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Visualization interactions

Powered by Cytoscape Web for: parental proteins PDPN, VEZT (from a repository: Tue Aug 4 02:57:36 2020)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins3 (21.43 %)
The number (and %) of the tumor suppressors1 (7.14 %)
Total number of binary PPIs (saturation %)24 (26.37 %)
The number (and %) of affected PPIs12 (50.00 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI3.000
Assortativity coefficient-0.2569
The network average Clustering coefficient0.455
The number (and %) of a zero Clustering coefficients6 (42.86 %)
The number (and %) of a zero Betweenness Centrality11 (78.57 %)


List of the fusions

PPI for parental proteins: VEZT,PDPN All fusions
Proteins found in more fusions CDH1 (see 3 fusions); CTNNA1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 VEZTparental protein110.16486.000ATPase_2 (PF01637, IPR011579): ATPase domain predominantly from Archaea
Vezatin (PF12632, IPR026859): Mysoin-binding motif of peroxisomes
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
2 PDPNparental protein100Podoplanin (PF05808, IPR008783): Podoplanin
Sensor (PF13796, IPR025828): Putative sensor
3 CDH1suppressor51.0000Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
4 CTNNA1oncoprotein51.0000Vinculin (PF01044, IPR006077): Vinculin family
5 CTNNB1oncoprotein50.7003.000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
6 ELAVL1oncoprotein50.5003.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
7 EVC2interactor100HBS1_N (PF08938, IPR015033): HBS1 N-terminus
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Histone_HNS (PF00816, IPR001801): H-NS histone family
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
8 MYO7Ainteractor41.0000FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
MyTH4 (PF00784, IPR000857, SM00139): MyTH4 domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
9 PLEKHO2interactor100PH (PF00169, IPR001849, SM00233): PH domain
10 TCTN2interactor21.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
11 TCTN3interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
12 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
13 TMEM216interactor21.0000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
14 TOM1L1interactor100GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain

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