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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)226
The number (and %) of the onco-proteins52 (23.01 %)
The number (and %) of the tumor suppressors30 (13.27 %)
Total number of binary PPIs (saturation %)2591 (10.19 %)
The number (and %) of affected PPIs225 (8.68 %)
The number of possible different fusions34
PPI diameter4
PPI radius2
The average degree of PPI22.212
Assortativity coefficient-0.2630
The network average Clustering coefficient0.499
The number (and %) of a zero Clustering coefficients12 (5.31 %)
The number (and %) of a zero Betweenness Centrality16 (7.08 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ZBTB38,CCT2 All fusions
Proteins found in more fusions U2AF2 (see 2 fusions); NPM1 (see 1 fusions); CUL1 (see 3 fusions); TRIM26 (see 1 fusions); GRB2 (see 1 fusions); LGALS3BP (see 2 fusions); VHL (see 1 fusions); GAN (see 1 fusions); HDAC5 (see 1 fusions); SNW1 (see 1 fusions); VCP (see 4 fusions); HSP90AA1 (see 2 fusions); HUWE1 (see 2 fusions); HSP90AB1 (see 1 fusions); EEF1D (see 3 fusions); TCF3 (see 4 fusions); SHC1 (see 1 fusions); TUBG1 (see 1 fusions); PSMC2 (see 1 fusions); STAU1 (see 2 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); MYC (see 1 fusions); ACTB (see 3 fusions); COPS5 (see 1 fusions); PEX14 (see 1 fusions); UBC (see 1 fusions); PRPF40A (see 2 fusions); TP53 (see 3 fusions); ILK (see 1 fusions); CRY2 (see 3 fusions); TRIM28 (see 1 fusions); MCM2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ZBTB38parental protein430.0252913.925BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_7 (PF15269): Zinc-finger
zf-C2H2_8 (PF15909, IPR031799): C2H2-type zinc ribbon
2 CCT2parental protein1820.12512483.288Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
3 ACTA1interactor130.46211.892Actin (PF00022, IPR004000, SM00268): Actin
4 ACTBoncoprotein360.343115.383Actin (PF00022, IPR004000, SM00268): Actin
5 ACTL6Ainteractor160.6837.805Actin (PF00022, IPR004000, SM00268): Actin
6 ACTR1Binteractor80.9290.691Actin (PF00022, IPR004000, SM00268): Actin
7 ACTR2interactor220.62324.106Actin (PF00022, IPR004000, SM00268): Actin
8 AHSA1interactor210.53330.214Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
9 ALKBH3interactor100.44414.9732OG-FeII_Oxy_2 (PF13532, IPR027450): 2OG-Fe(II) oxygenase superfamily
10 AMBRA1interactor160.57513.150Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Spt20 (PF12090, IPR021950): Spt20 family
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
11 ARMC6interactor120.6676.959Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Mis14 (PF08641, IPR013950): Kinetochore protein Mis14 like
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
12 ATF2oncoprotein150.46218.717bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
13 ATG16L1interactor80.6671.339ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2332 (PF10094, IPR011200): Uncharacterized protein conserved in bacteria (DUF2332)
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
14 ATP6V1B1interactor21.0000ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
15 B9D1interactor90.9720.250Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family
16 BTRConcoprotein290.362173.196WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
17 BUB1Boncoprotein120.43610.910Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Mad3_BUB1_II (PF08171, IPR012572): Mad3/BUB1 homology region 2
Pkinase (PF00069, IPR000719): Protein kinase domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
18 BUB3interactor170.59616.084WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
19 C11orf54interactor21.0000DUF1907 (PF08925, IPR015021, SM01168): Domain of Unknown Function (DUF1907)
20 CAMKMTinteractor80.5711.710Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
21 CASP7interactor50.5001.268Peptidase_C14 (PF00656, IPR011600): Caspase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
22 CBFA2T3suppressor4048.839NHR2 (PF08788, IPR014896): NHR2 domain like
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
zf-MYND (PF01753, IPR002893): MYND finger
Efg1 (PF10153, IPR019310): rRNA-processing protein Efg1
PRIMA1 (PF16101): Proline-rich membrane anchor 1
23 CCDC136suppressor206.099Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
Com_YlbF (PF06133, IPR010368): Control of competence regulator ComK, YlbF/YmcA
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Sec34 (PF04136, IPR007265): Sec34-like family
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
FlxA (PF14282, IPR025577): FlxA-like protein
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
24 CCDC8interactor330.435110.949Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
25 CCNE1oncoprotein90.4176.292Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
26 CCT3interactor1190.1702291.417Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
27 CCT4interactor1120.1751976.915Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
28 CCT5interactor970.2071296.490Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
29 CCT6Ainteractor1130.1762030.223Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
30 CCT6Binteractor370.300209.261Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
31 CCT7interactor1070.1772030.449Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
32 CCT8interactor1000.2151280.936Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
33 CDC20oncoprotein270.52642.789WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
34 CDC5Linteractor500.373816.638OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
35 CDK15interactor60.6671.302Pkinase (PF00069, IPR000719): Protein kinase domain
ACT_5 (PF13710): ACT domain
36 CDK2suppressor510.327509.365Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
37 CDK5oncoprotein150.6597.328Pkinase (PF00069, IPR000719): Protein kinase domain
38 CDK7oncoprotein90.6797.027Pkinase (PF00069, IPR000719): Protein kinase domain
39 CETN2interactor71.0000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
40 COPS5protein found in more fusions530.305578.036JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
41 CRY2protein found in more fusions210.45399.985DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
42 CTTNBP2interactor140.76916.288Carmo_coat_C (PF08462, IPR013669): Carmovirus coat protein
CortBP2 (PF09727, IPR019131): Cortactin-binding protein-2
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
43 CUL1suppressor530.326409.126Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
44 CUL3protein found in more fusions810.2211980.407Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
45 CUL7protein found in more fusions450.353389.904ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
46 CYB5Binteractor21.0000Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIP (PF00230, IPR000425): Major intrinsic protein
47 DCAF5interactor70.9050.394WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2634 (PF10934, IPR020288): Protein of unknown function (DUF2634)
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
48 DCAF7interactor110.8911.186WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
49 DDB2suppressor150.67027.265WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
50 DDX18interactor160.325114.924DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF4217 (PF13959, IPR025313, SM01178): Domain of unknown function (DUF4217)
51 DDX24interactor130.35992.410DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tti2 (PF10521, IPR018870): Tti2 family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
52 DHX36interactor70.23833.047DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
53 DNAJA1interactor440.328255.126DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
54 DNAJA4interactor120.6365.079DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
55 EEF1Dprotein found in more fusions200.46820.617EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
56 EEF2interactor310.355169.107EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
57 EHMT2interactor60.30026.788CDC45 (PF02724, IPR003874): CDC45-like protein
Pre-SET (PF05033, IPR007728): Pre-SET motif
Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family
SET (PF00856, IPR001214, SM00317): SET domain
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
58 EIF5Binteractor60.20023.873GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
MIase (PF02426, IPR026029): Muconolactone delta-isomerase
NOA36 (PF06524, IPR010531): NOA36 protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
IF-2 (PF11987, IPR023115): Translation-initiation factor 2
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
GTP_EFTU_D4 (PF14578, IPR029459): Elongation factor Tu domain 4
DUF4632 (PF15451, IPR027952): Domain of unknown function (DUF4632)
Coilin_N (PF15862, IPR031722): Coilin N-terminus
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
59 ELAVL2interactor3015.871RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
60 ENDOVinteractor100Endonuclease_5 (PF04493, IPR007581): Endonuclease V
61 ERLIN2interactor130.42325.891Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
62 ESR1suppressor410.306368.587Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
63 FAM86B2interactor110.8181.604Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
FAM86 (PF14904, IPR029426): Family of unknown function
64 FBXO6interactor400.346152.280FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
65 FBXW4oncoprotein110.8001.667WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
F-box-like (PF12937, IPR001810): F-box-like
F-box_4 (PF15966, IPR001810): F-box
66 FBXW8interactor150.6297.857WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
67 FCHSD2interactor60.40055.203Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil
DivIC (PF04977, IPR007060): Septum formation initiator
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
Rit1_C (PF17184): Rit1 N-terminal domain
68 FN1oncoprotein400.372207.772fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
69 FSD2interactor100Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
REJ (PF02010, IPR002859): REJ domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
IZUMO (PF15005, IPR029389): Izumo sperm-egg fusion, Ig domain-associated
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
70 FUSsuppressor400.512111.317Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
71 FYCO1interactor61.0000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
RUN (PF02759, IPR004012, SM00593): RUN domain
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
GOLD_2 (PF13897, IPR009038): Golgi-dynamics membrane-trafficking
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4578 (PF15147, IPR028106): Domain of unknown function (DUF4578)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
72 GANprotein found in more fusions200.50322.939BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
73 GPR37interactor60.9330.0657tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
74 GRB2oncoprotein350.462221.381SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
75 GSPT1oncoprotein70.42925.560GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
76 GSPT2interactor21.0000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
77 GTF2Iinteractor160.44275.137GTF2I (PF02946, IPR004212): GTF2I-like repeat
78 HDAC1suppressor310.370470.883FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
79 HDAC3suppressor180.596141.890Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
80 HDAC5protein found in more fusions340.47373.966Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
81 HIST2H2ABinteractor40.16714.620Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
82 HSP90AA1oncoprotein730.2221516.604HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
83 HSP90AB1oncoprotein570.301443.183HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
84 HSP90B1suppressor270.43650.251CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
85 HSPA4interactor450.292408.476Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
86 HSPE1interactor170.53714.384Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
87 HSPH1oncoprotein200.41643.007HSP70 (PF00012, IPR013126): Hsp70 protein
SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain
88 HUWE1oncoprotein500.409222.230BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
89 IGBP1interactor130.80814.795TAP42 (PF04177, IPR007304): TAP42-like family
90 IKBKEinteractor130.6529.042IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
91 ILKsuppressor270.409126.653Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
92 IPO7interactor160.217141.218Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
DUF3730 (PF12530, IPR022542): Protein of unknown function (DUF3730)
93 IQGAP1interactor300.359132.561CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
94 IRAK1interactor210.55830.956Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
95 ISG15suppressor130.42313.027ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
96 ITGA4interactor330.49051.275FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
97 JAK3oncoprotein71.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
98 KIF21Ainteractor120.8791.126DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Strep_SA_rep (PF06696, IPR009578): Streptococcal surface antigen repeat
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
TSNAXIP1_N (PF15739, IPR032755): Translin-associated factor X-interacting N-terminus
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
99 KPNA4interactor140.6599.345Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
100 KRASoncoprotein170.217515.183Ras (PF00071, IPR001806, SM00173): Ras family
101 KRT40interactor40.33329.534Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
102 KRTAP10-7interactor31.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
103 KRTAP10-9interactor40.6673.387Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
104 LFNGoncoprotein31.0000Fringe (PF02434, IPR003378): Fringe-like
105 LGALS3BPoncoprotein300.58930.642BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain
106 LRR1interactor50.40031.399LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
107 LRRK1interactor60.8000.427Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
108 LZTS2suppressor70.09556.676CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127)
Fez1 (PF06818): Fez1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
109 MAPK10suppressor70.6002.432Pkinase (PF00069, IPR000719): Protein kinase domain
110 MAPK8oncoprotein150.56027.663DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
111 MCM2oncoprotein540.356538.107AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
112 MEPCEinteractor140.44095.871Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3)
Methyltransf_23 (PF13489): Methyltransferase domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
113 METTL18interactor120.60613.488Methyltransf_23 (PF13489): Methyltransferase domain
114 METTL21Binteractor160.6509.406Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
115 MKS1interactor100.68921.911B9-C2 (PF07162, IPR010796): Ciliary basal body-associated, B9 protein
116 MLST8interactor40.8330.635Hira (PF07569, IPR011494): TUP1-like enhancer of split
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
117 MOB4interactor150.8673.668Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
118 MRPS35interactor70.52445.227MRP-S28 (PF10213, IPR019349): Mitochondrial ribosomal subunit protein
119 MRPS5interactor80.46451.999Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
120 MTUS2suppressor90.10785.648DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496)
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
FAM184 (PF15665): Family with sequence similarity 184, A and B
121 MYBBP1Asuppressor170.47183.208DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Pol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal
122 MYConcoprotein470.324390.086HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
123 NEDD1interactor160.64212.488NRBF2 (PF08961, IPR015056): Nuclear receptor-binding factor 2, autophagy regulator
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
FliM (PF02154, IPR001689): Flagellar motor switch protein FliM
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Mto2_bdg (PF12808, IPR024545): Micro-tubular organiser Mto1 C-term Mto2-binding region
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
124 NEMFinteractor30.6675.746DUF814 (PF05670, IPR008532): Domain of unknown function (DUF814)
FbpA (PF05833, IPR008616): Fibronectin-binding protein A N-terminus (FbpA)
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PGA2 (PF07543, IPR011431): Protein trafficking PGA2
DUF3441 (PF11923, IPR021846): Domain of unknown function (DUF3441)
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
125 NIPSNAP1interactor160.65825.773NIPSNAP (PF07978, IPR012577): NIPSNAP
126 NOC2Linteractor130.41065.102CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Noc2 (PF03715, IPR005343): Noc2p family
CEND1 (PF15677, IPR020162): Cell cycle exit and neuronal differentiation protein 1
127 NOS2interactor230.54514.026FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
128 NPM1suppressor560.335746.144Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
129 NSFL1Cinteractor90.52815.479SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
130 NSMAFinteractor90.8610.395Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
GRAM (PF02893, IPR004182, SM00568): GRAM domain
NABP (PF07990, IPR012940): Nucleic acid binding protein NABP
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
131 NTRK1oncoprotein860.2142700.738I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
132 NXF1interactor400.219582.541NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
133 OBSL1interactor420.335428.584BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
134 PACRGsuppressor150.6578.815ParcG (PF10274, IPR019399): Parkin co-regulated protein
135 PAN2interactor210.367131.282RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
136 PARK2suppressor310.363137.135IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
137 PCK1interactor100.4892.443PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
138 PDE4DIPoncoprotein50.20033.473ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1220 (PF06758, IPR010630, SM01148): Repeat of unknown function (DUF1220)
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
IncA (PF04156, IPR007285): IncA protein
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
FAM76 (PF16046, IPR032017): FAM76 protein
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
139 PDK3interactor91.0000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
140 PEX14protein found in more fusions140.5647.295HemX (PF04375, IPR007470): HemX, putative uroporphyrinogen-III C-methyltransferase
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
141 PEX7interactor90.9720.182WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
142 PLK4interactor70.40045.768ABC1 (PF03109, IPR004147): ABC1 family
Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
DUF4520 (PF15016, IPR027865): Domain of unknown function (DUF4520)
143 POC1Ainteractor100.7115.961WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
144 POC1Binteractor30.6670.829WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
145 POP1interactor120.38264.650POP1 (PF06978, IPR009723): Ribonucleases P/MRP protein subunit POP1
POPLD (PF08170, IPR012590): POPLD (NUC188) domain
146 PPP1CConcoprotein180.61412.362Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
147 PPP2CAsuppressor390.449134.702Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
148 PPP2CBsuppressor250.63028.865Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
149 PPP2R2Ainteractor190.75411.920WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
150 PPP2R2Binteractor150.8484.860WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
151 PPP2R2Csuppressor130.8333.491WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
152 PPP2R2Dinteractor160.8503.939WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
153 PPP4Cinteractor180.77812.587Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
154 PRKCDBPsuppressor21.0000A1_Propeptide (PF07966, IPR012848): A1 Propeptide
PTRF_SDPR (PF15237, IPR026752): PTRF/SDPR family
155 PRPF4interactor220.66722.629PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
156 PRPF40Aprotein found in more fusions160.57116.625FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
157 PSMA3interactor330.427112.960Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
158 PSMB8interactor61.0000Proteasome (PF00227, IPR001353): Proteasome subunit
159 PSMC2protein found in more fusions340.430113.414AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
160 PSMC6interactor240.41556.231AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
161 PSMD2oncoprotein360.243215.669PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
162 PTCD3interactor90.38940.861PPR (PF01535, IPR002885): PPR repeat
PPR_2 (PF13041, IPR002885): PPR repeat family
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
163 PTPAsuppressor110.8551.534PTPA (PF03095, IPR004327): Phosphotyrosyl phosphate activator (PTPA) protein
164 RAD21oncoprotein170.51518.291Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
165 RALBP1interactor3017.923DDHD (PF02862, IPR004177, SM01127): DDHD domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SlyX (PF04102, IPR007236): SlyX
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505)
Nod1 (PF17114, IPR032634): Gef2-related medial cortical node protein Nod1
166 RBBP6oncoprotein80.25056.332DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936)
DWNN (PF08783, IPR014891): DWNN domain
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
U-box (PF04564, IPR003613, SM00504): U-box domain
SBF2 (PF12335, IPR022096): Myotubularin protein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-CCHC_2 (PF13696, IPR025829): Zinc knuckle
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
PRIMA1 (PF16101): Proline-rich membrane anchor 1
167 RFWD2suppressor150.72563.291Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IncA (PF04156, IPR007285): IncA protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
WD40_like (PF17005, IPR031544): WD40-like domain
168 RFWD3interactor120.6822.484OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
169 RPL15interactor200.453113.215Ribosomal_L15e (PF00827, IPR000439): Ribosomal L15
170 RPL26L1interactor110.41862.153Ribosomal_L26 (PF16906, IPR005756): Ribosomal proteins L26 eukaryotic, L24P archaeal
171 RPS3interactor410.332171.650KH_2 (PF07650, IPR004044): KH domain
Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
172 RPS6KB2interactor280.34979.523Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
173 RSBN1interactor208.948NA
174 RSBN1Linteractor205.746Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
175 SDAD1interactor40.6678.310DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
NUC130_3NT (PF08158, IPR012977): NUC130/3NT domain
SDA1 (PF05285, IPR007949): SDA1
YL1 (PF05764, IPR008895): YL1 nuclear protein
176 SEC31Binteractor90.9170.731SRA1 (PF07304, IPR009917): Steroid receptor RNA activator (SRA1)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
177 SF3B3interactor220.48942.979CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
178 SHC1oncoprotein220.41449.765PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
179 SIRT1suppressor140.385121.927DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
180 SIRT7interactor380.233339.005DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
181 SMURF1interactor210.45818.086C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
182 SNW1protein found in more fusions520.311814.105SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
183 SPTY2D1interactor3012.215SPT2 (PF08243, IPR013256, SM00784): SPT2 chromatin protein
Usp (PF00582, IPR006016): Universal stress protein family
184 SRPK1interactor150.352124.732FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
185 SSR1interactor110.7642.177TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
186 SSSCA1interactor70.5332.268Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)
187 STAU1protein found in more fusions310.370557.534dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
188 STK24interactor190.71218.822DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
189 STRNoncoprotein170.8539.394CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Nucleoporin_N (PF08801, IPR014908): Nup133 N terminal like
Striatin (PF08232, IPR013258): Striatin family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
190 STRN3interactor170.82411.098Striatin (PF08232, IPR013258): Striatin family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
191 TCF3suppressor40.33333.251CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
192 TCOF1interactor80.14334.506CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Gal-3-0_sulfotr (PF06990, IPR009729): Galactose-3-O-sulfotransferase
Treacle (PF03546, IPR003993): Treacher Collins syndrome protein Treacle
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
AP3D1 (PF06375): AP-3 complex subunit delta-1
193 TCP1interactor1110.1912038.413Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
194 TP53suppressor690.2611250.565DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
195 TRIM26protein found in more fusions50.16739.436Nop14 (PF04147, IPR007276): Nop14-like family
SPRY (PF00622, IPR003877, SM00449): SPRY domain
IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
196 TRIM28protein found in more fusions410.341502.704ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
197 TRIM41interactor50.333152.256BUD22 (PF09073, IPR015158): BUD22
Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
RecR (PF02132, IPR023628): RecR protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3631 (PF12307, IPR022081): Protein of unknown function (DUF3631)
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
198 TSGA10interactor4016.516Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Pox_A3L (PF05288, IPR007952): Poxvirus A3L Protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
199 TSSK6interactor100.7331.111Pkinase (PF00069, IPR000719): Protein kinase domain
200 TTLL3oncoprotein71.0000TTL (PF03133, IPR004344): Tubulin-tyrosine ligase family
201 TUBA1Binteractor200.40527.572Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
202 TUBA1Cinteractor370.52166.219Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
203 TUBA3Einteractor60.8670.458Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
204 TUBAL3interactor80.7141.814Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
205 TUBBinteractor510.296479.103Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
206 TUBB2Ainteractor200.30044.669Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
207 TUBB2Binteractor200.51135.306Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
208 TUBG1protein found in more fusions320.53176.224Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
209 TXNL1interactor90.7222.056PITH (PF06201, IPR010400): PITH domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
210 TYK2interactor150.57191.689Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
211 U2AF2protein found in more fusions340.462103.033RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
212 UBCprotein found in more fusions580.294874.879ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
213 VAV2oncoprotein80.50023.175PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
CotJB (PF12652, IPR024207): CotJB protein
214 VCAM1interactor310.47745.260C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
215 VCPprotein found in more fusions630.368488.458AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
216 VHLsuppressor270.52381.040Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
217 VRK2interactor60.8670.411Pkinase (PF00069, IPR000719): Protein kinase domain
VP_N-CPKC (PF11475, IPR021573): Virion protein N terminal domain
218 WDR76interactor80.8210.491WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
SPATIAL (PF15256): SPATIAL
219 WDR83interactor110.8365.571WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
220 WRAP53oncoprotein100.9780.222WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
221 WRAP73interactor70.4674.053eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
IKI3 (PF04762, IPR006849): IKI3 family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2555 (PF10742, IPR019678): Protein of unknown function (DUF2555)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
222 WWOXsuppressor170.33194.469adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
223 XIAPinteractor70.4007.049BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
224 YTHDC2interactor90.36152.894DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
R3H (PF01424, IPR001374, SM00393): R3H domain
YTH (PF04146, IPR007275): YT521-B-like domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_23 (PF13476): AAA domain
225 ZCCHC17interactor100S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
226 ZNF689interactor205.969A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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