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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ABCA8, CDK17 (from a repository: Thu May 10 05:09:46 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins9 (33.33 %)
The number (and %) of the tumor suppressors2 (7.41 %)
Total number of binary PPIs (saturation %)67 (19.09 %)
The number (and %) of affected PPIs25 (37.31 %)
The number of possible different fusions7
PPI diameter2
PPI radiusinf
The average degree of PPI4.222
Assortativity coefficient-0.4102
The network average Clustering coefficient0.481
The number (and %) of a zero Clustering coefficients8 (29.63 %)
The number (and %) of a zero Betweenness Centrality13 (48.15 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ABCA8,CDK17 All fusions
Proteins found in more fusions PPP2R5E (see 1 fusions); APP (see 4 fusions); GAPDH (see 3 fusions); YWHAG (see 1 fusions); DHPS (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ABCA8interactor000ABC2_membrane (PF01061, IPR013525): ABC-2 type transporter
ABC_tran (PF00005, IPR003439): ABC transporter
RseC_MucC (PF04246, IPR007359): Positive regulator of sigma(E), RseC/MucC
ABC2_membrane_3 (PF12698): ABC-2 family transporter protein
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
DUF4162 (PF13732, IPR025302): Domain of unknown function (DUF4162)
2 CDK17parental protein250.107472.800Pkinase (PF00069, IPR000719): Protein kinase domain
3 APPprotein found in more fusions80.4769.567APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 BAG3oncoprotein60.7003.000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
5 C12orf43interactor21.0000RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
6 CDK1oncoprotein40.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
7 CDK14interactor200Pkinase (PF00069, IPR000719): Protein kinase domain
TruB_C_2 (PF16198, IPR032819): tRNA pseudouridylate synthase B C-terminal domain
8 CDK16oncoprotein80.5369.400Pkinase (PF00069, IPR000719): Protein kinase domain
9 DHPSprotein found in more fusions200DS (PF01916, IPR002773): Deoxyhypusine synthase
10 EPHA2suppressor31.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
11 FEM1Ainteractor100Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
TPR_12 (PF13424): Tetratricopeptide repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
12 GAPDHoncoprotein60.6002.233Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
13 MMS19interactor21.0000DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
14 NOP10interactor100Nop10p (PF04135, IPR007264): Nucleolar RNA-binding protein, Nop10p family
15 PPP2CBsuppressor40.6671.667Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
16 PPP2R2Ainteractor50.6002.733WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
17 PPP2R3Ainteractor100EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
DUF3924 (PF13062, IPR025038): Protein of unknown function (DUF3924)
DUF4116 (PF13475, IPR025197): Domain of unknown function (DUF4116)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
DUF4187 (PF13821, IPR025239): Domain of unknown function (DUF4187)
18 PPP2R5Eprotein found in more fusions40.6670.667B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
19 PRKACGinteractor100Pkinase (PF00069, IPR000719): Protein kinase domain
20 PTMAoncoprotein21.0000Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
21 SUGP1interactor21.0000G-patch (PF01585, IPR000467, SM00443): G-patch domain
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
OrfB_IS605 (PF01385, IPR001959): Probable transposase
RtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
Surp (PF01805, IPR000061, SM00648): Surp module
G-patch_2 (PF12656, IPR026822): G-patch domain
22 TDRD7interactor200TUDOR (PF00567, IPR002999, SM00333): Tudor domain
OST-HTH (PF12872, IPR025605): OST-HTH/LOTUS domain
23 TUBGCP3interactor30.6670.500Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
24 XPO1interactor80.32117.833CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
25 YWHABinteractor60.8001.56714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
26 YWHAGprotein found in more fusions90.6076.63314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
27 YWHAQinteractor70.5716.40014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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