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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LOC400499, AKR1A1 (from a repository: Sun Aug 18 05:27:02 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins8 (26.67 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)96 (22.07 %)
The number (and %) of affected PPIs28 (29.17 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI5.800
Assortativity coefficient-0.3446
The network average Clustering coefficient0.600
The number (and %) of a zero Clustering coefficients5 (16.67 %)
The number (and %) of a zero Betweenness Centrality14 (46.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LOC400499,AKR1A1 All fusions
Proteins found in more fusions TKT (see 5 fusions); TERF2IP (see 1 fusions); ECHS1 (see 1 fusions); GAPDH (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LOC400499interactor000C8 (PF08742, IPR014853, SM00832): C8 domain
DUF1943 (PF09172, IPR015255, SM01169): Domain of unknown function (DUF1943)
VWD (PF00094, IPR001846, SM00216): von Willebrand factor type D domain
Vitellogenin_N (PF01347, IPR001747, SM00638): Lipoprotein amino terminal region
2 AKR1A1parental protein280.156478.586Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
3 ARFIP1interactor21.0000Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
4 C11orf54interactor40.8330.667DUF1907 (PF08925, IPR015021, SM01168): Domain of Unknown Function (DUF1907)
5 CFL1interactor110.54516.619Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
6 DAZAP1interactor100.48915.633RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
7 ECHS1protein found in more fusions41.0000ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
8 EXOSC4interactor200RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
9 GAPDHoncoprotein80.7622.500Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
10 GNPDA2interactor40.6671.500Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
11 GPIinteractor21.0000PGI (PF00342, IPR001672): Phosphoglucose isomerase
12 GRHPRinteractor21.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
13 IGHG2oncoprotein100C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
14 MEMO1interactor100DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
15 NANSinteractor41.0000NeuB (PF03102, IPR013132): NeuB family
SAF (PF08666, IPR013974, SM00858): SAF domain
16 NME1-NME2interactor80.5009.233NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
17 NME2interactor61.0000NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
18 PCBP1oncoprotein100.48918.133Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
19 PDCD6oncoprotein50.6672.000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
20 PGK1interactor41.0000PGK (PF00162, IPR001576): Phosphoglycerate kinase
21 PGK2interactor100PGK (PF00162, IPR001576): Phosphoglycerate kinase
22 PKMoncoprotein90.6396.933PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
23 PTGR1interactor21.0000ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_N_2 (PF16884): N-terminal domain of oxidoreductase
24 SNX12interactor40.5001.619PX (PF00787, IPR001683, SM00312): PX domain
25 SNX3interactor30.6670.286PX (PF00787, IPR001683, SM00312): PX domain
26 SOD1interactor110.53313.486Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
27 TALDO1interactor80.5009.986TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
28 TERF1interactor80.6675.067TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
29 TERF2IPprotein found in more fusions41.0000BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
30 TKTprotein found in more fusions170.37555.752Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain

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