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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DEAF1, KLK5 (from a repository: Thu Nov 17 12:29:53 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)68
The number (and %) of the onco-proteins15 (22.06 %)
The number (and %) of the tumor suppressors14 (20.59 %)
Total number of binary PPIs (saturation %)135 (5.93 %)
The number (and %) of affected PPIs66 (48.89 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI3.559
Assortativity coefficient-0.5103
The network average Clustering coefficient0.280
The number (and %) of a zero Clustering coefficients34 (50.00 %)
The number (and %) of a zero Betweenness Centrality40 (58.82 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions OS9 (see 2 fusions); CDC37 (see 2 fusions); CREB1 (see 2 fusions); AIMP2 (see 1 fusions); GSK3B (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DEAF1parental protein210.0481167.379Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAND (PF01342, IPR000770, SM00258): SAND domain
zf-MYND (PF01753, IPR002893): MYND finger
2 KLK5parental protein450.0203237.524Trypsin (PF00089, IPR001254, SM00020): Trypsin
3 AIMP2suppressor200GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
AIMP2_LysRS_bd (PF16780, IPR031889): AIMP2 lysyl-tRNA synthetase binding domain
4 AP3S1interactor100Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
5 ASCC2interactor100CUE (PF02845, IPR003892, SM00546): CUE domain
BLOC1S3 (PF15753, IPR017245): Biogenesis of lysosome-related organelles complex 1 subunit 3
6 AURKAoncoprotein90.214300.061Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
7 BAG4interactor21.0000BAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
8 BBS7interactor100ZapB (PF06005, IPR009252): Cell division protein ZapB
FlxA (PF14282, IPR025577): FlxA-like protein
BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
Itfg2 (PF15907, IPR031793): Integrin-alpha FG-GAP repeat-containing protein 2
9 C21orf59interactor100BRX (PF08381, IPR013591): Transcription factor regulating root and shoot growth via Pin3
DUF2870 (PF11069, IPR021298): Protein of unknown function (DUF2870)
10 CASP8suppressor200DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
11 CBWD1interactor40.5008.038cobW (PF02492, IPR003495): CobW/HypB/UreG, nucleotide-binding domain
CobW_C (PF07683, IPR011629, SM00833): Cobalamin synthesis protein cobW C-terminal domain
12 CCND3oncoprotein40.167133.582Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
13 CDC37protein found in more fusions4073.481CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
14 CDKN1Asuppressor70.238197.510CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
15 CDKN2Asuppressor50.300133.881Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
16 CELSR2interactor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
Cadherin_3 (PF16184): Cadherin-like
GAIN (PF16489, IPR032471): GPCR-Autoproteolysis INducing (GAIN) domain
17 CERCAMinteractor21.0000Glyco_transf_25 (PF01755, IPR002654): Glycosyltransferase family 25 (LPS biosynthesis protein)
Glyco_tranf_2_4 (PF13704): Glycosyl transferase family 2
18 CHD1Linteractor100ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
19 COX11interactor100CtaG_Cox11 (PF04442, IPR007533): Cytochrome c oxidase assembly protein CtaG/Cox11
UCR_Fe-S_N (PF10399, IPR019470): Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal
20 CPNE1interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
Copine (PF07002, IPR010734): Copine
21 CREB1oncoprotein50.66717.758bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
22 EME1interactor21.0000ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
23 ERBB2oncoprotein80.286201.175Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
24 ESR1suppressor110.156416.752Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
25 FHL1suppressor2030.803LIM (PF00412, IPR001781, SM00132): LIM domain
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
26 FRAS1interactor100Calx-beta (PF03160, IPR003644, SM00237): Calx-beta domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
VSP (PF03302, IPR005127): Giardia variant-specific surface protein
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
TMEM154 (PF15102, IPR028064): TMEM154 protein family
Furin-like_2 (PF15913, IPR006212): Furin-like repeat, cysteine-rich
Cadherin_3 (PF16184): Cadherin-like
27 FREM2interactor100Calx-beta (PF03160, IPR003644, SM00237): Calx-beta domain
Cadherin_3 (PF16184): Cadherin-like
28 FUKinteractor100Fucokinase (PF07959, IPR012887): L-fucokinase
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
29 GSK3Ainteractor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
30 GSK3Bsuppressor80.238177.099Pkinase (PF00069, IPR000719): Protein kinase domain
31 HRASoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
32 IGF1Roncoprotein40.8331.789fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
33 IRF3suppressor50.333118.967IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
34 IRF7interactor31.0000IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
35 ITGB5interactor100EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
36 KIAA1147oncoprotein100Baculo_LEF-11 (PF06385, IPR009429): Baculovirus LEF-11 protein
DUF2347 (PF09804, IPR018626): Uncharacterized conserved protein (DUF2347)
37 LMO4interactor30.33332.289LIM (PF00412, IPR001781, SM00132): LIM domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
38 LOXL2oncoprotein100Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
Lysyl_oxidase (PF01186, IPR001695): Lysyl oxidase
SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
39 MCM8interactor100MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_OB (PF17207): MCM OB domain
40 METTL13interactor100Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
Methyltransf_23 (PF13489): Methyltransferase domain
41 MKS1interactor100B9-C2 (PF07162, IPR010796): Ciliary basal body-associated, B9 protein
42 NAT2oncoprotein60.40079.086Acetyltransf_2 (PF00797, IPR001447): N-acetyltransferase
43 ND1interactor100NA
44 NEU3oncoprotein100BNR (PF02012, IPR002860): BNR/Asp-box repeat
BNR_2 (PF13088, IPR011040): BNR repeat-like domain
45 NOTCH2suppressor2053.981Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
46 OS9protein found in more fusions31.0000DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
47 PASKinteractor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
PAS_8 (PF13188, IPR000014): PAS domain
PAS_9 (PF13426, IPR000014): PAS domain
48 PCinteractor30.6672.333Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
HMGL-like (PF00682, IPR000891): HMGL-like
PYC_OADA (PF02436, IPR003379): Conserved carboxylase domain
49 PCDH7interactor100Cadherin_2 (PF08266, IPR013164): Cadherin-like
Protocadherin (PF08374, IPR013585): Protocadherin
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
Cadherin_3 (PF16184): Cadherin-like
50 PELI1interactor100Pellino (PF04710, IPR006800): Pellino
51 PELI2interactor100Pellino (PF04710, IPR006800): Pellino
52 PIN1suppressor30.33349.070Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
53 POLE2interactor100DNA_pol_E_B (PF04042, IPR007185): DNA polymerase alpha/epsilon subunit B
Dpoe2NT (PF12213, IPR024639): DNA polymerases epsilon N terminal
54 PPP1CAsuppressor70.381146.908Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
55 PPP1CConcoprotein60.40095.822Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
56 RAD23Bsuppressor100K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
57 RIDAinteractor200Ribonuc_L-PSP (PF01042, IPR006175): Endoribonuclease L-PSP
58 TGFB1suppressor100TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
59 TK1oncoprotein50.66771.204TK (PF00265, IPR001267, SM00203): Thymidine kinase
60 TRMT44interactor100AdoMet_MTase (PF07757, IPR011671): Predicted AdoMet-dependent methyltransferase
61 TSG101suppressor3033.785APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
62 TTC5interactor21.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
Abi_C (PF14355, IPR026001): Abortive infection C-terminus
TTC5_OB (PF16669, IPR032076): Tetratricopeptide repeat protein 5 OB fold domain
63 TUBA1Aoncoprotein90.250269.798Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
64 TUBA4Ainteractor40.6678.322Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
65 TUBB3interactor50.60098.702Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
66 TUBB4Ainteractor21.0000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
67 TUBB8interactor30.333162.900Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
68 VWA9interactor21.0000VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain

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