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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins YPEL5, CEPT1 (from a repository: Wed Dec 11 13:00:57 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)31
The number (and %) of the onco-proteins6 (19.35 %)
The number (and %) of the tumor suppressors1 (3.23 %)
Total number of binary PPIs (saturation %)52 (11.18 %)
The number (and %) of affected PPIs30 (57.69 %)
The number of possible different fusions2
PPI diameter4
PPI radius2
The average degree of PPI2.968
Assortativity coefficient-0.3580
The network average Clustering coefficient0.461
The number (and %) of a zero Clustering coefficients12 (38.71 %)
The number (and %) of a zero Betweenness Centrality23 (74.19 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CEPT1,YPEL5 All fusions
Proteins found in more fusions MYC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CEPT1parental protein190.041634.333CDP-OH_P_transf (PF01066, IPR000462): CDP-alcohol phosphatidyltransferase
2 YPEL5parental protein110.145378.333Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
3 ADCYAP1interactor100Hormone_2 (PF00123, IPR000532, SM00070): Peptide hormone
4 CDC42oncoprotein50.50021.667Ras (PF00071, IPR001806, SM00173): Ras family
5 CHST15interactor100Sulfotransfer_3 (PF13469): Sulfotransferase family
6 CSNK2A2interactor2064.667Pkinase (PF00069, IPR000719): Protein kinase domain
7 ELAVL1oncoprotein50.333332.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 GDNFinteractor21.0000TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
9 GPS2oncoprotein21.0000G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
10 HIST1H3Einteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
11 HLA-DPB1interactor21.0000MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
12 IQGAP1interactor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
13 KIF22interactor100Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
HHH_3 (PF12836): Helix-hairpin-helix motif
14 MRPL4interactor31.0000Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
15 MYConcoprotein31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
16 MYH14interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
17 OAZ1interactor100ODC_AZ (PF02100, IPR002993): Ornithine decarboxylase antizyme
18 PRG2interactor21.0000Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF4628 (PF15429, IPR027851): Domain of unknown function (DUF4628)
19 PSMC1interactor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
20 QSOX2interactor100Zn-ribbon_8 (PF09723, IPR013429, SM00834): Zinc ribbon domain
Evr1_Alr (PF04777, IPR017905): Erv1 / Alr family
Thioredoxin (PF00085, IPR013766): Thioredoxin
zf-HYPF (PF07503, IPR011125): HypF finger
Thioredoxin_2 (PF13098, IPR012336): Thioredoxin-like domain
21 RMND5Ainteractor80.28625.000CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
SnoaL_4 (PF13577, IPR009959): SnoaL-like domain
22 SLC33A1interactor100Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
23 SMC6interactor200SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
24 SOX2oncoprotein50.50050.667HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
25 TDGF1suppressor21.0000CFC (PF09443, IPR019011): Cripto_Frl-1_Cryptic (CFC)
EGF (PF00008, IPR000742, SM00181): EGF-like domain
26 TOMM40interactor21.0000Porin_3 (PF01459, IPR027246): Eukaryotic porin
27 UGGT1interactor21.0000Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
UDP-g_GGTase (PF06427, IPR009448): UDP-glucose:Glycoprotein Glucosyltransferase
28 VAPAinteractor40.5003.000DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
29 WDR62interactor200eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
30 XRCC3oncoprotein100Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
31 YIPF5interactor21.0000Yip1 (PF04893, IPR006977): Yip1 domain

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