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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)119
The number (and %) of the onco-proteins37 (31.09 %)
The number (and %) of the tumor suppressors18 (15.13 %)
Total number of binary PPIs (saturation %)631 (8.99 %)
The number (and %) of affected PPIs117 (18.54 %)
The number of possible different fusions13
PPI diameter2
PPI radiusinf
The average degree of PPI9.782
Assortativity coefficient-0.3314
The network average Clustering coefficient0.556
The number (and %) of a zero Clustering coefficients17 (14.29 %)
The number (and %) of a zero Betweenness Centrality42 (35.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FZR1,NMUR1 All fusions
Proteins found in more fusions EMILIN1 (see 2 fusions); STAU1 (see 2 fusions); UBE2C (see 1 fusions); TRIM33 (see 1 fusions); CUL1 (see 3 fusions); RBBP8 (see 1 fusions); USP1 (see 1 fusions); VHL (see 1 fusions); PRKDC (see 3 fusions); NEDD9 (see 1 fusions); DDB1 (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FZR1parental protein1160.0709454.595WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
2 NMUR1parental protein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
7tm_4 (PF13853): Olfactory receptor
3 ANAPC1suppressor220.64133.138PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
ANAPC1 (PF12859, IPR024990): Anaphase-promoting complex subunit 1
4 ANAPC10interactor150.8194.373ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
5 ANAPC11interactor190.44452.715zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
6 ANAPC15interactor160.7759.024Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
ANAPC15 (PF15243, IPR026182): Anaphase-promoting complex subunit 15
7 ANAPC2interactor280.402139.001ANAPC2 (PF08672, IPR014786, SM01013): Anaphase promoting complex (APC) subunit 2
Cullin (PF00888, IPR001373, SM00182): Cullin family
8 ANAPC4interactor300.47875.257ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
ANAPC4 (PF12896, IPR024790): Anaphase-promoting complex, cyclosome, subunit 4
9 ANAPC5interactor210.60524.565TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
10 ANAPC7interactor240.60129.537TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_21 (PF09976, IPR018704): Tetratricopeptide repeat-like domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
11 ARHGAP32oncoprotein21.0000PX (PF00787, IPR001683, SM00312): PX domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SH3_9 (PF14604, IPR001452): Variant SH3 domain
12 AURKBinteractor130.36425.005Pkinase (PF00069, IPR000719): Protein kinase domain
13 BEX1interactor21.0000BEX (PF04538, IPR021156): Brain expressed X-linked like family
14 BLIDsuppressor100NA
15 BRSK2interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
16 BTRConcoprotein200.29876.379WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
17 BUB1Boncoprotein200.47438.891Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Mad3_BUB1_II (PF08171, IPR012572): Mad3/BUB1 homology region 2
Pkinase (PF00069, IPR000719): Protein kinase domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
18 CCL5interactor100IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
19 CCNA1interactor140.60414.036Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
20 CCNA2oncoprotein230.41659.455Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
21 CCNB1oncoprotein250.290131.504Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
22 CDC14Ainteractor50.6001.622DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Pentaxin (PF00354, IPR001759, SM00159): Pentaxin family
PTPlike_phytase (PF14566): Inositol hexakisphosphate
DSPn (PF14671, IPR029260): Dual specificity protein phosphatase, N-terminal half
23 CDC14Binteractor30.6670.182DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
DSPn (PF14671, IPR029260): Dual specificity protein phosphatase, N-terminal half
24 CDC16interactor250.56339.412Dynein_light (PF01221, IPR001372): Dynein light chain type 1
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
SRP_TPR_like (PF17004, IPR031545): Putative TPR-like repeat
25 CDC20oncoprotein570.197867.080WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
26 CDC23interactor260.56743.852ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23
DUF772 (PF05598, IPR008490): Transposase domain (DUF772)
Menin (PF05053, IPR007747): Menin
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
27 CDC25Aoncoprotein70.5713.552M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
28 CDC26interactor140.8682.643ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
29 CDC27oncoprotein400.302270.175TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
30 CDC6oncoprotein90.6676.143Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
AAA_22 (PF13401, IPR003593): AAA domain
ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
31 CDCA3interactor21.0000NA
32 CDK1oncoprotein220.40065.140Pkinase (PF00069, IPR000719): Protein kinase domain
33 CDK2suppressor220.43357.942Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
34 CDK5oncoprotein70.6671.565Pkinase (PF00069, IPR000719): Protein kinase domain
35 CDR2interactor31.0000DivIC (PF04977, IPR007060): Septum formation initiator
SlyX (PF04102, IPR007236): SlyX
Striatin (PF08232, IPR013258): Striatin family
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
36 CDT1oncoprotein160.49227.190CDT1 (PF08839, IPR014939, SM01075): DNA replication factor CDT1 like
CDT1_C (PF16679, IPR032054): DNA replication factor Cdt1 C-terminal domain
37 CKAP2interactor30.6670.500Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
CKAP2_C (PF15297, IPR029197): Cytoskeleton-associated protein 2 C-terminus
38 CKS1Boncoprotein110.7782.120CKS (PF01111, IPR000789, SM01084): Cyclin-dependent kinase regulatory subunit
39 CLSPNinteractor40.8330.286Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein
Presenilin (PF01080, IPR001108): Presenilin
PTS_IIB (PF02302, IPR003501): PTS system, Lactose/Cellobiose specific IIB subunit
XAP5 (PF04921, IPR007005): XAP5, circadian clock regulator
Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
40 CSF3Roncoprotein100EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain
41 CUEDC2interactor31.0000CUE (PF02845, IPR003892, SM00546): CUE domain
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
42 CUL1suppressor200.29881.141Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
43 CYP17A1interactor100p450 (PF00067, IPR001128): Cytochrome P450
44 DAXXoncoprotein70.4007.419Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Nop14 (PF04147, IPR007276): Nop14-like family
RF-1 (PF00472, IPR000352): RF-1 domain
Vpu (PF00558, IPR008187): Vpu protein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
45 DCPSinteractor41.0000DcpS (PF05652, IPR008594): Scavenger mRNA decapping enzyme (DcpS) N-terminal
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
46 DDB1protein found in more fusions110.48913.033CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
47 DKK3suppressor100Dickkopf_N (PF04706, IPR006796): Dickkopf N-terminal cysteine-rich region
HSCB_C (PF07743, IPR009073): HSCB C-terminal oligomerisation domain
Nodulin_late (PF07127, IPR009810): Late nodulin protein
VCX_VCY (PF15231, IPR026653): Variable charge X/Y family
48 DNM1Linteractor50.5002.333Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
AAA_16 (PF13191): AAA ATPase domain
49 E2F1suppressor160.49224.434Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
50 E2F3suppressor31.0000E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
51 EMILIN1protein found in more fusions41.0000C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
EMI (PF07546, IPR011489): EMI domain
IncA (PF04156, IPR007285): IncA protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Unstab_antitox (PF09720, IPR013406): Putative addiction module component
DUF2802 (PF10975, IPR021244): Protein of unknown function (DUF2802)
DUF3720 (PF12517, IPR022195): Protein of unknown function (DUF3720)
MscS_porin (PF12795, IPR024393): Mechanosensitive ion channel porin domain
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
52 EPHA4interactor30.6671.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
SusE (PF14292, IPR025970): SusE outer membrane protein
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
53 EPSTI1interactor21.0000TAF8_C (PF10406, IPR019473): Transcription factor TFIID complex subunit 8 C-term
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666)
54 EYA1interactor21.0000NA
55 FANCD2oncoprotein40.5002.167FancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease
56 FBXO5oncoprotein160.67514.336IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
F-box (PF00646, IPR001810, SM00256): F-box domain
57 FMR1interactor31.0000Agenet (PF05641, IPR008395, SM00743): Agenet domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXMR_C2 (PF16098, IPR032196): Fragile X-related mental retardation protein C-terminal region 2
58 FOXM1oncoprotein60.8670.400EspF (PF04806, IPR006891): EspF protein repeat
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
59 GMNNinteractor61.0000Geminin (PF07412, IPR022786): Geminin
60 GRIA1interactor21.0000ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
61 HCCSinteractor100Cyto_heme_lyase (PF01265, IPR000511): Cytochrome c/c1 heme lyase
62 HECW2interactor130.56113.630C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
63 HSF2interactor31.0000HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
64 ID1interactor30.6670.400HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
65 IST1interactor31.0000Ist1 (PF03398, IPR005061): Regulator of Vps4 activity in the MVB pathway
66 KIAA0101interactor100PAF (PF15715, IPR031444): PCNA-associated factor
67 KMT5Ainteractor31.0000ATP-synt_Eps (PF04627, IPR006721): Mitochondrial ATP synthase epsilon chain
ERp29 (PF07749, IPR011679): Endoplasmic reticulum protein ERp29, C-terminal domain
SET (PF00856, IPR001214, SM00317): SET domain
68 LRRC46interactor100LRR_9 (PF14580): Leucine-rich repeat
69 MAD2L2interactor41.0000HORMA (PF02301, IPR003511): HORMA domain
70 MAKinteractor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
71 MAPK8oncoprotein50.8330.286DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
72 MDC1suppressor150.59027.968FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
73 MOAP1interactor200PNMA (PF14893, IPR026523): PNMA
74 MTA3oncoprotein21.0000BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
75 NAT2oncoprotein100Acetyltransf_2 (PF00797, IPR001447): N-acetyltransferase
76 NEDD9protein found in more fusions200Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain
DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
77 NEK2interactor100.8063.182Pkinase (PF00069, IPR000719): Protein kinase domain
78 NINLinteractor80.5367.520PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
TBCA (PF02970, IPR004226): Tubulin binding cofactor A
DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
79 NMUinteractor100NMU (PF02070, IPR008200, SM00084): Neuromedin U
80 PARK2suppressor130.30329.640IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
81 PAX3oncoprotein21.0000PAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Pax7 (PF12360, IPR022106): Paired box protein 7
82 PHF8interactor120.8791.809JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
PHD (PF00628, IPR019787, SM00249): PHD-finger
TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
83 PIM1oncoprotein50.6670.619Pkinase (PF00069, IPR000719): Protein kinase domain
84 PLK1suppressor120.30328.583Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
85 PRKDCprotein found in more fusions100.38912.249FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
86 PSMC3IPinteractor100Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
87 PTENsuppressor90.41715.534DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
88 PTTG1oncoprotein110.5337.891Securin (PF04856, IPR006940): Securin sister-chromatid separation inhibitor
89 RACGAP1interactor40.5000.915RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
90 RB1suppressor190.33973.324RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
91 RBBP8suppressor60.4004.286ZapB (PF06005, IPR009252): Cell division protein ZapB
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
92 RNF34interactor40.6670.419Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
93 RRM2interactor80.3939.891Ribonuc_red_sm (PF00268, IPR000358): Ribonucleotide reductase, small chain
94 SENP2interactor21.0000Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
95 SIRT2suppressor31.0000SIR2 (PF02146, IPR003000): Sir2 family
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
96 SIX1oncoprotein21.0000KilA-N (PF04383, IPR018004): KilA-N domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
SIX1_SD (PF16878, IPR031701): Transcriptional regulator, SIX1, N-terminal SD domain
97 SKILsuppressor40.6670.400c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
98 SKP2suppressor190.43952.042LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_2 (PF07723, IPR013101): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
99 SMURF1interactor70.5335.567C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
100 SOX2oncoprotein130.56121.763HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
101 SPRTNinteractor21.0000GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term
SprT-like (PF10263, IPR006640, SM00731): SprT-like family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
102 STAU1protein found in more fusions100.30619.588dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
103 TACC3oncoprotein100TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
104 TAS2R13interactor21.0000TAS2R (PF05296, IPR007960): Taste receptor protein (TAS2R)
105 THRSPoncoprotein200Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
106 TK1oncoprotein40.6670.133TK (PF00265, IPR001267, SM00203): Thymidine kinase
107 TP53suppressor300.135266.406DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
108 TPX2interactor30.6670.500Aurora-A_bind (PF09041, IPR015128): Aurora-A binding
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
DUF2259 (PF10016, IPR018725): Predicted secreted protein (DUF2259)
TPX2_importin (PF12214, IPR027330): Cell cycle regulated microtubule associated protein
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
109 TRIM33oncoprotein150.62621.488PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Siva (PF05458, IPR022773): Cd27 binding protein (Siva)
Spectrin (PF00435, IPR002017): Spectrin repeat
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
110 TTKinteractor90.6433.215Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Pkinase (PF00069, IPR000719): Protein kinase domain
RIO1 (PF01163, IPR018934): RIO1 family
T3SS_basalb_I (PF17001, IPR012670): Type III secretion basal body protein I, YscI, HrpB, PscI
Mad3_BUB1_I_2 (PF17014, IPR031522): Putative Mad3/BUB1 like region 1 protein
111 UBE2Concoprotein80.5247.301UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
112 UBE2D1interactor70.4005.352UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
113 UBE2D3interactor90.28612.622UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
114 UBE2Kinteractor50.6001.456UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
115 UBE2Sinteractor140.82110.915ALF (PF03752, IPR005506): Short repeats of unknown function
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
116 USP1protein found in more fusions50.5001.833UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
117 USP37interactor180.55924.934UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UCH_N (PF16674, IPR032069): N-terminal of ubiquitin carboxyl-terminal hydrolase 37
118 VHLsuppressor90.39312.998Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
119 ZC3HC1interactor30.6670.200Rsm1 (PF08600, IPR013909): Rsm1-like
zf-C3HC (PF07967, IPR012935): C3HC zinc finger-like

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