Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins AKR1A1, CBY1 (from a repository: Mon Oct 14 17:14:57 2019)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins9 (23.08 %)
The number (and %) of the tumor suppressors3 (7.69 %)
Total number of binary PPIs (saturation %)111 (14.98 %)
The number (and %) of affected PPIs37 (33.33 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI5.077
Assortativity coefficient-0.1983
The network average Clustering coefficient0.504
The number (and %) of a zero Clustering coefficients10 (25.64 %)
The number (and %) of a zero Betweenness Centrality19 (48.72 %)


List of the fusions

PPI for parental proteins: CBY1,AKR1A1 All fusions
Proteins found in more fusions PDCD6 (see 1 fusions); TKT (see 5 fusions); TERF2IP (see 1 fusions); CDK6 (see 1 fusions); CLU (see 5 fusions); ECHS1 (see 1 fusions); GAPDH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CBY1parental protein90.056444.000Chibby (PF14645, IPR028118): Chibby family
2 AKR1A1parental protein280.156815.252Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
3 AGTPBP1interactor100Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
4 ARFIP1interactor21.0000Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
5 C11orf54interactor40.8330.667DUF1907 (PF08925, IPR015021, SM01168): Domain of Unknown Function (DUF1907)
6 CDK6suppressor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
7 CFAP53interactor100Rsc14 (PF08586, IPR013895): RSC complex, Rsc14/Ldb7 subunit
YtxH (PF12732, IPR024623): YtxH-like protein
TPH (PF13868): Trichohyalin-plectin-homology domain
8 CFL1interactor110.54516.619Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
9 CLUsuppressor200Clusterin (PF01093, IPR000753): Clusterin
10 CTNNB1oncoprotein30.66730.000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
11 DAZAP1interactor100.48915.633RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
12 ECHS1protein found in more fusions41.0000ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
13 EXOSC4interactor200RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
14 FAM92A1interactor100FAM92 (PF06730, IPR009602): FAM92 protein
15 GAPDHoncoprotein80.76219.167Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
16 GNPDA2interactor40.6671.500Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
17 GPIinteractor21.0000PGI (PF00342, IPR001672): Phosphoglucose isomerase
18 GRHPRinteractor21.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
19 IGHG2oncoprotein100C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
20 MEMO1interactor100DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
21 NANSinteractor41.0000NeuB (PF03102, IPR013132): NeuB family
SAF (PF08666, IPR013974, SM00858): SAF domain
22 NBPF11interactor100DUF1220 (PF06758, IPR010630, SM01148): Repeat of unknown function (DUF1220)
DUF1258 (PF06869, IPR009667): Protein of unknown function (DUF1258)
GAT (PF03127, IPR004152): GAT domain
MAP (PF03642, IPR005298): MAP domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
23 NME1-NME2interactor80.5009.233NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
24 NME2interactor61.0000NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
25 PCBP1oncoprotein100.48918.133Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
26 PDCD6oncoprotein50.6672.000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
27 PGK1interactor50.600560.000PGK (PF00162, IPR001576): Phosphoglycerate kinase
28 PGK2interactor100PGK (PF00162, IPR001576): Phosphoglycerate kinase
29 PKMoncoprotein90.63936.933PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
30 PTGR1interactor21.0000ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_N_2 (PF16884): N-terminal domain of oxidoreductase
31 SFNsuppressor40.333522.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
32 SNX12interactor40.5001.619PX (PF00787, IPR001683, SM00312): PX domain
33 SNX3interactor30.6670.286PX (PF00787, IPR001683, SM00312): PX domain
34 SOD1interactor110.53313.486Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
35 TALDO1interactor80.5009.986TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
36 TERF1interactor80.6675.067TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
37 TERF2IPprotein found in more fusions41.0000BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
38 TKTprotein found in more fusions170.375152.419Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
39 TTC23Linteractor100COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
DUF4398 (PF14346, IPR025511): Domain of unknown function (DUF4398)

B a c k    t o    T o p ⇑