Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins ND4, MTATP6P1 (from a repository: Sun Jul 5 16:19:44 2020)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 15 The number (and %) of the onco-proteins 2 (13.33 %) The number (and %) of the tumor suppressors 3 (20.00 %) Total number of binary PPIs (saturation %) 41 (39.05 %) The number (and %) of affected PPIs 13 (31.71 %) The number of possible different fusions 4 PPI diameter 2 PPI radius inf The average degree of PPI 4.800 Assortativity coefficient -0.4045 The network average Clustering coefficient 0.573 The number (and %) of a zero Clustering coefficients 4 (26.67 %) The number (and %) of a zero Betweenness Centrality 5 (33.33 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: MTATP6P1,ND4	All fusions
Proteins found in more fusions	APC (see 1 fusions); GRB2 (see 1 fusions); NDUFS3 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	MTATP6P1	interactor	0	0	0	NA
2	ND4	parental protein	13	0.295	92.286	NA
3	APC	suppressor	2	0	0	APC_15aa (PF05972, IPR009240): APC 15 residue motif APC_basic (PF05956, IPR009234): APC basic domain APC_r (PF05923): APC repeat Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) EB1_binding (PF05937, IPR009232): EB-1 Binding Domain FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) SAMP (PF05924, IPR009224): SAMP Motif Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4 Arm_APC_u3 (PF16629): Armadillo-associated region on APC APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6 APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
4	ATM	suppressor	4	0.667	1.000	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
5	ECSIT	interactor	6	0.900	0.286	ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
6	GRB2	oncoprotein	2	0	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
7	LIG4	interactor	2	1.000	0	APG17 (PF04108, IPR007240): Autophagy protein Apg17 BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
8	NDUFA11	interactor	6	0.933	0.286	7kD_coat (PF02495, IPR003411): 7kD viral coat protein Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
9	NDUFA8	interactor	8	0.571	9.000	CHCH (PF06747, IPR010625): CHCH domain Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191 Cdd1 (PF11731, IPR021725): Pathogenicity locus
10	NDUFS3	protein found in more fusions	9	0.750	3.286	Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
11	NDUFS4	interactor	6	0.933	0.286	ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
12	NDUFS5	interactor	7	0.714	3.000	Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
13	NDUFS6	interactor	6	0.933	0.286	Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
14	NKX3-1	suppressor	1	0	0	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
15	TIMMDC1	interactor	5	0.900	0.286	Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family

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