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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)147
The number (and %) of the onco-proteins50 (34.01 %)
The number (and %) of the tumor suppressors26 (17.69 %)
Total number of binary PPIs (saturation %)1100 (10.25 %)
The number (and %) of affected PPIs145 (13.18 %)
The number of possible different fusions33
PPI diameter2
PPI radiusinf
The average degree of PPI14.068
Assortativity coefficient-0.2823
The network average Clustering coefficient0.529
The number (and %) of a zero Clustering coefficients8 (5.44 %)
The number (and %) of a zero Betweenness Centrality25 (17.01 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions NPM1 (see 1 fusions); ACTG1/ACTB (see 1 fusions); COMMD1 (see 1 fusions); CDK6 (see 1 fusions); CTBP2 (see 2 fusions); VHL (see 1 fusions); MYC (see 1 fusions); MDM4 (see 2 fusions); PIAS2 (see 2 fusions); PSME3 (see 2 fusions); ACTB (see 3 fusions); BCL2L1 (see 1 fusions); ACTG1 (see 4 fusions); COPS5 (see 1 fusions); IKBKB (see 2 fusions); PCNA (see 1 fusions); CCND1 (see 1 fusions); TP53 (see 3 fusions); HSP90AA1 (see 2 fusions); TRIM28 (see 1 fusions); ATR (see 1 fusions); HUWE1 (see 2 fusions); HSP90AB1 (see 1 fusions); PDCD6 (see 1 fusions); YY1 (see 2 fusions); SP1 (see 1 fusions); MCM2 (see 1 fusions); KAT5 (see 3 fusions); HNRNPC (see 1 fusions); PML (see 4 fusions); NCL (see 3 fusions); GAPDH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CDKN2Aparental protein1450.08512330.806Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
2 FAM230Ainteractor000NA
3 ACLYinteractor70.7141.409ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Citrate_synt (PF00285, IPR002020): Citrate synthase, C-terminal domain
CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
Citrate_bind (PF16114, IPR032263): ATP citrate lyase citrate-binding
4 ACTA1interactor120.39422.593Actin (PF00022, IPR004000, SM00268): Actin
5 ACTBoncoprotein210.40044.197Actin (PF00022, IPR004000, SM00268): Actin
6 ACTBL2interactor100.42210.869Actin (PF00022, IPR004000, SM00268): Actin
7 ACTG1protein found in more fusions220.33371.739Actin (PF00022, IPR004000, SM00268): Actin
8 ACTN4interactor70.6192.614CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
9 ANGPTL4suppressor60.6671.050SlyX (PF04102, IPR007236): SlyX
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
10 ARFIP2interactor31.0000Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
11 ATRsuppressor150.37430.146FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
THP2 (PF09432, IPR018557): Tho complex subunit THP2
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
SgrT (PF15894, IPR031767): Inhibitor of glucose uptake transporter SgrT
12 AURKAoncoprotein300.318137.129Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
13 BAG6interactor70.3337.456DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
14 BCL2L1oncoprotein70.6004.300Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
15 BECN1suppressor60.5002.382APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
16 BRCA1suppressor360.261227.036BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
17 BRK1interactor50.9000.500DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
18 C1QBPinteractor130.43612.341MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
19 CASC3oncoprotein30.6670.400Btz (PF09405, IPR018545, SM01044): CASC3/Barentsz eIF4AIII binding
UPF0560 (PF10577, IPR018890): Uncharacterised protein family UPF0560
PRIMA1 (PF16101): Proline-rich membrane anchor 1
20 CCND1oncoprotein190.39947.137Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
21 CCND2oncoprotein40.8330.667Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
22 CCNG1oncoprotein50.6000.561Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
23 CDC45interactor40.6670.900CDC45 (PF02724, IPR003874): CDC45-like protein
24 CDC5Linteractor290.280122.744OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
25 CDC6oncoprotein90.5565.931Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
AAA_22 (PF13401, IPR003593): AAA domain
ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
26 CDC7interactor70.7331.419Pkinase (PF00069, IPR000719): Protein kinase domain
27 CDK11Aoncoprotein21.0000DDHD (PF02862, IPR004177, SM01127): DDHD domain
eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
Pkinase (PF00069, IPR000719): Protein kinase domain
RIO1 (PF01163, IPR018934): RIO1 family
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
DHHW (PF14286, IPR025945): DHHW protein
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
28 CDK4oncoprotein220.29499.727Pkinase (PF00069, IPR000719): Protein kinase domain
29 CDK5RAP3interactor60.8000.376DUF773 (PF05600, IPR008491): Protein of unknown function (DUF773)
30 CDK6suppressor140.39728.026Pkinase (PF00069, IPR000719): Protein kinase domain
31 CDKN2AIPinteractor50.6000.587XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
32 CFAP97interactor100DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
KIAA1430 (PF13879, IPR029488): KIAA1430 homologue
GH97_C (PF14509, IPR029483): Glycosyl-hydrolase 97 C-terminal, oligomerisation
33 CLK2interactor80.6672.223DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-met (PF12874): Zinc-finger of C2H2 type
34 COMMD1protein found in more fusions70.8000.479COMMD1_N (PF17221): COMMD1 N-terminal domain
COMM_domain (PF07258): COMM domain
35 COPS5protein found in more fusions380.315161.316JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
36 CRELD2interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
VSP (PF03302, IPR005127): Giardia variant-specific surface protein
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
DUF3456 (PF11938, IPR021852): TLR4 regulator and MIR-interacting MSAP
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
37 CSTF2interactor60.4007.067RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
CSTF_C (PF14304, IPR026896): Transcription termination and cleavage factor C-terminal
CSTF2_hinge (PF14327, IPR025742): Hinge domain of cleavage stimulation factor subunit 2
38 CTBP2protein found in more fusions60.5002.9172-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
39 CUL2suppressor310.269123.088Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
40 DAXXoncoprotein110.6227.487Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Nop14 (PF04147, IPR007276): Nop14-like family
RF-1 (PF00472, IPR000352): RF-1 domain
Vpu (PF00558, IPR008187): Vpu protein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
41 DEAF1interactor21.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAND (PF01342, IPR000770, SM00258): SAND domain
zf-MYND (PF01753, IPR002893): MYND finger
42 DGCR8interactor40.5000.446dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
WW (PF00397, IPR001202, SM00456): WW domain
43 DYRK1Boncoprotein40.6670.500Pkinase (PF00069, IPR000719): Protein kinase domain
44 E2F1suppressor120.42412.088Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
45 E4F1interactor41.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type
46 EEF2interactor170.59617.228EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
47 EGR1suppressor50.9000.133zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF3432 (PF11914, IPR021839): Domain of unknown function (DUF3432)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
48 EPHA3suppressor21.0000EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
49 FKBP2interactor21.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
50 FN1oncoprotein360.268188.217fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
51 GAPDHoncoprotein210.59517.470Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
52 GGA1oncoprotein31.0000Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
GAT (PF03127, IPR004152): GAT domain
Hormone_3 (PF00159, IPR001955): Pancreatic hormone peptide
VHS (PF00790, IPR002014, SM00288): VHS domain
AP3B1_C (PF14796, IPR029390): Clathrin-adaptor complex-3 beta-1 subunit C-terminal
53 GGA3interactor40.5002.133Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
54 GMNNinteractor40.5001.889Geminin (PF07412, IPR022786): Geminin
55 GNL3interactor90.7225.269GN3L_Grn1 (PF08701, IPR014813): GNL3L/Grn1 putative GTPase
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
FAM176 (PF14851): FAM176 family
56 HDAC1suppressor330.347146.082FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
57 HIF1Asuppressor240.48243.782Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
58 HIPK4interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
59 HIST3H2BBinteractor60.6001.488Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
60 HNRNPA2B1oncoprotein180.39921.374RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
61 HNRNPCprotein found in more fusions170.45814.373APG6 (PF04111, IPR007243): Autophagy protein Apg6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
62 HNRNPUinteractor300.347123.859CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
63 HSP90AA1oncoprotein460.284392.298HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
64 HSP90AB1oncoprotein290.43467.550HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
65 HSPA4interactor240.40659.430Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
66 HSPA8oncoprotein310.372122.459HSP70 (PF00012, IPR013126): Hsp70 protein
67 HSPA9oncoprotein190.48032.620HSP70 (PF00012, IPR013126): Hsp70 protein
68 HUWE1oncoprotein360.244232.048BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
69 IKBKBprotein found in more fusions110.5566.558FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
70 ING1suppressor60.8670.556PHD (PF00628, IPR019787, SM00249): PHD-finger
NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
71 ING4suppressor60.7001.833PHD (PF00628, IPR019787, SM00249): PHD-finger
SOGA (PF11365, IPR027881): Protein SOGA
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
72 IQGAP1interactor170.38233.758CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
73 KAT5suppressor220.41954.432MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
74 LAMTOR3interactor21.0000MAPKK1_Int (PF08923, IPR015019): Mitogen-activated protein kinase kinase 1 interacting
75 LSM8interactor40.5002.067LSM (PF01423, IPR001163): LSM domain
76 MAPK10suppressor51.0000Pkinase (PF00069, IPR000719): Protein kinase domain
77 MAPK8oncoprotein90.6074.725DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
78 MCM10interactor100.51112.184Mcm10 (PF09332, IPR015411): Mcm10 replication factor
zf-primase (PF09329, IPR015408): Primase zinc finger
AATF-Che1 (PF13339, IPR025160): Apoptosis antagonizing transcription factor
79 MCM2oncoprotein410.235314.884AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
80 MCM5oncoprotein230.37563.653MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
81 MCM6interactor140.42329.166MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
82 MDM2oncoprotein520.223504.458Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
83 MDM4oncoprotein90.5364.556zf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
84 MIS12interactor21.0000DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
Mis12 (PF05859, IPR008685): Mis12 protein
85 MMRN1interactor100C1q (PF00386, IPR001073, SM00110): C1q domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EMI (PF07546, IPR011489): EMI domain
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RPW8 (PF05659, IPR008808): Arabidopsis broad-spectrum mildew resistance protein RPW8
SlyX (PF04102, IPR007236): SlyX
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
86 MOV10interactor210.224104.991AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
87 MTRinteractor30.6670.133B12-binding (PF02310, IPR006158): B12 binding domain
B12-binding_2 (PF02607, IPR003759, SM01018): B12 binding domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
Met_synt_B12 (PF02965, IPR004223): Vitamin B12 dependent methionine synthase, activation domain
Pterin_bind (PF00809, IPR000489): Pterin binding enzyme
S-methyl_trans (PF02574, IPR003726): Homocysteine S-methyltransferase
DUF2760 (PF10816, IPR021212): Domain of unknown function (DUF2760)
88 MYConcoprotein420.256304.198HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
89 MYCNoncoprotein60.5332.800HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
90 MYL12Ainteractor50.6000.663EF-hand_11 (PF08976, IPR015070): EF-hand domain
DUF2267 (PF10025, IPR018727): Uncharacterized conserved protein (DUF2267)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
91 MYO1Cinteractor90.5006.754IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
92 NAT2oncoprotein21.0000Acetyltransf_2 (PF00797, IPR001447): N-acetyltransferase
93 NCKAP1interactor50.7001.917Nckap1 (PF09735, IPR019137): Membrane-associated apoptosis protein
94 NCLprotein found in more fusions250.38865.120DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
95 NMIinteractor90.5716.015IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
96 NPM1suppressor390.334179.435Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
97 NXF1interactor260.213121.226NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
98 ORC4interactor60.8000.951AAA_16 (PF13191): AAA ATPase domain
ORC4_C (PF14629, IPR032705): Origin recognition complex (ORC) subunit 4 C-terminus
99 PA2G4interactor140.46213.933Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
TraC (PF07820, IPR012930): TraC-like protein
100 PCNAoncoprotein220.30577.934PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
101 PDCD6oncoprotein120.5644.785EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
102 PIAS2protein found in more fusions80.7621.719SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
103 PMLsuppressor220.41959.187zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
104 PPP1CBinteractor170.33138.450Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
105 PPP1CConcoprotein210.35262.282Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
106 PPP1R9Binteractor70.5712.678PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Stm1_N (PF09598, IPR019084): Stm1
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
NuDC (PF16273, IPR032572): Nuclear distribution C domain
107 PRKCAinteractor80.5712.862C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
108 PSMC3interactor130.4857.318AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
109 PSME3protein found in more fusions120.5279.444PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
110 RELAoncoprotein250.37776.607DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
111 RIN2interactor200RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
112 RNF2interactor290.259128.805zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
113 RPL11suppressor170.59612.473Ribosomal_L5 (PF00281, IPR002132): Ribosomal protein L5
Ribosomal_L5_C (PF00673, IPR002132): ribosomal L5P family C-terminus
114 RPP38interactor40.6671.000Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
115 RUVBL2oncoprotein190.47719.760TIP49 (PF06068, IPR010339): TIP49 C-terminus
116 SAP25interactor30.6670.333SAP25 (PF15476, IPR029163): Histone deacetylase complex subunit SAP25
117 SENP3interactor180.45128.880Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis)
Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
118 SERTAD1interactor40.6671.400CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
SERTA (PF06031, IPR009263): SERTA motif
119 SIVA1interactor41.0000Siva (PF05458, IPR022773): Cd27 binding protein (Siva)
120 SLC4A1oncoprotein200Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain
HCO3_cotransp (PF00955, IPR011531): HCO3- transporter family
121 SMARCA4suppressor200.42154.717DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065)
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
122 SNRPAinteractor90.5363.342RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
123 SNRPBinteractor60.4003.516LSM (PF01423, IPR001163): LSM domain
124 SP1protein found in more fusions280.333105.578zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
125 TDRD7interactor200TUDOR (PF00567, IPR002999, SM00333): Tudor domain
OST-HTH (PF12872, IPR025605): OST-HTH/LOTUS domain
126 TOP1oncoprotein150.51412.274DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
TonB_N (PF16031): TonB N-terminal region
127 TP53suppressor720.1871146.007DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
128 TP63suppressor160.40034.512Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
129 TRADDinteractor31.0000Death (PF00531, IPR000488, SM00005): Death domain
TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain
TPR_14 (PF13428): Tetratricopeptide repeat
130 TRIM28protein found in more fusions240.39958.869ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
131 TRIP12interactor70.3819.967Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
WWE (PF02825, IPR004170, SM00678): WWE domain
SOG2 (PF10428, IPR019487): RAM signalling pathway protein
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
HEAT_2 (PF13646): HEAT repeats
132 TTF1suppressor21.0000DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Spore_II_R (PF09551, IPR014202): Stage II sporulation protein R (spore_II_R)
Yae1_N (PF09811, IPR019191): Essential protein Yae1, N terminal
Myb_DNA-bind_4 (PF13837): Myb/SANT-like DNA-binding domain
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
DUF4519 (PF15012, IPR027960): Domain of unknown function (DUF4519)
133 TUBA1Aoncoprotein120.6974.485Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
134 TUBA1Cinteractor150.6577.754Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
135 TUBBinteractor230.55322.637Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
136 TUBB4Binteractor160.5589.886Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
137 UBE2Ainteractor51.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
138 UBE2Iinteractor290.291135.913UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
139 UBE4Bsuppressor60.7002.067DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core
U-box (PF04564, IPR003613, SM00504): U-box domain
DUF4568 (PF15132, IPR027919): Domain of unknown function (DUF4568)
140 UCHL1suppressor100.6444.985Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
141 USP26interactor100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UCH_N (PF16674, IPR032069): N-terminal of ubiquitin carboxyl-terminal hydrolase 37
142 VHLsuppressor280.39079.164Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
143 WHSC1L1suppressor40.6670.515PHD (PF00628, IPR019787, SM00249): PHD-finger
Presenilin (PF01080, IPR001108): Presenilin
PWWP (PF00855, IPR000313, SM00293): PWWP domain
SET (PF00856, IPR001214, SM00317): SET domain
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
144 WRNoncoprotein70.6002.095DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
HRDC (PF00570, IPR002121, SM00341): HRDC domain
Laminin_II (PF06009, IPR010307): Laminin Domain II
RQC (PF09382, IPR018982, SM00956): RQC domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
HTH_40 (PF14493, IPR029491): Helix-turn-helix domain
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
145 YY1protein found in more fusions120.7093.020zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
146 ZBTB17interactor70.8001.467BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
147 ZNF420interactor51.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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