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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)140
The number (and %) of the onco-proteins32 (22.86 %)
The number (and %) of the tumor suppressors23 (16.43 %)
Total number of binary PPIs (saturation %)736 (7.56 %)
The number (and %) of affected PPIs138 (18.75 %)
The number of possible different fusions24
PPI diameter5
PPI radius3
The average degree of PPI9.857
Assortativity coefficient-0.1983
The network average Clustering coefficient0.452
The number (and %) of a zero Clustering coefficients14 (10.00 %)
The number (and %) of a zero Betweenness Centrality27 (19.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: YAP1,ITGA2 All fusions
Proteins found in more fusions SRSF2 (see 1 fusions); YWHAG (see 1 fusions); UBE2C (see 1 fusions); SLC9A3R1 (see 2 fusions); COL1A1 (see 11 fusions); CREB1 (see 2 fusions); YWHAH (see 2 fusions); RUNX1 (see 1 fusions); NF2 (see 1 fusions); LGALS3 (see 2 fusions); AHCYL1 (see 3 fusions); PRDX1 (see 1 fusions); YWHAZ (see 1 fusions); EGFR (see 2 fusions); UBQLN2 (see 2 fusions); STUB1 (see 1 fusions); POLR2A (see 2 fusions); AMOTL2 (see 1 fusions); EP300 (see 1 fusions); PML (see 4 fusions); STAT1 (see 1 fusions); SMAD3 (see 3 fusions); YWHAZ/PARD3 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 YAP1parental protein1200.07211303.787Bindin (PF02084, IPR000775): Bindin
WW (PF00397, IPR001202, SM00456): WW domain
GspL_C (PF12693, IPR025691): GspL periplasmic domain
FAM181 (PF15238, IPR029359): FAM181
2 ITGA2parental protein180.0652056.326FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
3 ABL1oncoprotein180.368116.100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4 AHCYL1suppressor200.357158.559AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
5 ALBinteractor30.33358.554Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
6 AMOToncoprotein180.41959.063FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP)
Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family
DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162)
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
7 AMOTL1interactor90.52811.886NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Presenilin (PF01080, IPR001108): Presenilin
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
8 AMOTL2protein found in more fusions130.56112.871HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
9 ARFIP1interactor30.6670.667Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
10 ARID1Asuppressor100.31138.014ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
YscJ_FliF_C (PF08345, IPR013556): Flagellar M-ring protein C-terminal
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
11 ARID1Boncoprotein41.0000ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Presenilin (PF01080, IPR001108): Presenilin
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
DUF2235 (PF09994, IPR018712): Uncharacterized alpha/beta hydrolase domain (DUF2235)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa
Spt20 (PF12090, IPR021950): Spt20 family
12 ARRDC1interactor30.6670.286Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
13 ATF2oncoprotein130.136696.721bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
14 ATPIF1interactor21.0000DivIC (PF04977, IPR007060): Septum formation initiator
IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
15 AUP1interactor2068.680CUE (PF02845, IPR003892, SM00546): CUE domain
16 BCL9Linteractor100BCL9 (PF11502, IPR024670): B-cell lymphoma 9 protein
17 BTNL8interactor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Ig_3 (PF13927): Immunoglobulin domain
18 BTRConcoprotein230.229246.589WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
19 CCDC85Cinteractor50.7000.783bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CCDC85 (PF10226, IPR019359): CCDC85 family
20 CD46oncoprotein21.0000Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
DUF3188 (PF11384, IPR021524): Protein of unknown function (DUF3188)
ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator
21 COL1A1oncoprotein40.667108.525COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EKLF_TAD1 (PF16832, IPR031786): Erythroid krueppel-like transcription factor, transactivation 1
22 CPVLinteractor50.5003.820Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
23 CREB1oncoprotein70.46736.071bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
24 CYYR1interactor100CYYR1 (PF10873, IPR022640): Cysteine and tyrosine-rich protein 1
25 DPF2interactor41.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ.
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
Zf_RING (PF16744, IPR031946): KIAA1045 RING finger
26 EGFRoncoprotein280.151932.176Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
27 ELAVL1oncoprotein290.156900.029RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
28 ENO1oncoprotein100.22296.705Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
29 EP300oncoprotein210.242189.777Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
30 ERBB4suppressor50.8330.500Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
31 ERGIC1interactor100COPIIcoated_ERV (PF07970, IPR012936): Endoplasmic reticulum vesicle transporter
ERGIC_N (PF13850): Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
32 ERP44interactor30.6670.404Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
33 FAM189Binteractor21.0000CD20 (PF04103, IPR007237): CD20-like family
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
34 FASNinteractor40.6671.000Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ketoacyl-synt (PF00109, IPR014030): Beta-ketoacyl synthase, N-terminal domain
Ketoacyl-synt_C (PF02801, IPR014031): Beta-ketoacyl synthase, C-terminal domain
KR (PF08659, IPR013968, SM00130): KR domain
L27 (PF02828, IPR014775, SM00569): L27 domain
Methyltransf_12 (PF08242, IPR013217): Methyltransferase domain
PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site
Thioesterase (PF00975, IPR001031): Thioesterase domain
YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
PS-DH (PF14765, IPR020807): Polyketide synthase dehydratase
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
35 FBXW11interactor140.397307.006WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
36 FBXW7suppressor110.24423.144Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
37 HSPA4interactor160.275128.718Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
38 HSPA4Linteractor40.6671.167HSP70 (PF00012, IPR013126): Hsp70 protein
39 HSPH1oncoprotein60.40043.307HSP70 (PF00012, IPR013126): Hsp70 protein
SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain
40 HYOU1interactor40.5002.450HSP70 (PF00012, IPR013126): Hsp70 protein
AbiEi_3_N (PF17194): Transcriptional regulator, AbiEi antitoxin N-terminal domain
41 IGBP1interactor110.345142.115TAP42 (PF04177, IPR007304): TAP42-like family
42 ITCHinteractor260.147277.018C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
43 ITGB1suppressor110.255657.983EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin beta chain VWA domain
PSI_integrin (PF17205): Integrin plexin domain
44 KIF5Ainteractor40.5002.500ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
Microtub_bd (PF16796, IPR031852): Microtubule binding
45 KLF5suppressor70.3819.516zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
46 LAMA1interactor31.0000Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
Laminin_II (PF06009, IPR010307): Laminin Domain II
Sec34 (PF04136, IPR007265): Sec34-like family
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
47 LATS1suppressor120.47019.338Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
48 LATS2suppressor220.329118.408Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
49 LDLRAD4interactor31.0000Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615)
50 LGALS3oncoprotein60.300188.842Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
51 LGALS8interactor30.33365.530Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
52 LIN7Cinteractor100.64417.505His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2)
L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
53 MAP2K1oncoprotein70.8670.854Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216)
54 MCMBPinteractor50.4004.344MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor
55 MMP1interactor100FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Peptidase_M10 (PF00413, IPR001818): Matrixin
PG_binding_1 (PF01471, IPR002477): Putative peptidoglycan binding domain
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
56 MOV10interactor160.18369.123AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
57 MPDZinteractor80.6078.657L27_2 (PF09045, IPR015132): L27_2
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
58 MPP5interactor90.7783.052L27 (PF02828, IPR014775, SM00569): L27 domain
L27_N (PF09060, IPR015145): L27_N
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
59 NEDD8interactor150.29795.644ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
60 NF2suppressor160.29564.600ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
61 NFE2interactor40.6670.286bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
Peptidase_Mx (PF15887, IPR031321): Putative zinc-binding metallo-peptidase
62 NUBP2interactor90.38963.181ParA (PF10609, IPR019591): NUBPL iron-transfer P-loop NTPase
63 NXF1interactor230.160137.699NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
64 PAPOLAinteractor21.0000PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain
Macoilin (PF09726, IPR019130): Transmembrane protein
65 PARD3protein found in more fusions170.41962.084PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
66 PATJoncoprotein80.8571.352L27_2 (PF09045, IPR015132): L27_2
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
67 PDIA3interactor60.267172.582Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
68 PDLIM7interactor31.0000LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
69 PIN1suppressor100.35622.698Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
70 PMLsuppressor120.34583.016zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
71 POLR2Aprotein found in more fusions140.30842.428RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
72 PPP1CAsuppressor110.41821.744Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
73 PRDX1oncoprotein100.36123.349AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
74 PRMT3interactor60.53312.171PrmA (PF06325, IPR010456): Ribosomal protein L11 methyltransferase (PrmA)
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
75 PRRG2interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Gla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
76 PRRG4interactor100Gla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
77 PSMD4interactor120.197735.899UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
78 PTCH1suppressor31.0000Patched (PF02460, IPR003392): Patched family
79 PTPN14oncoprotein70.5715.211FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
80 RABIFinteractor100Mss4 (PF04421, IPR007515): Mss4 protein
DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit
81 RAE1interactor70.4767.326Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
82 RAPGEF2interactor50.5005.868PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
83 RAPGEF6interactor60.4003.884PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
84 RASSF8suppressor90.61155.280ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region
FliD_C (PF07195, IPR010809): Flagellar hook-associated protein 2 C-terminus
PEARLI-4 (PF05278, IPR007942): Arabidopsis phospholipase-like protein (PEARLI 4)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
85 RSRP1oncoprotein100RSRP (PF17069): Arginine/Serine-Rich protein 1
86 RTF1interactor21.0000K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Plus-3 (PF03126, IPR004343): Plus-3 domain
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
YL1 (PF05764, IPR008895): YL1 nuclear protein
AAA_23 (PF13476): AAA domain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
87 RUNX1suppressor90.6436.320Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
88 RUNX2suppressor80.6075.499DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Runt (PF00853, IPR013524): Runt domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
89 RUNX3suppressor70.7622.022Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
90 SCAMP3interactor31.0000SCAMP (PF04144, IPR007273): SCAMP family
91 SHARPINinteractor200DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Sharpin_PH (PF16764, IPR031912): Sharpin PH domain
92 SLC9A3R1suppressor70.46759.899EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
93 SLC9A3R2interactor21.0000EBP50_C (PF09007, IPR015098): EBP50, C-terminal
GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
94 SMAD1interactor150.42930.727MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
95 SMAD3oncoprotein240.245273.665MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
96 SMAD5interactor110.56417.213MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
97 SMAD6interactor60.6674.017MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
98 SMAD7interactor80.5716.168MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
99 SMARCD1interactor60.53310.747ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
DivIC (PF04977, IPR007060): Septum formation initiator
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
100 SRSF2oncoprotein90.4649.211RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
Transformer (PF06495, IPR010519): Fruit fly transformer protein
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
101 STAT1suppressor110.28940.695SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
102 STUB1suppressor210.253195.554U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
103 SULT1A1interactor100.51116.346Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
104 SUMO1interactor90.32156.038Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
105 TEAD1interactor21.0000TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
106 TEAD2interactor50.4007.352TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
107 TEAD3interactor50.5005.060TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
108 TEAD4interactor40.5002.500TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
109 THUMPD1interactor100THUMP (PF02926, IPR004114, SM00981): THUMP domain
110 TJP2oncoprotein100.46718.489PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
111 TOM1oncoprotein30.6670.400GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
112 TP53BP2suppressor200.29598.127ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Erp_C (PF06780, IPR009618): Erp protein C-terminus
SlyX (PF04102, IPR007236): SlyX
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
113 TP63suppressor90.4647.949Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
114 TP73suppressor80.3817.470P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
115 TSNAXinteractor50.4004.333Translin (PF01997, IPR002848): Translin family
116 TTC9Cinteractor70.7142.205TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
117 UBA2interactor120.34836.098ThiF (PF00899, IPR000594): ThiF family
UAE_UbL (PF14732, IPR028077): Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
118 UBE2Concoprotein100.50052.477UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
119 UBE2D1interactor150.36343.621UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
120 UBE2L3interactor140.41030.732UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
121 UBQLN2protein found in more fusions70.6003.941Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SUZ (PF12752, IPR024771): SUZ domain
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
122 UBXN7interactor120.48515.786UBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
123 UCHL3interactor130.42424.319Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
124 UFM1interactor90.7225.803Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
125 UNKinteractor200.221422.770MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
126 USP9Xinteractor200.32697.725DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
127 VPS25interactor200ESCRT-II (PF05871, IPR008570): ESCRT-II complex subunit
128 VPS4Binteractor90.41718.665AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
129 WBP1interactor40.6671.619WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
130 WBP2interactor30.6670.400GRAM (PF02893, IPR004182, SM00568): GRAM domain
Vps36_ESCRT-II (PF11605, IPR021648): Vacuolar protein sorting protein 36 Vps36
131 XPO1interactor300.175362.133CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
132 YWHABinteractor210.352349.00114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
133 YWHAEoncoprotein200.38490.13114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
134 YWHAGprotein found in more fusions210.379376.27914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
135 YWHAHprotein found in more fusions160.56226.19714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
136 YWHAQinteractor160.41763.26514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
137 YWHAZprotein found in more fusions260.307147.83614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
138 ZACNinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
139 ZFYVE19interactor160.45036.007Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
140 ZPR1interactor100.48912.417zf-ZPR1 (PF03367, IPR004457, SM00709): ZPR1 zinc-finger domain

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