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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MTX2, LNPK (from a repository: Wed Dec 11 18:05:32 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins7 (15.22 %)
The number (and %) of the tumor suppressors3 (6.52 %)
Total number of binary PPIs (saturation %)118 (11.40 %)
The number (and %) of affected PPIs44 (37.29 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI4.783
Assortativity coefficient-0.3614
The network average Clustering coefficient0.403
The number (and %) of a zero Clustering coefficients12 (26.09 %)
The number (and %) of a zero Betweenness Centrality15 (32.61 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MTX2,LNPK All fusions
Proteins found in more fusions CHMP1A (see 2 fusions); IMMT (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MTX2parental protein250.117802.813Tom37 (PF10568, IPR019564): Outer mitochondrial membrane transport complex protein
GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
2 LNPKparental protein190.064769.828zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4153 (PF13687, IPR025291): Domain of unknown function (DUF4153)
3 APOOLinteractor70.6672.152ApoO (PF09769, IPR019166): Apolipoprotein O
4 ATP1B3interactor30.33314.391Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
5 C19orf70interactor70.5246.581QIL1 (PF15884, IPR026769): Protein QIL1
6 CCDC155interactor100CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
EF-hand_9 (PF14658): EF-hand domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
7 CD1Binteractor100C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
MLANA (PF14991, IPR029242): Protein melan-A
MHC_I_3 (PF16497, IPR011161): MHC-I family domain
8 CD244interactor21.0000Receptor_2B4 (PF11465, IPR024303): Natural killer cell receptor 2B4
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
9 CEP120interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
DUF3668 (PF12416, IPR022136): Cep120 protein
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
10 CHCHD3interactor80.42982.692DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
eIF3g (PF12353, IPR024675): Eukaryotic translation initiation factor 3 subunit G
11 CHCHD6interactor50.50029.522CHCH (PF06747, IPR010625): CHCH domain
DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
12 CHMP1Aprotein found in more fusions40.33327.239Snf7 (PF03357, IPR005024): Snf7
13 CHRNA9interactor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
14 EDAinteractor30.6671.000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
15 EIF2B4interactor100IF-2B (PF01008, IPR000649): Initiation factor 2 subunit family
Mpp10 (PF04006, IPR007151): Mpp10 protein
16 ELAVL1oncoprotein90.32195.141RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
17 GOLT1Binteractor120.288369.489Got1 (PF04178, IPR007305): Got1/Sft2-like family
18 HNRNPRinteractor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
19 HTR3Cinteractor21.0000Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
20 IMMTprotein found in more fusions110.267133.414Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
21 KRASoncoprotein50.16784.690Ras (PF00071, IPR001806, SM00173): Ras family
22 LLGL2interactor200Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal
LLGL (PF08366, IPR013577): LLGL2
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
23 LPAR1oncoprotein30.33342.1037tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
24 LYPD3oncoprotein30.6672.329DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753)
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
25 MINOS1interactor50.5007.086DUF543 (PF04418, IPR007512): Domain of unknown function (DUF543)
26 MMGT1interactor130.282213.289MMgT (PF10270, IPR018937): Membrane magnesium transporter
27 MOV10interactor60.133135.174AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
28 NDUFA4interactor60.5002.971B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
29 PHBsuppressor70.52449.290Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
30 PHB2interactor50.9008.331DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
31 PPP1CAsuppressor100Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
32 SAMM50interactor60.6672.400Bac_surface_Ag (PF01103, IPR000184): Surface antigen
POTRA (PF07244, IPR010827): Surface antigen variable number repeat
33 SLC25A3interactor40.5005.808Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
34 SLC39A4suppressor21.0000Zip (PF02535, IPR003689): ZIP Zinc transporter
Class_IIIsignal (PF04021, IPR007166): Class III signal peptide
35 SYNPRinteractor100Frizzled (PF01534, IPR000539): Frizzled/Smoothened family membrane region
MARVEL (PF01284, IPR008253): Membrane-associating domain
36 TADA2Ainteractor100SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
37 TCTN2interactor40.50013.330DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
38 TCTN3interactor40.33339.804DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
39 TMED3interactor2025.610EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
40 TMEM17interactor2010.030Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
41 TMEM216interactor40.83310.030Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
42 TMEM67interactor21.0000Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
Tme5_EGF_like (PF09064, IPR015149): Thrombomodulin like fifth domain, EGF-like
Meckelin (PF09773, IPR019170): Meckelin (Transmembrane protein 67)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
43 TPD52oncoprotein40.6672.103TPD52 (PF04201, IPR007327): Tumour protein D52 family
44 TRAK2interactor2012.387ZapB (PF06005, IPR009252): Cell division protein ZapB
HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
Milton (PF12448, IPR022154): Kinesin associated protein
45 VDAC2interactor80.50076.972Porin_3 (PF01459, IPR027246): Eukaryotic porin
46 YWHAQinteractor21.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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