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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SLC34A2, ZBTB43 (from a repository: Thu Nov 21 02:23:17 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins5 (17.86 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)40 (10.58 %)
The number (and %) of affected PPIs27 (67.50 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI2.357
Assortativity coefficient-0.5334
The network average Clustering coefficient0.275
The number (and %) of a zero Clustering coefficients18 (64.29 %)
The number (and %) of a zero Betweenness Centrality24 (85.71 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ZBTB43,SLC34A2 All fusions
Proteins found in more fusions ARSA (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ZBTB43parental protein260.023579.000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF2256 (PF10013, IPR017136): Uncharacterized protein conserved in bacteria (DUF2256)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_8 (PF15909, IPR031799): C2H2-type zinc ribbon
2 SLC34A2parental protein100TMEM43 (PF07787, IPR012430): Transmembrane protein 43
Na_Pi_cotrans (PF02690, IPR003841): Na+/Pi-cotransporter
SKG6 (PF08693, IPR014805): Transmembrane alpha-helix domain
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
3 AENinteractor100RNase_T (PF00929, IPR013520): Exonuclease
4 AP1M1interactor100Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
5 ARR3interactor21.0000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
6 ARRB1interactor21.0000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
7 ARSAprotein found in more fusions200Sulfatase (PF00884, IPR000917): Sulfatase
Sulfatase_C (PF14707): C-terminal region of aryl-sulfatase
DUF4976 (PF16347, IPR032506): Domain of unknown function (DUF4976)
8 BDP1interactor100SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
DUF2917 (PF11142, IPR021317): Protein of unknown function (DUF2917)
UPF0542 (PF15086, IPR027877): Uncharacterised protein family UPF0542
Myb_DNA-bind_7 (PF15963): Myb DNA-binding like
9 DIP2Ainteractor100AMP-binding (PF00501, IPR000873): AMP-binding enzyme
Cornifin (PF02389, IPR003302): Cornifin (SPRR) family
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
10 EIF4A1interactor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
11 ELAVL1oncoprotein50.5003.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12 FAM161Ainteractor200YajC (PF02699, IPR003849): Preprotein translocase subunit
UPF0564 (PF10595, IPR019579): Uncharacterised protein family UPF0564
13 LAMTOR3interactor30.6671.000MAPKK1_Int (PF08923, IPR015019): Mitogen-activated protein kinase kinase 1 interacting
14 LMO1oncoprotein100LIM (PF00412, IPR001781, SM00132): LIM domain
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
15 LMO3oncoprotein100LIM (PF00412, IPR001781, SM00132): LIM domain
16 LMO4interactor100LIM (PF00412, IPR001781, SM00132): LIM domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
17 LNX1interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
18 MARCKSL1oncoprotein21.0000MARCKS (PF02063, IPR002101): MARCKS family
19 MCM10interactor100Mcm10 (PF09332, IPR015411): Mcm10 replication factor
zf-primase (PF09329, IPR015408): Primase zinc finger
AATF-Che1 (PF13339, IPR025160): Apoptosis antagonizing transcription factor
20 MORF4L2interactor100MRG (PF05712, IPR026541): MRG
21 MSLNinteractor21.0000Mesothelin (PF06060, IPR010335): Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)
22 NUDCD1interactor100CS (PF04969, IPR007052): CS domain
23 PSMD3interactor100Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
24 SYT6interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
25 TCEB3Binteractor21.0000Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
FAM176 (PF14851): FAM176 family
26 TRAF2interactor50.5003.000MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
27 ZBTB24interactor100AT_hook (PF02178, IPR017956, SM00384): AT hook motif
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zinc_ribbon_4 (PF13717): zinc-ribbon domain
28 ZNF417interactor100A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain
C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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