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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RASA1, LINC02237 (from a repository: Sun Jul 28 07:19:51 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins27 (50.94 %)
The number (and %) of the tumor suppressors10 (18.87 %)
Total number of binary PPIs (saturation %)249 (18.07 %)
The number (and %) of affected PPIs51 (20.48 %)
The number of possible different fusions13
PPI diameter2
PPI radiusinf
The average degree of PPI8.566
Assortativity coefficient-0.2009
The network average Clustering coefficient0.512
The number (and %) of a zero Clustering coefficients6 (11.32 %)
The number (and %) of a zero Betweenness Centrality11 (20.75 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RASA1,LINC02237 All fusions
Proteins found in more fusions ERBB3 (see 2 fusions); APP (see 5 fusions); KHDRBS1 (see 1 fusions); EZH2 (see 1 fusions); GRB2 (see 1 fusions); G3BP1 (see 1 fusions); LCK (see 1 fusions); PTK2B (see 1 fusions); EGFR (see 2 fusions); RACK1 (see 3 fusions); EPHB2 (see 1 fusions); HTT (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RASA1parental protein510.1381448.944C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
2 LINC02237interactor000NA
3 ABL1oncoprotein210.38470.237Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4 ANXA6interactor30.6670.250Annexin (PF00191, IPR018502, SM00335): Annexin
5 APPprotein found in more fusions100.38916.300APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ARHGAP35oncoprotein31.0000FF (PF01846, IPR002713, SM00441): FF domain
Ras (PF00071, IPR001806, SM00173): Ras family
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RhoGAP-FF1 (PF16512, IPR032835): p190-A and -B Rho GAPs FF domain
7 BBS10interactor100Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
8 BTRConcoprotein60.4005.667WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
9 CAV2interactor40.8330.200Caveolin (PF01146, IPR001612): Caveolin
10 CD5interactor31.0000SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
Comm (PF15957, IPR031878): Commissureless
11 CSKinteractor110.49113.220Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
12 DNAJA3suppressor40.6670.833DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
13 DOK1suppressor130.57611.643IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
14 DOK2suppressor60.7332.133IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
15 EGFRoncoprotein270.314136.427Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
16 EIF1interactor21.0000SUI1 (PF01253, IPR001950): Translation initiation factor SUI1
17 EPHB2suppressor60.7001.067EGF_2 (PF07974, IPR013111): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
18 EPHB3suppressor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
19 ERBB2oncoprotein140.55118.346Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
20 ERBB3oncoprotein120.7094.924Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
21 ERBB4suppressor70.9330.250Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
22 EZH2suppressor50.5002.400CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
23 G3BP1protein found in more fusions60.4002.717NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
24 GRB2oncoprotein250.348106.085SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
25 HCKoncoprotein90.5288.366Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
26 HRASoncoprotein30.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
27 HTTprotein found in more fusions50.6671.000HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
28 IGF1Roncoprotein100.42213.752fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
29 INSRinteractor100.44414.221fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
30 KDRoncoprotein50.7002.667Ehrlichia_rpt (PF09528, IPR019048): Ehrlichia tandem repeat (Ehrlichia_rpt)
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
31 KHDRBS1protein found in more fusions130.37922.443KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
32 LCKoncoprotein110.26721.300Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
33 MAP4K4interactor30.6670.286CNH (PF00780, IPR001180, SM00036): CNH domain
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Pkinase (PF00069, IPR000719): Protein kinase domain
FAM165 (PF14981, IPR028023): FAM165 family
SOBP (PF15279, IPR026092): Sine oculis-binding protein
FAM60A (PF15396, IPR026065): Protein Family FAM60A
34 NCK1oncoprotein150.36237.656SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
35 NFKBIAoncoprotein70.4298.067Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
36 NTRK1oncoprotein170.34256.287I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
37 OLIG1interactor50.5001.736HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
38 PDGFRBoncoprotein80.8570.736I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
TonB_N (PF16031): TonB N-terminal region
39 PLCG1oncoprotein160.50028.128C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
40 PTK2Bprotein found in more fusions90.6434.219FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
41 PXNoncoprotein80.5365.038LIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
42 RACK1suppressor70.6003.686WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
43 SERPINA4interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
44 SLC9A2oncoprotein31.0000Na_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
45 SOCS1suppressor90.5566.238SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
46 SOCS3suppressor100.40015.469SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
47 SPSB1interactor100SPRY (PF00622, IPR003877, SM00449): SPRY domain
SOCS_box (PF07525, IPR001496): SOCS box
48 SRConcoprotein220.35779.675Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
49 TRMT2Ainteractor31.0000PCMT (PF01135, IPR000682): Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
tRNA_U5-meth_tr (PF05958, IPR010280): tRNA (Uracil-5-)-methyltransferase
Methyltransf_31 (PF13847, IPR025714): Methyltransferase domain
Hepar_II_III_N (PF16889, IPR031680): Heparinase II/III N-terminus
50 XRCC6oncoprotein50.6671.000Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain
51 YES1oncoprotein80.3579.539Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
YdjC (PF04794, IPR006879): YdjC-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
52 ZAP70interactor110.53313.850Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
53 ZNF579interactor100SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
Anti-TRAP (PF15777, IPR031538): Tryptophan RNA-binding attenuator protein inhibitory protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger

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