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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins AKR1A1, CBY1 (from a repository: Tue Feb 25 21:43:33 2020)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins9 (23.08 %)
The number (and %) of the tumor suppressors3 (7.69 %)
Total number of binary PPIs (saturation %)111 (14.98 %)
The number (and %) of affected PPIs37 (33.33 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI5.077
Assortativity coefficient-0.1983
The network average Clustering coefficient0.504
The number (and %) of a zero Clustering coefficients10 (25.64 %)
The number (and %) of a zero Betweenness Centrality19 (48.72 %)


List of the fusions

PPI for parental proteins: CBY1,AKR1A1 All fusions
Proteins found in more fusions PDCD6 (see 1 fusions); TKT (see 5 fusions); TERF2IP (see 1 fusions); CDK6 (see 1 fusions); CLU (see 5 fusions); ECHS1 (see 1 fusions); GAPDH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CBY1parental protein90.056444.000Chibby (PF14645, IPR028118): Chibby family
2 AKR1A1parental protein280.156815.252Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
3 AGTPBP1interactor100Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
4 ARFIP1interactor21.0000Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
5 C11orf54interactor40.8330.667DUF1907 (PF08925, IPR015021, SM01168): Domain of Unknown Function (DUF1907)
6 CDK6suppressor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
7 CFAP53interactor100Rsc14 (PF08586, IPR013895): RSC complex, Rsc14/Ldb7 subunit
YtxH (PF12732, IPR024623): YtxH-like protein
TPH (PF13868): Trichohyalin-plectin-homology domain
8 CFL1interactor110.54516.619Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
9 CLUsuppressor200Clusterin (PF01093, IPR000753): Clusterin
10 CTNNB1oncoprotein30.66730.000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
11 DAZAP1interactor100.48915.633RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
12 ECHS1protein found in more fusions41.0000ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
13 EXOSC4interactor200RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
14 FAM92A1interactor100FAM92 (PF06730, IPR009602): FAM92 protein
15 GAPDHoncoprotein80.76219.167Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
16 GNPDA2interactor40.6671.500Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
17 GPIinteractor21.0000PGI (PF00342, IPR001672): Phosphoglucose isomerase
18 GRHPRinteractor21.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
19 IGHG2oncoprotein100C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
20 MEMO1interactor100DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
21 NANSinteractor41.0000NeuB (PF03102, IPR013132): NeuB family
SAF (PF08666, IPR013974, SM00858): SAF domain
22 NBPF11interactor100DUF1220 (PF06758, IPR010630, SM01148): Repeat of unknown function (DUF1220)
DUF1258 (PF06869, IPR009667): Protein of unknown function (DUF1258)
GAT (PF03127, IPR004152): GAT domain
MAP (PF03642, IPR005298): MAP domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
23 NME1-NME2interactor80.5009.233NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
24 NME2interactor61.0000NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
25 PCBP1oncoprotein100.48918.133Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
26 PDCD6oncoprotein50.6672.000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
27 PGK1interactor50.600560.000PGK (PF00162, IPR001576): Phosphoglycerate kinase
28 PGK2interactor100PGK (PF00162, IPR001576): Phosphoglycerate kinase
29 PKMoncoprotein90.63936.933PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
30 PTGR1interactor21.0000ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_N_2 (PF16884): N-terminal domain of oxidoreductase
31 SFNsuppressor40.333522.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
32 SNX12interactor40.5001.619PX (PF00787, IPR001683, SM00312): PX domain
33 SNX3interactor30.6670.286PX (PF00787, IPR001683, SM00312): PX domain
34 SOD1interactor110.53313.486Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
35 TALDO1interactor80.5009.986TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
36 TERF1interactor80.6675.067TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
37 TERF2IPprotein found in more fusions41.0000BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
38 TKTprotein found in more fusions170.375152.419Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
39 TTC23Linteractor100COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
DUF4398 (PF14346, IPR025511): Domain of unknown function (DUF4398)

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