1 |
MTX2 | parental protein | 25 | 0.117 | 1100.393 | Tom37 (PF10568, IPR019564): Outer mitochondrial membrane transport complex protein GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain |
2 |
ITCH | parental protein | 164 | 0.057 | 20135.387 | C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
3 |
ADRB2 | interactor | 21 | 0.179 | 572.159 | 7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) |
4 |
AMOT | oncoprotein | 9 | 0.429 | 9.033 | FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP) Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162) Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3 |
5 |
APOOL | interactor | 7 | 0.667 | 3.067 | ApoO (PF09769, IPR019166): Apolipoprotein O |
6 |
ARHGEF7 | interactor | 5 | 0.700 | 2.813 | Borrelia_lipo_1 (PF05714, IPR008421): Borrelia burgdorferi virulent strain associated lipoprotein CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_2 (PF07653, IPR011511): Variant SH3 domain RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7 RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7 |
7 |
ARID1A | suppressor | 13 | 0.615 | 16.686 | ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family YscJ_FliF_C (PF08345, IPR013556): Flagellar M-ring protein C-terminal TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail |
8 |
ARRB1 | interactor | 21 | 0.276 | 135.954 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
9 |
ARRB2 | interactor | 23 | 0.281 | 190.310 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
10 |
ARRDC1 | interactor | 6 | 0.333 | 5.888 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
11 |
ARRDC3 | interactor | 8 | 0.464 | 7.565 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
12 |
ARRDC4 | interactor | 4 | 0.833 | 0.517 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
13 |
ATN1 | protein found in more fusions | 7 | 0.667 | 1.987 | Atrophin-1 (PF03154, IPR002951): Atrophin-1 family |
14 |
ATXN3 | interactor | 10 | 0.361 | 16.158 | Josephin (PF02099, IPR006155): Josephin UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3 |
15 |
BECN1 | suppressor | 5 | 0.667 | 2.036 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting |
16 |
BID | oncoprotein | 6 | 0.500 | 7.694 | BID (PF06393, IPR010479): BH3 interacting domain (BID) |
17 |
BIN1 | suppressor | 5 | 0.500 | 3.872 | BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
18 |
C19orf70 | interactor | 7 | 0.524 | 9.466 | QIL1 (PF15884, IPR026769): Protein QIL1 |
19 |
CAV1 | suppressor | 15 | 0.190 | 202.739 | Caveolin (PF01146, IPR001612): Caveolin |
20 |
CBL | suppressor | 24 | 0.198 | 212.969 | Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain |
21 |
CBLC | oncoprotein | 9 | 0.472 | 16.199 | Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 |
22 |
CCDC155 | interactor | 1 | 0 | 0 | CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein EF-hand_9 (PF14658): EF-hand domain KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH |
23 |
CD244 | interactor | 3 | 0.333 | 21.782 | Receptor_2B4 (PF11465, IPR024303): Natural killer cell receptor 2B4 WBP-1 (PF11669, IPR021684): WW domain-binding protein 1 Ig_2 (PF13895, IPR007110): Immunoglobulin domain |
24 |
CDC34 | oncoprotein | 6 | 0.900 | 0.550 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
25 |
CEP120 | interactor | 5 | 0.100 | 46.193 | C2 (PF00168, IPR000008, SM00239): C2 domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) DUF3668 (PF12416, IPR022136): Cep120 protein DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain |
26 |
CFLAR | oncoprotein | 7 | 0.533 | 5.506 | DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain |
27 |
CHCHD3 | interactor | 9 | 0.389 | 208.771 | DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737) eIF3g (PF12353, IPR024675): Eukaryotic translation initiation factor 3 subunit G |
28 |
CHCHD6 | interactor | 5 | 0.400 | 103.281 | CHCH (PF06747, IPR010625): CHCH domain DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737) |
29 |
COL18A1 | oncoprotein | 2 | 1.000 | 0 | Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) DUF959 (PF06121, IPR010363): Domain of Unknown Function (DUF959) Endostatin (PF06482, IPR010515): Collagenase NC10 and Endostatin Fz (PF01392, IPR020067, SM00063): Fz domain Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily |
30 |
CPSF6 | interactor | 13 | 0.410 | 24.641 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
31 |
CPSF7 | interactor | 11 | 0.345 | 25.482 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
32 |
CSNK2A1 | oncoprotein | 23 | 0.281 | 139.932 | Pkinase (PF00069, IPR000719): Protein kinase domain |
33 |
CUL3 | protein found in more fusions | 53 | 0.113 | 1481.987 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
34 |
CXCR4 | interactor | 3 | 0.667 | 0.889 | 7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain CXCR4_N (PF12109, IPR022726): CXCR4 Chemokine receptor N terminal |
35 |
CYLD | suppressor | 9 | 0.444 | 16.913 | CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-HIT (PF04438, IPR007529): HIT zinc finger CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured |
36 |
DAZAP1 | interactor | 7 | 0.619 | 3.077 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) |
37 |
DTX1 | interactor | 9 | 0.429 | 6.330 | WWE (PF02825, IPR004170, SM00678): WWE domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
38 |
DTX3L | protein found in more fusions | 12 | 0.327 | 25.118 | KH_1 (PF00013, IPR004088, SM00322): KH domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
39 |
DVL1 | interactor | 14 | 0.372 | 35.726 | DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal |
40 |
DVL2 | interactor | 14 | 0.410 | 37.686 | DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal |
41 |
DVL3 | protein found in more fusions | 9 | 0.536 | 58.183 | DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal |
42 |
EGFR | oncoprotein | 46 | 0.116 | 1814.649 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
43 |
EIF2B4 | interactor | 2 | 0 | 7.835 | IF-2B (PF01008, IPR000649): Initiation factor 2 subunit family Mpp10 (PF04006, IPR007151): Mpp10 protein |
44 |
ELAVL1 | oncoprotein | 42 | 0.133 | 1231.285 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
45 |
ERBB4 | suppressor | 11 | 0.400 | 9.819 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
46 |
EWSR1 | oncoprotein | 24 | 0.253 | 161.298 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head |
47 |
FAM189A2 | interactor | 7 | 0.381 | 7.900 | CD20 (PF04103, IPR007237): CD20-like family |
48 |
FAM189B | interactor | 5 | 0.600 | 1.497 | CD20 (PF04103, IPR007237): CD20-like family TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family |
49 |
FBXL15 | interactor | 2 | 1.000 | 0 | LRV (PF01816, IPR004830): Leucine rich repeat variant F-box (PF00646, IPR001810, SM00256): F-box domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat |
50 |
FYN | oncoprotein | 10 | 0.194 | 256.294 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
51 |
GBA | interactor | 4 | 0.500 | 2.333 | Glyco_hydro_30 (PF02055, IPR001139): Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C (PF17189): Glycosyl hydrolase family 30 beta sandwich domain |
52 |
GGA3 | interactor | 6 | 0.533 | 8.308 | Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal GAT (PF03127, IPR004152): GAT domain VHS (PF00790, IPR002014, SM00288): VHS domain |
53 |
GLI1 | suppressor | 7 | 0.429 | 103.164 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain |
54 |
GLIS3 | interactor | 1 | 0 | 0 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain |
55 |
GNAI2 | oncoprotein | 4 | 0.500 | 5.602 | G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit |
56 |
GRAP2 | interactor | 5 | 0.500 | 27.460 | NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal SH2 (PF00017, IPR000980, SM00252): SH2 domain DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
57 |
GRB2 | oncoprotein | 23 | 0.229 | 203.059 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093) |
58 |
GSN | suppressor | 6 | 0.667 | 3.757 | Gelsolin (PF00626, IPR007123): Gelsolin repeat |
59 |
HDAC6 | oncoprotein | 18 | 0.228 | 95.220 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein |
60 |
HGS | interactor | 24 | 0.199 | 311.385 | FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate PIEZO (PF15917, IPR031805): Piezo |
61 |
HNRNPL | protein found in more fusions | 11 | 0.511 | 24.166 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
62 |
HNRNPR | interactor | 12 | 0.258 | 157.425 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1 |
63 |
HNRNPUL1 | protein found in more fusions | 9 | 0.429 | 115.737 | Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
64 |
HTT | protein found in more fusions | 11 | 0.311 | 37.860 | HEAT (PF02985, IPR000357): HEAT repeat SPX (PF03105, IPR004331): SPX domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3652 (PF12372, IPR024613): Huntingtin protein region Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
65 |
IKBKB | protein found in more fusions | 15 | 0.275 | 66.952 | FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain |
66 |
IMMT | protein found in more fusions | 13 | 0.197 | 259.067 | Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein |
67 |
ITSN1 | interactor | 7 | 0.467 | 5.631 | C2 (PF00168, IPR000008, SM00239): C2 domain VIT1 (PF01988, IPR008217): VIT family DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) SH3_9 (PF14604, IPR001452): Variant SH3 domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748) INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region PH_13 (PF16652, IPR001849): Pleckstrin homology domain |
68 |
JUN | oncoprotein | 17 | 0.342 | 46.444 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor |
69 |
KLF10 | suppressor | 1 | 0 | 0 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain AAA_33 (PF13671): AAA domain |
70 |
KPNA2 | interactor | 11 | 0.309 | 125.724 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat |
71 |
KPNB1 | protein found in more fusions | 16 | 0.314 | 69.420 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat |
72 |
KRAS | oncoprotein | 10 | 0.083 | 123.114 | Ras (PF00071, IPR001806, SM00173): Ras family |
73 |
LAPTM5 | oncoprotein | 6 | 0.600 | 3.979 | Mtp (PF03821, IPR004687): Golgi 4-transmembrane spanning transporter |
74 |
LATS1 | suppressor | 8 | 0.464 | 12.447 | Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6 Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
75 |
LDLRAD3 | interactor | 2 | 1.000 | 0 | DUF1668 (PF07893, IPR012871): Protein of unknown function (DUF1668) Opy2 (PF09463, IPR018571): Opy2 protein Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A RCR (PF12273, IPR020999): Chitin synthesis regulation, resistance to Congo red |
76 |
LDLRAD4 | interactor | 7 | 0.476 | 5.724 | Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615) |
77 |
LITAF | suppressor | 5 | 0.500 | 3.199 | zf-LITAF-like (PF10601, IPR006629, SM00714): LITAF-like zinc ribbon domain DUF3824 (PF12868, IPR024436): Domain of unknwon function (DUF3824) |
78 |
LRRK2 | oncoprotein | 11 | 0.244 | 41.763 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain |
79 |
MAP2K4 | suppressor | 9 | 0.536 | 9.837 | Pkinase (PF00069, IPR000719): Protein kinase domain |
80 |
MAP3K7 | oncoprotein | 17 | 0.325 | 56.711 | Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
81 |
MAPK8 | oncoprotein | 14 | 0.321 | 50.485 | DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530) Pkinase (PF00069, IPR000719): Protein kinase domain |
82 |
MAVS | interactor | 7 | 0.600 | 4.723 | Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat CARD_2 (PF16739, IPR031964): Caspase recruitment domain |
83 |
MDM2 | oncoprotein | 29 | 0.188 | 260.151 | Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
84 |
MGRN1 | interactor | 9 | 0.278 | 18.596 | zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
85 |
MINOS1 | interactor | 6 | 0.533 | 17.723 | DUF543 (PF04418, IPR007512): Domain of unknown function (DUF543) |
86 |
MLANA | interactor | 1 | 0 | 0 | MLANA (PF14991, IPR029242): Protein melan-A |
87 |
MMGT1 | interactor | 9 | 0.306 | 89.500 | MMgT (PF10270, IPR018937): Membrane magnesium transporter |
88 |
MOV10 | interactor | 22 | 0.121 | 446.119 | AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain |
89 |
N4BP1 | interactor | 3 | 1.000 | 0 | Enterotoxin_b (PF01376, IPR001835): Heat-labile enterotoxin beta chain RNase_Zc3h12a (PF11977, IPR021869): Zc3h12a-like Ribonuclease NYN domain |
90 |
NCOA1 | oncoprotein | 11 | 0.444 | 20.765 | DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein |
91 |
NDFIP1 | interactor | 7 | 0.381 | 21.300 | DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370) WBP-1 (PF11669, IPR021684): WW domain-binding protein 1 Comm (PF15957, IPR031878): Commissureless |
92 |
NDFIP2 | interactor | 4 | 0.500 | 4.112 | DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370) |
93 |
NDUFA4 | interactor | 9 | 0.286 | 63.837 | B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit |
94 |
NEDD9 | protein found in more fusions | 5 | 0.667 | 2.786 | Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513) SH3_9 (PF14604, IPR001452): Variant SH3 domain |
95 |
NFE2 | interactor | 4 | 0.667 | 0.500 | bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor Peptidase_Mx (PF15887, IPR031321): Putative zinc-binding metallo-peptidase |
96 |
NOTCH1 | suppressor | 16 | 0.248 | 44.559 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) |
97 |
NUDT21 | protein found in more fusions | 7 | 0.733 | 2.168 | NUDIX_2 (PF13869, IPR016706): Nucleotide hydrolase |
98 |
NUMB | suppressor | 6 | 0.600 | 6.895 | NumbF (PF06311, IPR010449): NUMB domain PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) |
99 |
OCLN | interactor | 4 | 0.500 | 2.713 | MARVEL (PF01284, IPR008253): Membrane-associating domain Occludin_ELL (PF07303, IPR010844): Occludin homology domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal |
100 |
PABPC1 | oncoprotein | 12 | 0.400 | 29.502 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain YflT (PF11181, IPR025889): Heat induced stress protein YflT |
101 |
PACSIN1 | interactor | 3 | 1.000 | 0 | FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605) DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446) SH3_9 (PF14604, IPR001452): Variant SH3 domain NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif |
102 |
PCBP2 | protein found in more fusions | 11 | 0.422 | 37.073 | Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein KH_2 (PF07650, IPR004044): KH domain KH_1 (PF00013, IPR004088, SM00322): KH domain |
103 |
PCNA | oncoprotein | 12 | 0.382 | 20.117 | PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain |
104 |
PDCD6IP | interactor | 14 | 0.295 | 56.904 | BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV |
105 |
PHB | suppressor | 10 | 0.289 | 178.575 | Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290) |
106 |
PHB2 | interactor | 6 | 0.533 | 27.125 | DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605) Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family |
107 |
PLEKHB2 | interactor | 2 | 1.000 | 0 | PH (PF00169, IPR001849, SM00233): PH domain |
108 |
POLR2A | protein found in more fusions | 19 | 0.294 | 128.474 | RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat |
109 |
POLR2B | interactor | 9 | 0.667 | 29.940 | RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 (PF04566, IPR007646): RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 (PF04567, IPR007647): RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7 |
110 |
POLR2C | interactor | 13 | 0.439 | 64.136 | RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain |
111 |
POLR2E | protein found in more fusions | 12 | 0.545 | 18.746 | RNA_pol_Rpb5_C (PF01191, IPR000783): RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N (PF03871, IPR005571): RNA polymerase Rpb5, N-terminal domain |
112 |
POU5F1 | oncoprotein | 7 | 0.400 | 45.756 | Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain |
113 |
PPP1CA | suppressor | 18 | 0.190 | 248.929 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
114 |
PRKACA | interactor | 8 | 0.286 | 171.008 | Pkinase (PF00069, IPR000719): Protein kinase domain |
115 |
PTCH1 | suppressor | 6 | 0.467 | 12.896 | Patched (PF02460, IPR003392): Patched family |
116 |
RASSF5 | suppressor | 5 | 0.333 | 19.107 | RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain |
117 |
RIPK1 | protein found in more fusions | 12 | 0.345 | 38.929 | Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif |
118 |
RNF11 | protein found in more fusions | 18 | 0.279 | 69.549 | zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger |
119 |
RPAP2 | interactor | 8 | 0.500 | 54.647 | NAD_Gly3P_dh_N (PF01210, IPR011128): NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus RPAP2_Rtr1 (PF04181, IPR007308): Rtr1/RPAP2 family SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein |
120 |
RPAP3 | interactor | 9 | 0.694 | 9.746 | TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3 Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat |
121 |
SAMM50 | interactor | 8 | 0.429 | 111.125 | Bac_surface_Ag (PF01103, IPR000184): Surface antigen POTRA (PF07244, IPR010827): Surface antigen variable number repeat |
122 |
SCAMP3 | interactor | 5 | 0.600 | 6.659 | SCAMP (PF04144, IPR007273): SCAMP family |
123 |
SCNN1A | interactor | 5 | 0.500 | 2.963 | ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel |
124 |
SCNN1B | oncoprotein | 3 | 1.000 | 0 | ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel |
125 |
SF1 | protein found in more fusions | 9 | 0.429 | 10.388 | UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181) zf-CCHC (PF00098, IPR001878): Zinc knuckle KH_1 (PF00013, IPR004088, SM00322): KH domain RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain |
126 |
SFN | suppressor | 11 | 0.422 | 25.397 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
127 |
SGK3 | interactor | 1 | 0 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain PX (PF00787, IPR001683, SM00312): PX domain |
128 |
SH3GL2 | oncoprotein | 7 | 0.600 | 7.292 | BAR (PF03114, IPR004148, SM00721): BAR domain SH3_2 (PF07653, IPR011511): Variant SH3 domain |
129 |
SH3GLB1 | suppressor | 3 | 1.000 | 0 | BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
130 |
SLC1A5 | interactor | 4 | 0.500 | 0.929 | SDF (PF00375, IPR001991): Sodium:dicarboxylate symporter family |
131 |
SLC25A3 | interactor | 7 | 0.286 | 124.661 | Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein |
132 |
SLC3A2 | interactor | 5 | 0.400 | 8.640 | Alpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain DUF3459 (PF11941, IPR022567): Domain of unknown function (DUF3459) SLC3A2_N (PF16028, IPR031984): Solute carrier family 3 member 2 N-terminus |
133 |
SMAD2 | suppressor | 23 | 0.264 | 215.436 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
134 |
SMAD3 | oncoprotein | 27 | 0.249 | 152.262 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
135 |
SMAD6 | interactor | 10 | 0.489 | 16.323 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
136 |
SMAD7 | interactor | 15 | 0.362 | 36.124 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
137 |
SMARCC1 | suppressor | 18 | 0.478 | 42.525 | SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF2618 (PF10940, IPR021237): Protein of unknown function (DUF2618) PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal |
138 |
SMARCC2 | interactor | 20 | 0.332 | 105.956 | GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain SWIRM (PF04433, IPR007526): SWIRM domain DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal |
139 |
SMARCE1 | interactor | 11 | 0.582 | 13.224 | DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) GCN5L1 (PF06320, IPR009395): GCN5-like protein 1 (GCN5L1) Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box Ferlin_C (PF16165, IPR032362): Ferlin C-terminus |
140 |
SNX18 | interactor | 5 | 0.600 | 2.196 | PX (PF00787, IPR001683, SM00312): PX domain BAR_3_WASP_bdg (PF10456, IPR019497): WASP-binding domain of Sorting nexin protein SH3_9 (PF14604, IPR001452): Variant SH3 domain |
141 |
SNX9 | protein found in more fusions | 4 | 0.667 | 0.251 | PX (PF00787, IPR001683, SM00312): PX domain BAR_3_WASP_bdg (PF10456, IPR019497): WASP-binding domain of Sorting nexin protein SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
142 |
SPG20 | interactor | 5 | 0.600 | 1.537 | MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain Senescence (PF06911, IPR009686): Senescence-associated protein |
143 |
STAM | interactor | 8 | 0.429 | 22.413 | GAT (PF03127, IPR004152): GAT domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
144 |
STAM2 | interactor | 15 | 0.314 | 76.638 | GAT (PF03127, IPR004152): GAT domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
145 |
TAB1 | interactor | 14 | 0.286 | 68.866 | PP2C (PF00481, IPR001932): Protein phosphatase 2C |
146 |
TADA2A | interactor | 7 | 0.143 | 55.646 | SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain |
147 |
TAX1BP1 | interactor | 7 | 0.476 | 9.936 | CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain PolyA_pol (PF01743, IPR002646): Poly A polymerase head domain Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 zf-C2H2_4 (PF13894): C2H2-type zinc finger PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain |
148 |
TGFBR1 | oncoprotein | 12 | 0.424 | 31.537 | Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain Pkinase (PF00069, IPR000719): Protein kinase domain TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif |
149 |
TMEM171 | interactor | 3 | 0.667 | 1.249 | TMEM171 (PF15471, IPR029173): Transmembrane protein family 171 |
150 |
TMEM255A | interactor | 2 | 1.000 | 0 | FAM70 (PF14967, IPR028014): FAM70 protein |
151 |
TMEM51 | interactor | 2 | 1.000 | 0 | WBP-1 (PF11669, IPR021684): WW domain-binding protein 1 TMEM51 (PF15345, IPR029265): Transmembrane protein 51 |
152 |
TMEM92 | interactor | 3 | 0.667 | 1.169 | WBP-1 (PF11669, IPR021684): WW domain-binding protein 1 |
153 |
TNFRSF10B | suppressor | 9 | 0.417 | 21.580 | Death (PF00531, IPR000488, SM00005): Death domain RskA (PF10099, IPR018764): Anti-sigma-K factor rskA TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region |
154 |
TOLLIP | interactor | 10 | 0.389 | 19.401 | C2 (PF00168, IPR000008, SM00239): C2 domain CUE (PF02845, IPR003892, SM00546): CUE domain |
155 |
TP53 | suppressor | 42 | 0.156 | 904.822 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
156 |
TP53BP2 | suppressor | 11 | 0.273 | 91.000 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Erp_C (PF06780, IPR009618): Erp protein C-terminus SlyX (PF04102, IPR007236): SlyX SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
157 |
TP63 | suppressor | 13 | 0.364 | 32.108 | Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) |
158 |
TP73 | suppressor | 8 | 0.476 | 6.405 | P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) |
159 |
TPD52 | oncoprotein | 5 | 0.333 | 11.392 | TPD52 (PF04201, IPR007327): Tumour protein D52 family |
160 |
TRAF6 | protein found in more fusions | 25 | 0.199 | 224.299 | SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
161 |
TRAK2 | interactor | 2 | 0 | 11.002 | ZapB (PF06005, IPR009252): Cell division protein ZapB HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region Milton (PF12448, IPR022154): Kinesin associated protein |
162 |
TRPV4 | interactor | 3 | 0.667 | 1.028 | Ion_trans (PF00520, IPR005821): Ion transport protein Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) |
163 |
TXNIP | suppressor | 4 | 1.000 | 0 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
164 |
UBA1 | protein found in more fusions | 19 | 0.275 | 100.227 | ThiF (PF00899, IPR000594): ThiF family E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site |
165 |
UBA6 | interactor | 8 | 0.571 | 4.700 | ThiF (PF00899, IPR000594): ThiF family E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site |
166 |
UBAP2 | interactor | 4 | 0.667 | 0.662 | Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) CUE (PF02845, IPR003892, SM00546): CUE domain HlyE (PF06109, IPR027018): Haemolysin E (HlyE) MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein DUF3697 (PF12478, IPR022166): Ubiquitin-associated protein 2 UBA_4 (PF14555): UBA-like domain |
167 |
UBAP2L | interactor | 6 | 0.600 | 5.533 | CUE (PF02845, IPR003892, SM00546): CUE domain DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch DUF3697 (PF12478, IPR022166): Ubiquitin-associated protein 2 UBA_4 (PF14555): UBA-like domain Comm (PF15957, IPR031878): Commissureless |
168 |
UBC | protein found in more fusions | 57 | 0.141 | 1889.447 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
169 |
UBE2D1 | interactor | 21 | 0.289 | 106.509 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
170 |
UBE2D2 | oncoprotein | 20 | 0.374 | 51.714 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
171 |
UBE2D3 | interactor | 19 | 0.261 | 56.799 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
172 |
UBE2E1 | protein found in more fusions | 10 | 0.278 | 11.867 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein |
173 |
UBE2E3 | interactor | 9 | 0.429 | 8.697 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
174 |
UBE2G1 | protein found in more fusions | 4 | 0.667 | 0.540 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
175 |
UBE2J2 | interactor | 4 | 0.667 | 1.318 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
176 |
UBE2K | interactor | 10 | 0.444 | 19.639 | UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
177 |
UBE2L3 | interactor | 22 | 0.238 | 200.364 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
178 |
URI1 | protein found in more fusions | 7 | 0.533 | 27.316 | CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein Prefoldin (PF02996, IPR004127): Prefoldin subunit DUF3835 (PF12927, IPR024325): Domain of unknown function (DUF3835) SCAPER_N (PF16501, IPR032446): S phase cyclin A-associated protein in the endoplasmic reticulum |
179 |
USP12 | suppressor | 5 | 0.600 | 2.675 | UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase |
180 |
USP13 | interactor | 8 | 0.464 | 18.934 | UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein |
181 |
USP5 | interactor | 10 | 0.356 | 23.212 | UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein |
182 |
USP9X | interactor | 12 | 0.424 | 25.746 | DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722) UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain |
183 |
VDAC2 | interactor | 8 | 0.464 | 64.261 | Porin_3 (PF01459, IPR027246): Eukaryotic porin |
184 |
WBP1 | interactor | 4 | 0.500 | 0.433 | WBP-1 (PF11669, IPR021684): WW domain-binding protein 1 |
185 |
WBP2 | interactor | 4 | 0.500 | 0.433 | GRAM (PF02893, IPR004182, SM00568): GRAM domain Vps36_ESCRT-II (PF11605, IPR021648): Vacuolar protein sorting protein 36 Vps36 |
186 |
WDR48 | suppressor | 7 | 0.619 | 5.154 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337) |
187 |
WWOX | suppressor | 39 | 0.132 | 641.652 | adh_short (PF00106, IPR002198): short chain dehydrogenase WW (PF00397, IPR001202, SM00456): WW domain |
188 |
WWP1 | oncoprotein | 37 | 0.106 | 537.417 | C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
189 |
YAP1 | suppressor | 28 | 0.135 | 356.938 | Bindin (PF02084, IPR000775): Bindin WW (PF00397, IPR001202, SM00456): WW domain GspL_C (PF12693, IPR025691): GspL periplasmic domain FAM181 (PF15238, IPR029359): FAM181 |
190 |
YWHAQ | interactor | 16 | 0.158 | 328.338 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |