168, IPR000008, SM00239): C2 domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) DUF3668 (PF12416, IPR022136): Cep120 protein DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
26	CFLAR	oncoprotein	7	0.533	5.506	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
27	CHCHD3	interactor	9	0.389	208.771	DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737) eIF3g (PF12353, IPR024675): Eukaryotic translation initiation factor 3 subunit G
28	CHCHD6	interactor	5	0.400	103.281	CHCH (PF06747, IPR010625): CHCH domain DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
29	COL18A1	oncoprotein	2	1.000	0	Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) DUF959 (PF06121, IPR010363): Domain of Unknown Function (DUF959) Endostatin (PF06482, IPR010515): Collagenase NC10 and Endostatin Fz (PF01392, IPR020067, SM00063): Fz domain Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
30	CPSF6	interactor	13	0.410	24.641	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1
31	CPSF7	interactor	11	0.345	25.482	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1
32	CSNK2A1	oncoprotein	23	0.281	139.932	Pkinase (PF00069, IPR000719): Protein kinase domain
33	CUL3	protein found in more fusions	53	0.113	1481.987	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
34	CXCR4	interactor	3	0.667	0.889	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain CXCR4_N (PF12109, IPR022726): CXCR4 Chemokine receptor N terminal
35	CYLD	suppressor	9	0.444	16.913	CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-HIT (PF04438, IPR007529): HIT zinc finger CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured
36	DAZAP1	interactor	7	0.619	3.077	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
37	DTX1	interactor	9	0.429	6.330	WWE (PF02825, IPR004170, SM00678): WWE domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger PRIMA1 (PF16101): Proline-rich membrane anchor 1
38	DTX3L	protein found in more fusions	12	0.327	25.118	KH_1 (PF00013, IPR004088, SM00322): KH domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
39	DVL1	interactor	14	0.372	35.726	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
40	DVL2	interactor	14	0.410	37.686	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
41	DVL3	protein found in more fusions	9	0.536	58.183	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
42	EGFR	oncoprotein	46	0.116	1814.649	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
43	EIF2B4	interactor	2	0	7.835	IF-2B (PF01008, IPR000649): Initiation factor 2 subunit family Mpp10 (PF04006, IPR007151): Mpp10 protein
44	ELAVL1	oncoprotein	42	0.133	1231.285	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
45	ERBB4	suppressor	11	0.400	9.819	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
46	EWSR1	oncoprotein	24	0.253	161.298	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
47	FAM189A2	interactor	7	0.381	7.900	CD20 (PF04103, IPR007237): CD20-like family
48	FAM189B	interactor	5	0.600	1.497	CD20 (PF04103, IPR007237): CD20-like family TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
49	FBXL15	interactor	2	1.000	0	LRV (PF01816, IPR004830): Leucine rich repeat variant F-box (PF00646, IPR001810, SM00256): F-box domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat
50	FYN	oncoprotein	10	0.194	256.294	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
51	GBA	interactor	4	0.500	2.333	Glyco_hydro_30 (PF02055, IPR001139): Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C (PF17189): Glycosyl hydrolase family 30 beta sandwich domain
52	GGA3	interactor	6	0.533	8.308	Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal GAT (PF03127, IPR004152): GAT domain VHS (PF00790, IPR002014, SM00288): VHS domain
53	GLI1	suppressor	7	0.429	103.164	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
54	GLIS3	interactor	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
55	GNAI2	oncoprotein	4	0.500	5.602	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
56	GRAP2	interactor	5	0.500	27.460	NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal SH2 (PF00017, IPR000980, SM00252): SH2 domain DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
57	GRB2	oncoprotein	23	0.229	203.059	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
58	GSN	suppressor	6	0.667	3.757	Gelsolin (PF00626, IPR007123): Gelsolin repeat
59	HDAC6	oncoprotein	18	0.228	95.220	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
60	HGS	interactor	24	0.199	311.385	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate PIEZO (PF15917, IPR031805): Piezo
61	HNRNPL	protein found in more fusions	11	0.511	24.166	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
62	HNRNPR	interactor	12	0.258	157.425	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
63	HNRNPUL1	protein found in more fusions	9	0.429	115.737	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
64	HTT	protein found in more fusions	11	0.311	37.860	HEAT (PF02985, IPR000357): HEAT repeat SPX (PF03105, IPR004331): SPX domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3652 (PF12372, IPR024613): Huntingtin protein region Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
65	IKBKB	protein found in more fusions	15	0.275	66.952	FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
66	IMMT	protein found in more fusions	13	0.197	259.067	Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
67	ITSN1	interactor	7	0.467	5.631	C2 (PF00168, IPR000008, SM00239): C2 domain VIT1 (PF01988, IPR008217): VIT family DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) SH3_9 (PF14604, IPR001452): Variant SH3 domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748) INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region PH_13 (PF16652, IPR001849): Pleckstrin homology domain
68	JUN	oncoprotein	17	0.342	46.444	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
69	KLF10	suppressor	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain AAA_33 (PF13671): AAA domain
70	KPNA2	interactor	11	0.309	125.724	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
71	KPNB1	protein found in more fusions	16	0.314	69.420	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat
72	KRAS	oncoprotein	10	0.083	123.114	Ras (PF00071, IPR001806, SM00173): Ras family
73	LAPTM5	oncoprotein	6	0.600	3.979	Mtp (PF03821, IPR004687): Golgi 4-transmembrane spanning transporter
74	LATS1	suppressor	8	0.464	12.447	Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6 Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
75	LDLRAD3	interactor	2	1.000	0	DUF1668 (PF07893, IPR012871): Protein of unknown function (DUF1668) Opy2 (PF09463, IPR018571): Opy2 protein Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A RCR (PF12273, IPR020999): Chitin synthesis regulation, resistance to Congo red
76	LDLRAD4	interactor	7	0.476	5.724	Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615)
77	LITAF	suppressor	5	0.500	3.199	zf-LITAF-like (PF10601, IPR006629, SM00714): LITAF-like zinc ribbon domain DUF3824 (PF12868, IPR024436): Domain of unknwon function (DUF3824)
78	LRRK2	oncoprotein	11	0.244	41.763	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
79	MAP2K4	suppressor	9	0.536	9.837	Pkinase (PF00069, IPR000719): Protein kinase domain
80	MAP3K7	oncoprotein	17	0.325	56.711	Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
81	MAPK8	oncoprotein	14	0.321	50.485	DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530) Pkinase (PF00069, IPR000719): Protein kinase domain
82	MAVS	interactor	7	0.600	4.723	Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat CARD_2 (PF16739, IPR031964): Caspase recruitment domain
83	MDM2	oncoprotein	29	0.188	260.151	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
84	MGRN1	interactor	9	0.278	18.596	zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
85	MINOS1	interactor	6	0.533	17.723	DUF543 (PF04418, IPR007512): Domain of unknown function (DUF543)
86	MLANA	interactor	1	0	0	MLANA (PF14991, IPR029242): Protein melan-A
87	MMGT1	interactor	9	0.306	89.500	MMgT (PF10270, IPR018937): Membrane magnesium transporter
88	MOV10	interactor	22	0.121	446.119	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
89	N4BP1	interactor	3	1.000	0	Enterotoxin_b (PF01376, IPR001835): Heat-labile enterotoxin beta chain RNase_Zc3h12a (PF11977, IPR021869): Zc3h12a-like Ribonuclease NYN domain
90	NCOA1	oncoprotein	11	0.444	20.765	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
91	NDFIP1	interactor	7	0.381	21.300	DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370) WBP-1 (PF11669, IPR021684): WW domain-binding protein 1 Comm (PF15957, IPR031878): Commissureless
92	NDFIP2	interactor	4	0.500	4.112	DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370)
93	NDUFA4	interactor	9	0.286	63.837	B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
94	NEDD9	protein found in more fusions	5	0.667	2.786	Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513) SH3_9 (PF14604, IPR001452): Variant SH3 domain
95	NFE2	interactor	4	0.667	0.500	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor Peptidase_Mx (PF15887, IPR031321): Putative zinc-binding metallo-peptidase
96	NOTCH1	suppressor	16	0.248	44.559	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
97	NUDT21	protein found in more fusions	7	0.733	2.168	NUDIX_2 (PF13869, IPR016706): Nucleotide hydrolase
98	NUMB	suppressor	6	0.600	6.895	NumbF (PF06311, IPR010449): NUMB domain PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
99	OCLN	interactor	4	0.500	2.713	MARVEL (PF01284, IPR008253): Membrane-associating domain Occludin_ELL (PF07303, IPR010844): Occludin homology domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
100	PABPC1	oncoprotein	12	0.400	29.502	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain YflT (PF11181, IPR025889): Heat induced stress protein YflT
101	PACSIN1	interactor	3	1.000	0	FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605) DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446) SH3_9 (PF14604, IPR001452): Variant SH3 domain NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
102	PCBP2	protein found in more fusions	11	0.422	37.073	Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein KH_2 (PF07650, IPR004044): KH domain KH_1 (PF00013, IPR004088, SM00322): KH domain
103	PCNA	oncoprotein	12	0.382	20.117	PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
104	PDCD6IP	interactor	14	0.295	56.904	BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
105	PHB	suppressor	10	0.289	178.575	Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
106	PHB2	interactor	6	0.533	27.125	DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605) Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
107	PLEKHB2	interactor	2	1.000	0	PH (PF00169, IPR001849, SM00233): PH domain
108	POLR2A	protein found in more fusions	19	0.294	128.474	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
109	POLR2B	interactor	9	0.667	29.940	RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 (PF04566, IPR007646): RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 (PF04567, IPR007647): RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7
110	POLR2C	interactor	13	0.439	64.136	RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
111	POLR2E	protein found in more fusions	12	0.545	18.746	RNA_pol_Rpb5_C (PF01191, IPR000783): RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N (PF03871, IPR005571): RNA polymerase Rpb5, N-terminal domain
112	POU5F1	oncoprotein	7	0.400	45.756	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
113	PPP1CA	suppressor	18	0.190	248.929	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
114	PRKACA	interactor	8	0.286	171.008	Pkinase (PF00069, IPR000719): Protein kinase domain
115	PTCH1	suppressor	6	0.467	12.896	Patched (PF02460, IPR003392): Patched family
116	RASSF5	suppressor	5	0.333	19.107	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
117	RIPK1	protein found in more fusions	12	0.345	38.929	Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif
118	RNF11	protein found in more fusions	18	0.279	69.549	zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
119	RPAP2	interactor	8	0.500	54.647	NAD_Gly3P_dh_N (PF01210, IPR011128): NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus RPAP2_Rtr1 (PF04181, IPR007308): Rtr1/RPAP2 family SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
120	RPAP3	interactor	9	0.694	9.746	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3 Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
121	SAMM50	interactor	8	0.429	111.125	Bac_surface_Ag (PF01103, IPR000184): Surface antigen POTRA (PF07244, IPR010827): Surface antigen variable number repeat
122	SCAMP3	interactor	5	0.600	6.659	SCAMP (PF04144, IPR007273): SCAMP family
123	SCNN1A	interactor	5	0.500	2.963	ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
124	SCNN1B	oncoprotein	3	1.000	0	ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
125	SF1	protein found in more fusions	9	0.429	10.388	UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181) zf-CCHC (PF00098, IPR001878): Zinc knuckle KH_1 (PF00013, IPR004088, SM00322): KH domain RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
126	SFN	suppressor	11	0.422	25.397	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
127	SGK3	interactor	1	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain PX (PF00787, IPR001683, SM00312): PX domain
128	SH3GL2	oncoprotein	7	0.600	7.292	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_2 (PF07653, IPR011511): Variant SH3 domain
129	SH3GLB1	suppressor	3	1.000	0	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
130	SLC1A5	interactor	4	0.500	0.929	SDF (PF00375, IPR001991): Sodium:dicarboxylate symporter family
131	SLC25A3	interactor	7	0.286	124.661	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
132	SLC3A2	interactor	5	0.400	8.640	Alpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain DUF3459 (PF11941, IPR022567): Domain of unknown function (DUF3459) SLC3A2_N (PF16028, IPR031984): Solute carrier family 3 member 2 N-terminus
133	SMAD2	suppressor	23	0.264	215.436	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
134	SMAD3	oncoprotein	27	0.249	152.262	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
135	SMAD6	interactor	10	0.489	16.323	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
136	SMAD7	interactor	15	0.362	36.124	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
137	SMARCC1	suppressor	18	0.478	42.525	SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF2618 (PF10940, IPR021237): Protein of unknown function (DUF2618) PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
138	SMARCC2	interactor	20	0.332	105.956	GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain SWIRM (PF04433, IPR007526): SWIRM domain DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
139	SMARCE1	interactor	11	0.582	13.224	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) GCN5L1 (PF06320, IPR009395): GCN5-like protein 1 (GCN5L1) Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
140	SNX18	interactor	5	0.600	2.196	PX (PF00787, IPR001683, SM00312): PX domain BAR_3_WASP_bdg (PF10456, IPR019497): WASP-binding domain of Sorting nexin protein SH3_9 (PF14604, IPR001452): Variant SH3 domain
141	SNX9	protein found in more fusions	4	0.667	0.251	PX (PF00787, IPR001683, SM00312): PX domain BAR_3_WASP_bdg (PF10456, IPR019497): WASP-binding domain of Sorting nexin protein SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
142	SPG20	interactor	5	0.600	1.537	MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain Senescence (PF06911, IPR009686): Senescence-associated protein
143	STAM	interactor	8	0.429	22.413	GAT (PF03127, IPR004152): GAT domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
144	STAM2	interactor	15	0.314	76.638	GAT (PF03127, IPR004152): GAT domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
145	TAB1	interactor	14	0.286	68.866	PP2C (PF00481, IPR001932): Protein phosphatase 2C
146	TADA2A	interactor	7	0.143	55.646	SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
147	TAX1BP1	interactor	7	0.476	9.936	CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain PolyA_pol (PF01743, IPR002646): Poly A polymerase head domain Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 zf-C2H2_4 (PF13894): C2H2-type zinc finger PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
148	TGFBR1	oncoprotein	12	0.424	31.537	Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain Pkinase (PF00069, IPR000719): Protein kinase domain TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
149	TMEM171	interactor	3	0.667	1.249	TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
150	TMEM255A	interactor	2	1.000	0	FAM70 (PF14967, IPR028014): FAM70 protein
151	TMEM51	interactor	2	1.000	0	WBP-1 (PF11669, IPR021684): WW domain-binding protein 1 TMEM51 (PF15345, IPR029265): Transmembrane protein 51
152	TMEM92	interactor	3	0.667	1.169	WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
153	TNFRSF10B	suppressor	9	0.417	21.580	Death (PF00531, IPR000488, SM00005): Death domain RskA (PF10099, IPR018764): Anti-sigma-K factor rskA TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
154	TOLLIP	interactor	10	0.389	19.401	C2 (PF00168, IPR000008, SM00239): C2 domain CUE (PF02845, IPR003892, SM00546): CUE domain
155	TP53	suppressor	42	0.156	904.822	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
156	TP53BP2	suppressor	11	0.273	91.000	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Erp_C (PF06780, IPR009618): Erp protein C-terminus SlyX (PF04102, IPR007236): SlyX SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
157	TP63	suppressor	13	0.364	32.108	Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
158	TP73	suppressor	8	0.476	6.405	P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
159	TPD52	oncoprotein	5	0.333	11.392	TPD52 (PF04201, IPR007327): Tumour protein D52 family
160	TRAF6	protein found in more fusions	25	0.199	224.299	SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
161	TRAK2	interactor	2	0	11.002	ZapB (PF06005, IPR009252): Cell division protein ZapB HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region Milton (PF12448, IPR022154): Kinesin associated protein
162	TRPV4	interactor	3	0.667	1.028	Ion_trans (PF00520, IPR005821): Ion transport protein Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
163	TXNIP	suppressor	4	1.000	0	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
164	UBA1	protein found in more fusions	19	0.275	100.227	ThiF (PF00899, IPR000594): ThiF family E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
165	UBA6	interactor	8	0.571	4.700	ThiF (PF00899, IPR000594): ThiF family E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
166	UBAP2	interactor	4	0.667	0.662	Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) CUE (PF02845, IPR003892, SM00546): CUE domain HlyE (PF06109, IPR027018): Haemolysin E (HlyE) MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein DUF3697 (PF12478, IPR022166): Ubiquitin-associated protein 2 UBA_4 (PF14555): UBA-like domain
167	UBAP2L	interactor	6	0.600	5.533	CUE (PF02845, IPR003892, SM00546): CUE domain DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch DUF3697 (PF12478, IPR022166): Ubiquitin-associated protein 2 UBA_4 (PF14555): UBA-like domain Comm (PF15957, IPR031878): Commissureless
168	UBC	protein found in more fusions	57	0.141	1889.447	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
169	UBE2D1	interactor	21	0.289	106.509	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
170	UBE2D2	oncoprotein	20	0.374	51.714	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
171	UBE2D3	interactor	19	0.261	56.799	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
172	UBE2E1	protein found in more fusions	10	0.278	11.867	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
173	UBE2E3	interactor	9	0.429	8.697	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
174	UBE2G1	protein found in more fusions	4	0.667	0.540	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
175	UBE2J2	interactor	4	0.667	1.318	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
176	UBE2K	interactor	10	0.444	19.639	UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
177	UBE2L3	interactor	22	0.238	200.364	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
178	URI1	protein found in more fusions	7	0.533	27.316	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein Prefoldin (PF02996, IPR004127): Prefoldin subunit DUF3835 (PF12927, IPR024325): Domain of unknown function (DUF3835) SCAPER_N (PF16501, IPR032446): S phase cyclin A-associated protein in the endoplasmic reticulum
179	USP12	suppressor	5	0.600	2.675	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
180	USP13	interactor	8	0.464	18.934	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
181	USP5	interactor	10	0.356	23.212	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
182	USP9X	interactor	12	0.424	25.746	DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722) UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
183	VDAC2	interactor	8	0.464	64.261	Porin_3 (PF01459, IPR027246): Eukaryotic porin
184	WBP1	interactor	4	0.500	0.433	WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
185	WBP2	interactor	4	0.500	0.433	GRAM (PF02893, IPR004182, SM00568): GRAM domain Vps36_ESCRT-II (PF11605, IPR021648): Vacuolar protein sorting protein 36 Vps36
186	WDR48	suppressor	7	0.619	5.154	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337)
187	WWOX	suppressor	39	0.132	641.652	adh_short (PF00106, IPR002198): short chain dehydrogenase WW (PF00397, IPR001202, SM00456): WW domain
188	WWP1	oncoprotein	37	0.106	537.417	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
189	YAP1	suppressor	28	0.135	356.938	Bindin (PF02084, IPR000775): Bindin WW (PF00397, IPR001202, SM00456): WW domain GspL_C (PF12693, IPR025691): GspL periplasmic domain FAM181 (PF15238, IPR029359): FAM181
190	YWHAQ	interactor	16	0.158	328.338	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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